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Claims for Patent: 7,834,059

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Claims for Patent: 7,834,059

Title:Topical nepafenac formulations
Abstract:Topical suspension compositions of nepafenac are disclosed. The compositions are especially suitable for topical ophthalmic administration.
Inventor(s): Wong; Warren (Fort Worth, TX)
Assignee: Alcon, Inc. (Hunenberg, CH)
Application Number:11/292,484
Patent Claims: 1. A method of treating ophthalmic inflammatory disorders in a human patient comprising topically administering to the patient a composition consisting of a) 0.1% (w/v) nepafenac; b) 0.5% (w/v) carbomer; c) 0.01% (w/v) tyloxapol; d) 0.4% (w/v) sodium chloride; e) 2.4% (w/v) mannitol; f) a pH-adjusting agent in an amount sufficient to cause the composition to have a pH of 7.3-7.7; g) 0.005% (w/v) benzalkonium chloride; h) 0.01% edetate disodium; and i) purified water.

2. In a method of treating ophthalmic inflammatory disorders in a human patient comprising topically administering to the patient an aqueous suspension composition comprising nepafenac, the improvement wherein the composition consists of a) 0.1% (w/v) nepafenac; b) 0.5% (w/v) carbomer; c) 0.01% (w/v) tyloxapol; d) 0.4% (w/v) sodium chloride; e) 2.4% (w/v) mannitol; f) a pH-adjusting agent in an amount sufficient to cause the composition to have a pH of 7.3-7.7; g) 0.005% (w/v) benzalkonium chloride; h) 0.01% edetate disodium; and i) purified water.
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