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Claims for Patent: 7,994,185

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Claims for Patent: 7,994,185

Title:Benzene sulfonamide thiazole and oxazole compounds
Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
Inventor(s): Rheault; Tara Renae (Durham, NC)
Assignee: Glaxo Smith Kline LLC (Philadelphia, PA)
Application Number:12/434,963
Patent Claims: 1. A compound of formula ##STR00609## or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition, comprising a compound of claim 1, together with one or more of pharmaceutically acceptable carriers, diluents or excipients.

3. A pharmaceutical composition as claimed in claim 2 in unit dosage form.

4. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 1.

5. The method of claim 4, wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution.

6. A compound of formula ##STR00610##

7. A pharmaceutical composition, comprising a compound of claim 6, together with one or more of pharmaceutically acceptable carriers, diluents or excipients.

8. A pharmaceutical composition as claimed in claim 7 in unit dosage form.

9. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 6.

10. The method of claim 9, wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution.

11. A pharmaceutically acceptable salt of the compound of formula ##STR00611##

12. A pharmaceutical composition, comprising a compound of claim 11, together with one or more of pharmaceutically acceptable carriers, diluents or excipients.

13. A pharmaceutical composition as claimed in claim 12 in unit dosage form.

14. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 11.

15. The method of claim 14, wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution.

16. N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-y- l]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide mesylate.

17. A pharmaceutical composition, comprising a compound of claim 16, together with one or more of pharmaceutically acceptable carriers, diluents or excipients.

18. A pharmaceutical composition as claimed in claim 16 in unit dosage form.

19. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 16.

20. The method of claim 19, wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution.
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