.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 8,048,917

« Back to Dashboard

Claims for Patent: 8,048,917

Title:Prodrugs of GABA analogs, compositions and uses thereof
Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
Inventor(s): Gallop; Mark A. (Los Altos, CA), Cundy; Kenneth C. (Redwood City, CA), Zhou; Cindy X. (Palo Alto, CA), Yao; Fenmei (Mountain View, CA), Xiang; Jia-Ning (Palo Alto, CA)
Assignee: XenoPort, Inc. (Santa Clara, CA)
Application Number:11/110,909
Patent Claims: 1. A pharmaceutical composition comprising a compound of formula: ##STR00062## or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable vehicle, wherein: R.sup.7 and R.sup.14 are each hydrogen; R.sup.13 is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl and sec-butyl; and R.sup.25 is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, n-pentyl, isopentyl, sec-pentyl, neopentyl, and 1,1-diethoxyethyl.

2. The pharmaceutical composition of claim 1 wherein R.sup.13 is methyl.

3. The pharmaceutical composition of claim 1, wherein R.sup.25 is methyl, ethyl, n-propyl or isopropyl.

4. The pharmaceutical composition of any one of claims 1-3 which is an oral sustained release dosage form.

5. A compound having the formula: ##STR00063## or a pharmaceutically acceptable salt thereof.

6. A salt of a compound having the formula: ##STR00064##

7. A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt of claim 5 and a pharmaceutically acceptable vehicle.

8. An oral sustained release dosage form comprising the compound or pharmaceutically acceptable salt of claim 5 and a pharmaceutically acceptable vehicle.

9. A pharmaceutical composition comprising a compound having the formula: ##STR00065## and a pharmaceutically acceptable vehicle.

10. An oral sustained release dosage form of the compound having the formula: ##STR00066## and a pharmaceutically acceptable vehicle.

11. A method of treating neuropathic pain, comprising administering the compound or pharmaceutically acceptable salt of claim 5 to a patient in need thereof.

12. A method of treating neuropathic pain, comprising administering the pharmaceutical composition of claim 7 or the oral sustained release dosage form of claim 8 to a patient in need thereof.

13. A method of treating anxiety, comprising administering the compound or pharmaceutically acceptable salt of claim 5 to a patient in need thereof.

14. A method of treating anxiety, comprising administering the pharmaceutical composition of claim 7 or the oral sustained release dosage form of claim 8 to a patient in need thereof.

15. A method of treating ethanol withdrawal syndrome, comprising administering the compound or pharmaceutically acceptable salt of claim 5 to a patient in need thereof.

16. A method of treating ethanol withdrawal syndrome, comprising administering the pharmaceutical composition of claim 7 or the oral sustained release dosage form of claim 8, to a patient in need thereof.

17. A method of treating insomnia, comprising administering the compound or pharmaceutically acceptable salt of claim 5 to a patient in need thereof.

18. A method of treating insomnia, comprising administering the pharmaceutical composition of claim 7 or the oral sustained release dosage form of claim 8 to a patient in need thereof.

19. A method of treating epilepsy, comprising administering the compound or pharmaceutically acceptable salt of claim 5 to a patient in need thereof.

20. A method of treating epilepsy, comprising administering the pharmaceutical composition of claim 7 or the oral sustained release dosage form of claim 8 to a patient in need thereof.

21. A method of treating neuropathic pain, comprising administering the compound of formula: ##STR00067## to a patient in need thereof.

22. A method of treating neuropathic pain, comprising administering the pharmaceutical composition of claim 9 or the oral sustained release dosage form of claim 10 to a patient in need thereof.

23. A method of treating anxiety, comprising administering the compound of formula: ##STR00068## to a patient in need thereof.

24. A method of treating anxiety, comprising administering the pharmaceutical composition of claim 9 or the oral sustained release dosage form of claim 10 to a patient in need thereof.

25. A method of treating ethanol withdrawal syndrome, comprising administering the compound of formula: ##STR00069## to a patient in need thereof.

26. A method of treating ethanol withdrawal syndrome, comprising administering the pharmaceutical composition of claim 9 or the oral sustained release dosage form of claim 10 to a patient in need thereof.

27. A method of treating insomnia, comprising administering the compound of formula: ##STR00070## to a patient in need thereof.

28. A method of treating insomnia, comprising administering the pharmaceutical composition of claim 9 or the oral sustained release dosage form of claim 10 to a patient in need thereof.

29. A method of treating epilepsy, comprising administering the compound of formula: ##STR00071## to a patient in need thereof.

30. A method of treating epilepsy, comprising administering the pharmaceutical composition of claim 9 or the oral sustained release dosage form of claim 10 to a patient in need thereof.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc