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Claims for Patent: 7,709,517

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Claims for Patent: 7,709,517

Title:Diarylhydantoin compounds
Abstract: The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
Inventor(s): Sawyers; Charles L. (New York, NY), Jung; Michael E. (Los Angeles, CA), Chen; Charlie D. (Los Angeles, CA), Ouk; Samedy (Costa Mesa, CA), Welsbie; Derek (Northridge, CA), Tran; Chris (New York, NY), Wongvipat; John (Nanuet, NY), Yoo; Dongwon (Los Angeles, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Application Number:11/433,829
Patent Claims: 1. A compound selected from the group consisting of ##STR00238##

2. The compound of claim 1 having the formula ##STR00239##

3. The compound of claim 1, having the formula ##STR00240##

4. The compound of claim 1, having the formula ##STR00241##

5. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 2, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent.

6. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 3, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent.

7. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 4, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent.

8. A pharmaceutical acceptable salt of a compound according to claim 1.

9. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1, or a pharmaceutically acceptable salt of a compound of claim 1, and a pharmaceutically acceptable carrier or diluent.

10. A pharmaceutical composition according to claim 9, wherein the compound is dissolved.

11. A pharmaceutical composition according to claim 9, comprising a solvent.

12. A pharmaceutical composition according to claim 9 comprising one or more of dimethylsulfoxide (DSMO), polyethylene glycol (PEG), and water.

13. A pharmaceutical composition according to claim 9, dimethylsulfoxide (DSMO), polyethylene glycol (PEG), and water.
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