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Claims for Patent: 7,872,050

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Claims for Patent: 7,872,050

Title:Stabilized compositions of volatile alkylating agents and methods of using thereof
Abstract: A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.
Inventor(s): Alonso; Robert (Philadelphia, PA), Crooks; Peter A. (Nicholasville, KY), Pimley; Mark A. (Glenmoore, PA)
Assignee: Yaupon Therapeutics Inc. (Radnor, PA)
Application Number:11/369,305
Patent Claims: 1. A method for treating a person with a skin disorder, comprising: topically applying to the affected skin a composition comprising: an active pharmaceutical ingredient, wherein the active pharmaceutical ingredient consists essentially of a pharmaceutically acceptable salt of bis(2-chloroethyl)methylamine; a vehicle or carrier that is a compound of the formula HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2OR.sub.79, wherein R.sub.79 is a linear alkyl group having 1-6 carbon atoms; and an organic acid in an amount of about 1 percent to about 15 percent by weight of the composition, wherein the skin disorder is psoriasis, mycosis fungoides, or alopecia.

2. The method of claim 1, wherein the pharmaceutically acceptable salt of bis(2-chloroethyl)methylamine is present in an amount of about 0.0001 to about 2.0 weight percent of the composition.

3. The method of claim 1, wherein the pharmaceutically acceptable salt of bis(2-chloroethyl)methylamine is present in an amount of about 0.01 to about 0.04 weight percent of the composition.

4. The method of claim 1, wherein the pharmaceutically acceptable salt of bis(2-chloroethyl)methylamine is present in an amount of about 0.015 to about 0.030 weight percent of the composition.

5. The method of claim 1, wherein the organic acid is oxalic acid, p-bromophenylsulfonic acid, carbonic acid, succinic acid, citric acid, benzoic acid, 2-acetoxybenzoic acid, acetic acid, phenylacetic acid, propionic acid, glycolic acid, stearic acid, lactic acid, malic acid, tartaric acid, ascorbic acid, maleic acid, hydroxymaleic acid, glutamic acid, salicylic acid, sulfanilic acid, or fumaric acid.

6. The method of claim 1, wherein the organic acid is lactic acid.

7. The method of claim 1, wherein the vehicle or carrier is a compound of the formula HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2OR.sub.79, wherein R.sub.79 is a linear alkyl group having 2 carbon atoms (Ethoxy Diglycol Reagent).

8. The method of claim 1, wherein the skin disorder is mycosis fungoides.

9. The method of claim 1, wherein the skin disorder is psoriasis.

10. The method of claim 1, wherein the skin disorder is alopecia.

11. The method of claim 1, wherein the vehicle or carrier is a non-aqueous vehicle or carrier.

12. The method of claim 11, wherein the non-aqueous vehicle or carrier is a compound of the formula HOCH.sub.2CH.sub.2OCH.sub.2CH.sub.2OR.sub.79, wherein R.sub.79 is a linear alkyl group having 2 carbon atoms (Ethoxy Diglycol Reagent).

13. The method of claim 7, wherein the organic acid is lactic acid.

14. The method of claim 12, wherein the organic acid is lactic acid.
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