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|Title:||Method for treatment of common acne|
|Abstract:||Dermatological/cosmetic compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise, in a physiologically acceptable medium, (i) at least one dispersed retinoid, (ii) dispersed benzoyl peroxide, in free or encapsulated form, and (iii) at least one pH-independent gelling agent, said dermatological/cosmetic composition having physical stability without loss of viscosity over time at a temperature ranging from 4.degree. C. to 40.degree. C., said dermatological/cosmetic composition having a stable flow threshold over time as measured by viscosity measurements for rheograms which measure a shear stress .tau. for a given rate gradient .gamma. and which measure a rate gradient .gamma. for a given shear stress .tau., the yield value (.tau.0) being extrapolated visually or by calculation.|
|Inventor(s):||Orsoni; Sandrine (Mandelieu, FR), Willcox; Nathalie (Le Rouret, FR)|
|Assignee:||Galderma Research & Development, S.N.C. (FR)|
1. A method for treating common acne comprising administering once-daily, to a subject in need thereof, a physiologically acceptable aqueous gel composition for treatment of
common acne comprising anti-acne actives consisting of 0.1% adapalene and/or at least one pharmaceutically acceptable salt thereof, 2.5% dispersed benzoyl peroxide, and further comprising 4% acrylamide sodium acryloyldimethyltaurate
copolymer/isohexadecane/polysorbate 80 gelling agent, said percentages being based on the total weight of the aqueous gel composition.
2. A product for the once-daily treatment of acne comprising: a container; and a physiologically acceptable aqueous gel composition for once-daily treatment of common acne comprising anti-acne actives consisting of 0.1% adapalene and/or at least one pharmaceutically acceptable salt thereof, and 2.5% dispersed benzoyl peroxide, and further comprising 4% acrylamide sodium acryloyldimethyltaurate copolymer/isohexadecane/polysorbate 80 gelling agent, said percentages being based on the total weight of the aqueous gel composition, wherein the container contains the aqueous gel composition.
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