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Summary for Patent: 7,645,789
|Title:||Indole derivatives as CFTR modulators|
|Abstract:||Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.|
|Inventor(s):||Hadida Ruah; Sara S. (La Jolla, CA), Grootenhuis; Peter D. J. (San Diego, CA), Van Goor; Fredrick (San Diego, CA), Zhou; Jinglan (San Diego, CA), Bear; Brian (Oceanside, CA), Miller; Mark T. (San Diego, CA), McCartney; Jason (Cardiff by the Sea, CA), Numa; Mehdi Michel Djamel (San Diego, CA)|
|Assignee:||Vertex Pharmaceuticals Incorporated (Cambridge, MA)|
1. A compound of formula: ##STR00853## or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising (i) a compound of formula: ##STR00854## (ii) a pharmaceutically acceptable carrier.
3. The composition of claim 2, further comprising an additional agent wherein the additional agent is N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide.
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