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Claims for Patent: 7,642,258

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Claims for Patent: 7,642,258

Title:Combination of brimonidine and timolol for topical ophthalmic use
Abstract:Disclosed are pharmaceutical compositions comprising brimondine and timolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for glaucoma and associated conditions such as elevated intraocular pressure in the eyes of humans.
Inventor(s): Chang; Chin-Ming (Tustin, CA), Beck; Gary J. (Fullerton, CA), Pratt; Cynthia C. (Mission Viejo, CA), Batoosingh; Amy L. (Mission Viejo, CA)
Assignee: Allergan, Inc. (Irvine, CA)
Application Number:11/844,476
Patent Claims: 1. A composition comprising 0.2% brimonidine (w/v) and 0.5% timolol (w/v), in a single composition.

2. The composition of claim 1 further comprising from 0.001% to 0.01% benzalkonium chloride.

3. The composition of claim 2 comprising about 0.005% benzalkonium chloride.

4. The composition of claim 1 wherein brimonidine is brimonidine tartrate and timolol is timolol maleate.

5. The composition of claim 1 which is useful for treating ocular hypertension.

6. The composition of claim 1 which is useful for treating glaucoma.

7. An article of manufacture comprising packaging material and a composition within said packaging material, wherein said composition comprises 0.2% brimonidine by weight and 0.5% timolol by weight, in a single composition, and wherein said packaging indicates that the composition is useful for treating glaucoma or ocular hypertension by twice a day topical administration of the composition to a person's eye.

8. The article of manufacture of claim 7 wherein the composition further comprises from 0.001% to 0.01% benzalkonium chloride.

9. The article of manufacture of claim 7 wherein the composition further comprises about 0.005% benzalkonium chloride.
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