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Claims for Patent: 8,088,934

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Claims for Patent: 8,088,934

Title:Composition and method for stabilizing the same
Abstract: Disclosed is a novel composition comprising a novel bi-cyclic compound, which is expected to be pharmaceutically active, and a glyceride. The stability of the bi-cyclic compound can be improved significantly by dissolving the same in a glyceride.
Inventor(s): Ueno; Ryuji (Montgomery, MD), Habe; Tsuyoshi (Sasayama, JP)
Assignee: SUCAMPO AG (Zurich, CH)
Application Number:12/144,000
Patent Claims: 1. A bi-cyclic compound represented by the formula: ##STR00021## 7-[(1R,3R,6R,7R)-3-(1,1-difluoropentyl)-3-hydroxy-2-oxabicyclo[4.3.0]nona- ne-8-one-7-yl]heptanoic acid, or a salt, ether, ester or amide thereof, in which the bi-cyclic compound is present in a ratio of substantially 100:0 with respect to its tautomeric monocyclic compound.

2. A bi-cyclic compound represented by the formula: ##STR00022## 7-[(1R,6R,7R)-3-[(3S)-1,1-difluoro-3-methylpentyl]-3-hydroxy-2-oxabicyclo- [4.3.0]nonane-8-one-7-yl]heptanoic acid or a salt, ether, ester or amide thereof, in which the bi-cyclic compound is present in a ratio of substantially 100:0 with respect to its tautomeric monocyclic compound.

3. The compound of claim 1, in which the bi-cyclic compound is: ##STR00023## 7-[(1R,3R,6R,7R)-3-(1,1-difluoropentyl)-3-hydroxy-2-oxabicyclo [4.3.0]nonane-8-one-7-yl]heptanoic acid.

4. The compound of claim 2, in which the bi-cyclic compound is: ##STR00024## 7-[(1R,6R,7R)-3-[(3S)-1,1-difluoro-3-methylpentyl]-3-hydroxy-2-oxabicyclo- [4.3.0]nonane-8-one-7-yl]heptanoic acid.
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