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Generated: March 18, 2018

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Claims for Patent: 7,741,338

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Summary for Patent: 7,741,338
Abstract: The invention relates to the stabilization of poly-ene macrolides and to a particular macrolide obtained in crystalline form.
Inventor(s): Navarro; Francois (Bruebach, FR), Petit; Samuel (Mont Saint-Aignan, FR), Stone; Guy (Crosshaven, IE)
Assignee: Novartis AG (Basel, CH)
Application Number:12/497,728
Patent Claims: 1. A solid mixture comprising 40-O-(2-hydroxy)ethyl-rapamycin and 2,6-di-tert-butyl-methylphenol (BHT).

2. A mixture according to claim 1, wherein said 2,6-di-tert-butyl-4-methylphenol (BHT) is present in a catalytic amount.

3. A pharmaceutical composition comprising the solid mixture of claim 1 together with one or more pharmaceutically acceptable diluent or carrier.

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