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|Title:||Enhanced bimatoprost ophthalmic solution|
|Abstract:||A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein.A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.|
|Inventor(s):||Chang; Chin-Ming (Tustin, CA), Chang; James N. (Newport Beach, CA), Schiffman; Rhett M. (Laguna Beach, CA), Jordan; R. Scott (Trabuco Canyon, CA), Chang-Lin; Joan-En (Tustin, CA)|
|Assignee:||Allergan, Inc. (Irvine, CA)|
1. A composition having a pH of about 7.3 which consists essentially of about 0.01% bimatoprost, about 200 ppm benzalkonium chloride, a phosphate buffer, NaCl, and water,
wherein said composition is an aqueous liquid which is formulated for ophthalmic administration.
2. A composition having a pH of about 7.3 which comprises about 0.01% bimatoprost, about 200 ppm benzalkonium chloride, citric acid monohydrate, a phosphate buffer, and NaCl wherein said composition is an aqueous liquid which is formulated for ophthalmic administration.
3. A composition having a pH of about 7.3 which comprises about 0.01% bimatoprost, 200 ppm benzalkonium chloride, about 0.014 citric acid monohydrate, a phosphate buffer, NaCl, and water wherein said composition is an aqueous liquid which is formulated for ophthalmic administration.
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