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Claims for Patent: 7,910,610

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Claims for Patent: 7,910,610

Title:Methods of administering pirfenidone therapy
Abstract: The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.
Inventor(s): Bradford; Williamson Ziegler (Ross, CA), Szwarcberg; Javier (San Francisco, CA)
Assignee: Intermune, Inc. (Brisbane, CA)
Application Number:12/901,245
Patent Claims: 1. A method of administering pirfenidone therapy to a patient in need thereof, comprising administering to the patient a therapeutically effective amount of pirfenidone while avoiding co-administration of a strong cytochrome P450 1A2 (CYP1A2) inhibitor, wherein said patient is also in need of therapy with a strong CYP1A2 inhibitor.

2. The method of claim 1 wherein the patient has idiopathic pulmonary fibrosis (IPF).

3. The method of claim 1 wherein the therapeutically effective amount of pirfenidone is a daily dosage of 2400 mg or 2403 mg per day.

4. The method of claim 1 wherein 800 or 801 mg of pirfenidone is administered to the patient three times per day, with food.

5. A method of administering pirfenidone therapy to a patient in need thereof, comprising discontinuing administration of a strong CYP1A2 inhibitor to avoid an adverse drug interaction with pirfenidone, and administering to the patient a therapeutically effective amount of pirfenidone.

6. The method of claim 5 wherein the patient has idiopathic pulmonary fibrosis (IPF).

7. The method of claim 5 wherein the therapeutically effective amount of pirfenidone is a daily dosage of 2400 mg or 2403 mg per day.

8. The method of claim 5 wherein 800 or 801 mg of pirfenidone is administered to the patient three times per day, with food.

9. The method of claim 5 wherein the strong CYP1A2 inhibitor is discontinued within 1 month prior to starting pirfenidone therapy.

10. The method of claim 5 wherein the strong CYP1A2 inhibitor is discontinued within 2 weeks prior to starting pirfenidone therapy.

11. The method of claim 1 or 5 wherein the patient is advised that co-administration of pirfenidone with the strong CYP1A2 inhibitor can alter the therapeutic effect or adverse reaction profile of pirfenidone.
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