|Title:||Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents|
|Abstract:||The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compound. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) compounds of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.|
|Inventor(s):||Woodward; David F. (El Toro, CA), Andrews; Steven W. (Irvine, CA), Burk; Robert M. (Irvine, CA), Garst; Michael E. (Newport Beach, CA)|
|Assignee:||Allergan, Inc. (Irvine, CA)|
1. A pharmaceutical composition comprising cyclopentane N-ethyl hepteneamide-5-cis-2-(3.alpha.-hydroxy-5-phenyl-1-trans-pentenyl)-3, 5-dihydroxy,
[1.sub..alpha.2.sub..beta.3.sub..alpha.5.sub..alpha.], benzalkonium chloride, and sodium chloride as a tonicity agent.
2. The pharmaceutical composition of claim 1, wherein the composition is for ophthalmic application.
3. The pharmaceutical composition of claim 2, wherein the composition is packaged in a dropper for ophthalmic application.
4. The pharmaceutical composition of claim 1, wherein the pH of the composition is 4.5-7.5.
5. The pharmaceutical composition of claim 1, for use in lowering intraocular pressure of the eye.
6. The pharmaceutical composition of claim 1, for treatement of glaucoma.
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