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Generated: February 18, 2018

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Claims for Patent: 7,906,519

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Summary for Patent: 7,906,519
Title:Methods for concomitant administration of colchicine and a second active agent
Abstract:Methods for concomitant administration of colchicine together with one or more second active agents, e.g., ketoconazole and ritonavir, are disclosed. Such methods reduce the dangers commonly associated with such concomitant administration and provide additional benefits. Methods of notifying health care practitioners and patients regarding appropriate dosing for concomitant administration of colchicine together with second active agents are also provided.
Inventor(s): Davis; Matthew W. (Erwinna, PA)
Assignee: AR Holding Company, Inc. (Wilmington, DE)
Application Number:12/858,754
Patent Claims: 1. A method of treating a patient in need of treatment for Familial Mediterranean Fever with colchicine, comprising orally administering to the patient in need of treatment for Familial Mediterranean Fever, an adjusted daily dosage amount of colchicine wherein the patient is receiving concomitant administration of 200 mg per day of ritonavir, wherein the adjusted daily dosage amount of colchicine is a maximum colchicine dosage amount of 0.6 mg of colchicine per day which is a reduction from an intended daily dosage amount of colchicine in the absence of concomitant ritonavir as follows: TABLE-US-00021 Daily dosage amount Age Usual Maximum Adults and children >12 years 1.2 mg 2.4 mg Children >6 to 12 years 0.9 mg 1.8 mg Children 4 to 6 years 0.3 mg 1.8 mg

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