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Claims for Patent: 7,888,342

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Claims for Patent: 7,888,342

Title:Methods of treating fibromyalgia syndrome, chronic fatigue syndrome and pain
Abstract:The present invention provides a method of treating fibromyalgia syndrome (FMS), chronic fatigue syndrome (CFS), and pain in an animal subject. The method generally involves administering a therapeutically effective amount of a dual serotonin norepinephrine reuptake inhibitor compound or a pharmaceutically acceptable salt thereof, wherein said dual serotonin norepinephrine reuptake inhibitor compound is characterized by a non-tricyclic structure and an equal or greater inhibition of norepinephrine reuptake than serotonin reuptake. In particular, the use of milnacipran to treat FMS, CFS, and pain is disclosed.
Inventor(s): Kranzler; Jay D. (La Jolla, CA), Rao; Srinivas G. (Encinitas, CA)
Assignee: Cypress Bioscience, Inc. (San Diego, CA)
Application Number:12/644,510
Patent Claims: 1. A method of treating fibromyalgia, the method consisting essentially of administering to a patient in need thereof an effective amount of at least one compound selected from milnacipran, a pharmaceutically acceptable salt of milnacipran, or a combination thereof, with the proviso that the method excludes administering phenylalanine, tyrosine, or tryptophan.

2. A method of treating fibromyalgia, the method consisting essentially of administering to a patient in need thereof a daily dose of about 100 mg of active ingredient, wherein the active ingredient is at least one compound selected from milnacipran, a pharmaceutically acceptable salt of milnacipran, or a combination thereof, with the proviso that the method excludes administering phenylalanine, tyrosine, or tryptophan.

3. The method of claim 2, wherein the active ingredient is in tablet form.

4. The method of claim 2, wherein the daily dose of active ingredient is divided into multiple doses per day.

5. The method of claim 4, wherein the daily dose of active ingredient is administered as a 50 mg dose twice per day.

6. A method of treating fibromyalgia, the method consisting essentially of administering to a patient in need thereof a daily dose of about 200 mg of active ingredient, wherein the active ingredient is at least one compound selected from milnacipran, a pharmaceutically acceptable salt of milnacipran, or a combination thereof, with the proviso that the method excludes administering phenylalanine, tyrosine, or tryptophan.

7. The method of claim 6, wherein the active ingredient is in tablet form.

8. The method of claim 6, wherein the daily dose of active ingredient is divided into multiple doses per day.

9. The method of claim 8, wherein the daily dose of active ingredient is administered as a 100 mg dose twice per day.

10. The method of claim 9, wherein the daily dose of active ingredient is administered as two 50 mg doses in the morning and two 50 mg doses in the evening.
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