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Claims for Patent: 8,075,911

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Claims for Patent: 8,075,911

Title:Transparent transdermal nicotine delivery devices
Abstract: A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%.
Inventor(s): Gale; Robert M. (Los Altos, CA)
Assignee: Alza Corporation (Mt. View, CA)
Application Number:11/841,789
Patent Claims: 1. A device for transdermal administration of nicotine, comprising: a polymeric backing layer comprising a material selected from the group consisting of PET/EVA laminates, HDPE/EAA/nylon/EAA multilaminate and a film comprising a graft copolymer formed from 73-77% acrylonitrile and from 23-27% methyl acrylate copolymerized in the presence of 8-10 parts by weight of butadiene/acrylonitrile copolymers containing 70% by weight of polymer units derived from butadiene, a drug reservoir layer containing nicotine carried by the backing layer, and an adhesive for maintaining the device on the skin, wherein the device provides delivery of nicotine for a period of 18-24 hours and, as applied to the skin, exhibits an Opacity Index of less than 48.6% to permit the skin to which the device is applied to be visible through the device.

2. The device of claim 1 wherein the backing layer has a nicotine permeability of less than 1.0 .mu.g/cm.sup.2hr.

3. The device of claim 1, further wherein the Opacity Index of the device is less than 35.11%.

4. The device of claim 3, wherein the Opacity Index of the device is less than 20%.

5. The device of claim 1 wherein the backing comprises a PET/EVA laminate.

6. A device for transdermal nicotine administration, comprising: a laminate including a polymeric backing layer comprising a material selected from the group consisting of PET/EVA laminates, HDPE/EAA/nylon/EAA multilaminate and a film comprising a graft copolymer formed from 73-77% acrylonitrile and from 23-27% methyl acrylate copolymerized in the presence of 8-10 parts by weight of butadiene/acrylonitrile copolymers containing 70% by weight of polymer units derived from butadiene, a nicotine reservoir layer having nicotine carried by the backing layer, a rate control membrane near the nicotine reservoir to face the skin for controlling nicotine delivery to the skin, and adhesive for maintaining the device on the skin, wherein the device provides delivery of nicotine for a period of 18-24 hours and, as applied to the skin, exhibits an Opacity Index of less than 48.6% to permit the skin to which the device is applied to be visible through the device.
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