You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 29, 2024

Claims for Patent: 8,110,553


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 8,110,553
Title:Methods and compositions for the treatment of gastrointestinal disorders
Abstract: The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
Inventor(s): Currie; Mark G. (Sterling, MA), Mahajan-Miklos; Shalina (Stanford, CA), Milne; G. Todd (Brookline, MA), Norman; Thea (Cambridge, MA)
Assignee: Ironwood Pharmaceuticals, Inc. (Cambridge, MA)
Application Number:12/788,979
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 8,110,553
Patent Claims: 1. A method for increasing intestinal motility in a patient, the method comprising administering to the patient an effective amount of a peptide comprising the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys (SEQ ID NO:125) or a pharmaceutically acceptable salt thereof.

2. The method of claim 1, wherein the peptide consists of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys (SEQ ID NO:125) or a pharmaceutically acceptable salt thereof.

3. A method for treating a patient for a gastrointestinal disorder, the method comprising administering to the patient an effective amount of a peptide comprising the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys (SEQ ID NO:125) or a pharmaceutically acceptable salt thereof.

4. The method of claim 3, wherein the peptide consists of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys (SEQ ID NO:125) or a pharmaceutically acceptable salt thereof.

5. The method of claim 3, wherein the gastrointestinal disorder is selected from the group consisting of: irritable bowel syndrome, constipation, a gastrointestinal motility disorder, gastroesophageal reflux disease, functional heartburn, dyspepsia, gastroparesis, chronic intestinal pseudo-obstruction and colonic pseudo-obstruction.

6. The method of claim 5, wherein the gastrointestinal disorder is constipation.

7. The method of claim 6, wherein the constipation is chronic constipation, idiopathic constipation, constipation due to post-operative ileus, or constipation caused by opiate use.

8. The method of claim 7, wherein the constipation is chronic constipation.

9. The method of claim 5, wherein the gastrointestinal disorder is irritable bowel syndrome.

10. The method of claim 9, wherein the irritable bowel syndrome is constipation-predominant irritable bowel syndrome.

11. The method of claim 9, wherein the irritable bowel syndrome is alternating irritable bowel syndrome.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.