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|Title:||Modified release formulations of a bupropion salt|
|Abstract:||The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.|
|Inventor(s):||Oberegger; Werner (Mississauga, CA), Zhou; Fang (Davie, FL), Maes; Paul (Toronto, CA), Jackson; Graham (Co. Kildare, IE), Saleh; Mohammad Ashty (Oakville, CA)|
|Assignee:||Biovail Laboratories International S.R.L. (St. Michael, BB)|
1. A composition comprising bupropion hydrobromide and at least one controlled release polymer that reduces the ratio of the maximum/minimum plasma bupropion hydrobromide concentration
(Cmax/Cmin) while maintaining bupropion plasma levels within the therapeutic window upon administration to a patient.
2. A composition comprising bupropion hydrobromide and and at least one controlled release polymer that controls the release of the bupropion hydrobromide upon administration to a patient to provide plasma concentrations of the bupropion hydrobromide within a therapeutic range over a 24 hour period.
3. A composition comprising bupropion hydrobromide and at least one controlled release polymer that releases the bupropion hydrobromide upon administration to a patient to provide a time delay between administration and the commencement of bupropion hydrobromide-release in the external environment of use.
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