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Claims for Patent: 7,973,040

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Claims for Patent: 7,973,040

Title:Macrocyclic quinoxaline compounds as HCV NS3 protease inhibitors
Abstract: The present invention relates to macrocyclic a compound of formula (I) and its use as inhibitors of the hepatitis C virus (HCV) NS3 protease, and in treating or preventing HCV infections. ##STR00001##
Inventor(s): Harper; Steven (Rome, IT), Summa; Vincenzo (Rome, IT), Liverton; Nigel J. (Harleysville, PA), McCauley; John A. (Maple Glen, PA)
Assignee: Merck Sharp & Dohme Corp. (Rahway, NJ) Istituto di Ricerche di Biologia Molecolare P. Angeletti SpA (Rome, IT)
Application Number:12/504,955
Patent Claims: 1. A compound having the structure: ##STR00029## or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising an effective amount of the compound of claim 1 and a pharmaceutically acceptable carrier.

3. The pharmaceutical composition of claim 2, further comprising a second therapeutic agent selected from the group consisting of a HCV protease inhibitor and a HCV NS5B polymerase inhibitor.

4. A method of treating a patient infected with HCV comprising the step of administering to said patient an effective amount of the compound according to claim 1.

5. A method of treating a patient infected with HCV comprising the step of administering to said patient an effective amount of the composition according to claim 2.

6. A method of treating a patient infected with HCV comprising the step of administering to said patient an effective amount of the composition according to claim 3.

7. A compound having structure: ##STR00030##

8. A pharmaceutical composition comprising an effective amount of the compound of claim 7 and a pharmaceutically acceptable carrier.

9. The pharmaceutical composition of claim 8, further comprising a second therapeutic agent selected from the group consisting of a HCV protease inhibitor and a HCV NS5B polymerase inhibitor.

10. A method of treating a patient infected with HCV comprising the step of administering to said patient an effective amount of the compound according to claim 7.

11. A method of treating a patient infected with HCV comprising the step of administering to said patient an effective amount of the composition according to claim 8.

12. A method of treating a patient infected with HCV comprising the step of administering to said patient an effective amount of the composition according to claim 9.
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