Claims for Patent: 8,053,448

Summary for Patent: 8,053,448

Title:	Biphenyl compounds useful as muscarinic receptor antagonists
Abstract:	This invention provides methods of using compounds of formula Ib below to treat pulmonary disorders. wherein: R4 is hydrogen or (1-4C)alkyl; q is 0, 1, or 2; R5 is independently selected from halo, (1-4C)alkyl, and (1-4C)alkoxy, wherein each alkyl and alkoxy group is optionally substituted with from 1 to 3 fluoro substituents; R7 is hydrogen or (1-4C)alkyl; or a pharmaceuticallly acceptable salt thereof.
Inventor(s):	Mathai Mammen, YuHua Ji, YongQi Mu, Craig Husfeld, Li Li
Assignee:	Theravance Biopharma R&D IP LLC
Application Number:	US13/024,532
Patent Claims:	1. A method of producing bronchodilation in a patient, the method comprising administering to a patient a bronchodilation-producing amount of a compound of formula Ib: wherein: R4 is hydrogen or (1-4C)alkyl; q is 0, 1 or 2; R5 is independently selected from halo, (1-4C)alkyl and (1-4C)alkoxy, wherein each alkyl and alkoxy group is optionally substituted with from 1 to 3 fluoro substituents; R7 is hydrogen or (1-4C)alkyl; or a pharmaceutically acceptable salt thereof. 2. A method of treating chronic obstructive pulmonary disease or asthma, the method comprising administering to a patient a therapeutically effective amount of a compound of formula Ib: wherein: R4 is hydrogen or (1-4C)alkyl; q is 0, 1 or 2; R5 is independently selected from halo, (1-4C)alkyl and (1-4C)alkoxy, wherein each alkyl and alkoxy group is optionally substituted with from 1 to 3 fluoro substituents; R7 is hydrogen or (1-4C)alkyl; or a pharmaceutically acceptable salt thereof.