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|Title:||Method of treating abnormal cell growth|
|Abstract:||The present invention relates to the use of (R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-py- razol-4-yl)-pyridin-2-ylamine, a novel c-Met/HGFR inhibitor, for treating abnormal cell growth in mammals. In particular, the invention provides methods of treating mammals suffering from cancer.|
|Inventor(s):||Christensen; James Gail (San Diego, CA), Zou; Yahong (San Diego, CA)|
|Assignee:||Pfizer Inc. (New York, NY)|
1. A method of reversing or inhibiting the progress of abnormal cell growth in a mammal comprising, administering to said mammal a therapeutically effective amount of
(R)-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-py- razol-4-yl)-pyridin-2-ylamine or a pharmaceutically acceptable salt thereof, wherein the abnormal cell growth is a cancer mediated by an anaplastic lymphoma kinase.
2. The method of claim 1, wherein the mammal is a human.
3. The method of claim 1, wherein the mammal is a dog.
4. The method of claim 1, wherein the anaplastic lymphoma kinase is a genetically altered anaplastic lymphoma kinase.
5. The method of claim 1, wherein the cancer is selected from the group consisting of non-small cell lung cancer (NSCLC), squamous cell carcinoma, hormone-refractory prostate cancer, papillary renal cell carcinoma, colorectal adenocarcinoma, neuroblastomas, anaplastic large cell lymphoma (ALCL) and gastric cancer.
6. The method of claim 1, wherein (R)-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-py- razol-4-yl)-pyridin-2-ylamine or pharmaceutically acceptable salt thereof is administered as a pharmaceutical composition comprising (R)-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-py- razol-4-yl)-pyridin-2-ylamine or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable carrier.
7. The method of claim 2, wherein the anaplastic lymphoma kinase is a genetically altered anaplastic lymphoma kinase.
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