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|Title:||Ketorolac tromethamine compositions for treating ocular pain|
|Abstract:||The present invention provides an aqueous ophthalmic solution having an effective amount of ketorolac which includes carboxymethyl cellulose in an aqueous solution wherein the concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye of a patient that is at least 130% greater than the absorption of a comparative aqueous ketorolac ophthalmic solution having the same concentration of ketorolac.|
|Inventor(s):||Farnes; Eldon Q. (Laguna Beach, CA), Attar; Mayssa (Placentia, CA), Schiffman; Rhett M. (Laguna Beach, CA), Chang; Chin-Ming (Tustin, CA), Graham; Richard S. (Irvine, CA), Welty; Devin F. (Foothill Ranch, CA)|
|Assignee:||Allergan, Inc. (Irvine, CA)|
1. A topical aqueous ophthalmic solution having the following components: a. 0.45% w/v ketorolac tromethamine; b. about 0.325% w/v carboxymethyl cellulose, medium viscosity; c. about 0.175% w/v carboxymethyl cellulose, high viscosity; d. about 0.7% w/v NaCl; e. about 0.2% w/v sodium citrate dihydrate; f. at least one buffer selected from the group consisting of sodium hydroxide (1N) and hydrochloric acid (1N) to adjust
the pH to about 6.8; and g. water.
2. A topical aqueous ophthalmic solution having the following components: a. ketorolac tromethamine 0.45% w/v; b. carboxymethyl cellulose, medium viscosity 0.325% w/v; c. carboxymethyl cellulose, high viscosity 0.175% w/v; d. sodium citrate dihydrate 0.2% w/v; e. at least one buffer to adjust the pH to about 6.8; and f. water.
3. A topical aqueous ophthalmic solution having the following components: a. ketorolac tromethamine 0.45% w/v; b. carboxymethyl cellulose, medium viscosity 0.325% w/v; c. carboxymethyl cellulose, high viscosity 0.175% w/v; d. NaCl 0.7% w/v; e. sodium citrate dihydrate 0.2% w/v; f. sodium hydroxide (1N) and hydrochloric acid (1N) to adjust the pH to 6.8; and g. water.
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