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Last Updated: November 28, 2020

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Claims for Patent: 7,728,143

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Summary for Patent: 7,728,143
Title:Salt and crystalline forms thereof of a drug
Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
Inventor(s): Zhang; Geoff G. Z. (Libertyville, IL), Bradley; Michael F. (Covington, WA), Barnes; David M. (Lake Villa, IL), Henry; Rodger (Wildwood, IL)
Assignee: Abbott Laboratories (Abbott Park, IL)
Application Number:11/245,561
Patent Claims: 1. D-Glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-h- ydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate trihydrate salt.

2. Crystalline D-glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-h- ydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate salt characterized, when measured at about 25.degree. C. with Cu--K.alpha. radiation, by the powder diffraction pattern shown in FIG. 1.

3. Crystalline D-glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-h- ydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate trihydrate salt characterized, when measured at about 25.degree. C. with Cu--K.alpha. radiation, by the powder diffraction pattern shown in FIG. 2.

4. A process for making D-glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-h- ydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate salt comprising dehydrating D-glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-h- ydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate trihydrate salt.

5. D-Glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-h- ydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate salt prepared as described in claim 4.

6. A process for making D-glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-h- ydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate trihydrate salt by crystallization of D-glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoro-pyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-- hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate salt from water, with or without an alcohol.

7. D-Glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-h- ydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate trihydrate salt prepared as described in claim 6.

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