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Last Updated: December 6, 2019

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Claims for Patent: 7,786,133

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Summary for Patent: 7,786,133
Title:Chemically modified small molecules
Abstract: The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.
Inventor(s): Bentley; Michael D. (Huntsville, AL), Viegas; Tacey X. (Madison, AL), Goodin; Richard R. (Fayerville, TN), Cheng; Lin (Huntsville, AL), Zhao; Xuan (Huntsville, AL)
Assignee: Nektar Therapeutics (San Carlos, CA)
Application Number:11/015,196
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 7,786,133
Patent Claims: 1. 6-CH.sub.3--(OCH.sub.2CH.sub.2).sub.7--O-Naloxol or a pharmaceutically acceptable salt thereof.

2. .alpha.-6-CH.sub.3--(OCH.sub.2CH.sub.2).sub.7--O-Naloxol or a pharmaceutically acceptable salt thereof.

3. .beta.-6-CH.sub.3--(OCH.sub.2CH.sub.2).sub.7--O-Naloxol or a pharmaceutically acceptable salt thereof.

4. A pharmaceutical composition comprising the compound of any one of claims 1-3, or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

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