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Claims for Patent: 8,058,267

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Claims for Patent: 8,058,267

Title:Steroids as agonists for FXR
Abstract: The invention relates to compounds of formula (I): ##STR00001## wherein R is ethyl and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
Inventor(s): Pellicciari; Roberto (Perugia, IT)
Assignee: Intercept Pharmaceuticals, Inc. (New York, NY)
Application Number:12/547,147
Patent Claims: 1. A method for the treatment of cholestatic liver disease comprising administering to a mammal a therapeutically effective amount of a compound of formula I: ##STR00007## or a pharmaceutically acceptable salt or amino acid conjugates thereof, wherein R is ethyl.

2. The method according to claim 1, wherein the compound is the glycine conjugate of a compound of formula I.

3. The method according to claim 1, wherein the compound is the taurine conjugate of a compound of formula I.

4. The method according to claim 1, wherein the compound is the pharmaceutically acceptable salt of a compound of formula I.

5. The method according to claim 1, wherein the mammal is a human.
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