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Serving 500+ biopharmaceutical companies globally:

Johnson and Johnson
Queensland Health
US Department of Justice
Federal Trade Commission
Fish and Richardson

Generated: June 26, 2017

DrugPatentWatch Database Preview

Claims for Patent: 7,964,212

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Claims for Patent: 7,964,212

Title:Effervescent compositions comprising phosphonates and methods related thereto
Abstract: The invention provides effervescent composition comprising a bisphosphonate, an acidic compound, an alkaline effervescing component, and optionally an anti-ulcer agent and methods of treating osteoporosis in a mammal using the effervescent compositions.
Inventor(s): Rosen; Christer (Jupiter, FL)
Application Number:12/367,928
Patent Claims: 1. An effervescent composition comprising: (a) 50 mg to 120 mg of a bisphosphonate (b) citric acid, and (c) an alkaline effervescing component which is a carbonate salt or a bicarbonate salt, wherein the composition has a total weight of 3500 mg to about 6000 mg and when dissolved in water produces a solution having a buffered pH of about 4 to about 6.5 and has buffering capacity sufficient to mediate the pH of a patient's stomach for at least 15 minutes.

2. The composition of claim 1, wherein the bisphosphonate is selected from the group consisting of etidronate, risedronate, ibandronate, alendronate, and combinations thereof.

3. The composition of claim 1, wherein the bisphosphonate is alendronate and said buffering capacity sufficient to mediate the pH of a patient's stomach for at least 30 minutes.

4. The composition of claim 1, wherein the dissolved buffered solution is capable of mediating the pH of a patient's stomach for at least about 30 minutes or more.

5. The composition of claim 1, wherein the alkaline effervescing component comprises a carbonate salt and a bicarbonate salt.

6. The composition of claim 1, wherein the acid component and the alkaline effervescing component are at least partially reacted with each other during granulation with the bisphosphonate.
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Serving 500+ biopharmaceutical companies globally:

Boehringer Ingelheim
Fish and Richardson
Cantor Fitzgerald

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