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|Title:||Anti-inflammatory androstane derivative|
|Abstract:||According to one aspect of the invention, there is provided a compound of formula (I) ##STR00001## and solvates thereof. There are also provided compositions containing the compound, processes for preparing it, and its use in therapy.|
|Inventor(s):||Biggadike; Keith (Stevenage, GB), Coote; Steven John (Stevenage, GB), Nice; Rosalyn Kay (Stevenage, GB)|
|Assignee:||Glaxo Group Limited (Greenford, Middlesex, GB)|
1. A pharmaceutical composition comprising dry powder particles which are between 1 and 10 microns in size and which comprise the compound of formula (I) ##STR00026## in the form of
an unsolvated Form 1 polymorph, characterized by an XRPD profile having a peak at around 18.9 degrees 2 Theta, wherein said compound of formula (I) is present in the amount of 0.001 to 10% by weight of said pharmaceutical composition.
2. The pharmaceutical composition of claim 1, further comprising lactose.
3. A dry powder inhaler comprising a pharmaceutical composition comprising the compound of formula (I) ##STR00027## in the form of an unsolvated Form 1 polymorph, characterized by an XRPD profile having a peak at around 18.9 degrees 2 Theta, wherein said compound of formula (I) is present in the amount of 0.001 to 10% by weight of said pharmaceutical composition.
4. The dry powder inhaler of claim 3 further comprising lactose.
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