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|Title:||Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl- ]amino] benzonitrile|
|Abstract:||The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino- ]benzonitrile and to processes for their preparation.|
|Inventor(s):||Guillemont; Jerome Emile Georges (Ande, FR), Stevens; Paul Theodoor Agnes (Turnhout, BE), Copmans; Alex Herman (Lille, BE), Peeters; Jozef (Beerse, BE), Stappers; Alfred Elisabeth (Oud-Turnhout, BE), Vandecruys; Roger Petrus Gerebern (Westerlo, BE), Stoffels; Paul (Hoogstraten, BE)|
|Assignee:||Janssen Pharmaceutica N.V. (Beerse, BE)|
|Patent Claims:||1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of formula (I-a) ##STR00004## wherein said pharmaceutically acceptable carrier comprises: from 0.01 to 5% of said pharmaceutical composition of a wetting agent; from 40 to 92% of said pharmaceutical composition of a diluent; from 0 to 10% of said pharmaceutical composition of a polymer; from 2 to 10% of said pharmaceutical composition of a disintegrant; from 0.1 to 5% of said pharmaceutical composition of a glidant; and from 0.1 to 1.5% of said pharmaceutical composition of a lubricant; and wherein said compound of formula (I-a) is present in said pharmaceutical composition at from 5-50% of said pharmaceutical composition.|
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