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|Title:||Methods and compositions for deterring abuse of drugs susceptible to abuse and dosage forms thereof|
|Abstract:||This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.|
|Inventor(s):||Kumar; Vijai (Morris Plains, NJ), Dixon; David (Woodside, NY), Tewari; Divya (Suffern, NY), Wadgaonkar; Dilip B. (Suffern, NY)|
|Assignee:||Acura Pharmaceuticals, Inc. (Palatine, IL)|
1. A therapeutic pharmaceutical composition comprising: a mixture including (a) a water soluble drug susceptible to abuse; (b) polyethylene oxide at about 3 to about 40
percent by weight; (c) a disintegrant at about 2 to 25 percent by weight wherein the disintegrant is selected from the group consisting of crospovidone, sodium starch glycolate, and croscarmellose sodium; and (d) sodium lauryl sulfate at about 1 to 10
percent by weight.
2. The therapeutic pharmaceutical composition of claim 1, further comprising an emetic.
3. The therapeutic pharmaceutical composition of claim 2, wherein the emetic is zinc sulfate.
4. The therapeutic pharmaceutical composition of claim 1, wherein the polyethylene oxide has an average molecular weight ranging from 300,000 to about 5,000,000.
5. The therapeutic pharmaceutical composition of claim 1, wherein the pharmaceutical composition is in unit dose form.
6. The therapeutic pharmaceutical composition of claim 1, wherein the pharmaceutical composition is in suppository, capsule, caplet, pill, gel, soft gelatin capsule, or compressed tablet form.
7. The therapeutic pharmaceutical composition of claim 1, wherein the water soluble drug susceptible to abuse is present in an amount of 0.5 to about 25 percent by weight.
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