.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 7,741,358

« Back to Dashboard

Claims for Patent: 7,741,358

Title:Crystal form of asenapine maleate
Abstract:The invention relates to an orthorhombic crystal form of compound trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz [2,3:6,7]oxepino[4,5-c]pyrrole (Z)-2-butenedioate, to methods for the preparation of this crystal form and to pharmaceutical compositions comprising an orthorhombic crystal form.
Inventor(s): Heeres; Gerhardus Johannes (Oss, NL)
Assignee: N.V. Organon (Oss, NL)
Application Number:11/399,204
Patent Claims: 1. Orthorhombic trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4- ,5-c]pyrrole (Z)-2-butenedioate isolated in a form which contains at least about 90 wt. % of the orthorhombic crystalline form.

2. The compound according to claim 1 which is characterized by an X-ray powder diffraction pattern obtained with CuK.alpha. radiation with peaks at values of 2-theta (2.theta.) of 10.5.degree., 15.7.degree., 18.3.degree., 19.0.degree., 22.2.degree., 23.2.degree. and 27.5.degree..

3. The compound according to claim 1 which is characterized by an X-ray powder diffraction pattern obtained with CuK.alpha. radiation with peaks at values of 2-theta (2.theta.) of 10.5.degree., 15.7.degree., 18.3.degree., 19.0.degree., 20.3.degree., 20.8.degree., 22.2.degree., 23.2.degree., 25.6.degree. and 27.5.degree..

4. The compound according to claim 1 which is characterized by a Raman spectroscopic pattern with peaks at values of 3051 cm.sup.-1, 3029 cm.sup.-1, 3011 cm.sup.-1, 2888 cm.sup.-1, 824 cm.sup.-1 and 717 cm.sup.-1.

5. The compound according to claim 1 which is characterized by a Raman spectroscopic pattern with peaks at values of 3072 cm.sup.-1, 3051 cm.sup.-1, 3029 cm.sup.-1, 3011 cm.sup.-1, 2909 cm.sup.-1, 2888 cm.sup.-1, 1245 cm.sup.-1, 824 cm.sup.-1, 747 cm.sup.-1, 717 cm.sup.-1 and 194 cm.sup.-1.

6. A method of preparation of the compound according to claim 1 characterized in that trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz [2,3:6,7]oxepino[4,5-c]pyrrole (Z)-2-butenedioate is crystallized from an ethanol/water mixture.

7. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz [2,3:6,7]oxepino[4,5-c]pyrrole (Z)-2-butenedioate in the orthorhombic crystal form, wherein said composition is prepared by using the trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4- ,5-c]pyrrole (Z)-2-butenedioate of claim 1.

8. A method of treating a mental disorder selected from schizophrenia and bipolar disorder in a mammal, comprising administering a therapeutically effective amount of a composition of claim 7.

9. The method according to claim 8, wherein the mammal is a human.

10. Then method according to claim 8, wherein the mental disorder is schizophrenia.

11. The method according to claim 8, wherein the mental disorder is bipolar disorder.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc