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Claims for Patent: 7,621,891

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Claims for Patent: 7,621,891

Title:Method and apparatus for delivering epinephrine
Abstract:A method of administering liquid medicine such as epinephrine to a patient includes administering a first dose followed by administering an optional second dose is described herein. Also described herein are devices useful for carrying out the methods described and kits containing these devices.
Inventor(s): Wyrick; Ronald (Spokane, WA)
Assignee: Washington Biotech Corporation (Spokane, WA)
Application Number:11/276,460
Patent Claims: 1. A drug delivery device containing an epinephrine solution, wherein the device comprises: a tubular barrel having a muzzle end with a needle receiving aperture; a syringe subassembly receiving cavity situated along the barrel adjacent the muzzle end, adapted to releasably and slidably receive a syringe subassembly for movement toward and away from the muzzle end with a needle of the syringe subassembly being capable of projection through the needle receiving aperture; a syringe subassembly held within the syringe subassembly receiving cavity and movable therein; a syringe driver connected to the barrel, and having a driver bar movable toward the muzzle end against the syringe subassembly and into the syringe subassembly receiving cavity to move the syringe subassembly for administration of medicine therefrom; a penetration controller mounted at the muzzle end of the barrel and having a syringe subassembly abutment spaced from the muzzle end to achieve a desired needle penetration depth position; said penetration controller including a front spring that maintains the syringe subassembly in retracted position within the tubular barrel such that the needle of the syringe subassembly is within the barrel unless the syringe driver is activated to extend the needle of the syringe subassembly projecting it through the needle receiving aperture; a detachable nose cap at the muzzle end of the barrel, which allows a user to gain access to the syringe subassembly for administration of a second or subsequent dose if needed by a user, wherein said detachable nose cap and penetration controller with front spring are connected to form a cap and penetration control assembly, which can be removed by release of the detachable nose cap; the penetration controller having at least one control sleeve connected with the nose cap and having at least said front spring therebetween; a first dose of about 0.3 mL or about 0.15 mL of the epinephrine solution that is injectable by automatic injection and a second dose of about 0.3 mL or about 0.15 mL of the epinephrine solution that is injectable by manual injection, wherein the total amount of the epinephrine delivered between the first and second doses is 0.3 mg or 0.6 mg.

2. The drug delivery device of claim 1, wherein the concentration of the first dose is about 0.5 mg of epinephrine per mL of epinephrine solution or about 1.0 mg of epinephrine per mL of epinephrine solution and the concentration of the second dose is about 0.5 mg epinephrine per mL of epinephrine solution or about 1.0 mg of epinephrine per mL of epinephrine solution.

3. The drug delivery device of claim 1, wherein the device comprises a first dose of about 0.3 mL of the epinephrine solution by automatic injection and means for delivering a second dose of about 0.3 mL of the epinephrine solution by manual injection.

4. The drug delivery device of claim 1, wherein the device comprises a first dose of about 0.15 mL of the epinephrine solution by automatic injection and means for delivering a second dose of about 0.15 mL of the epinephrine solution by manual injection.

5. A drug delivery device containing an epinephrine solution, wherein the device comprises: a tubular barrel having a muzzle end with a needle receiving aperture; a syringe subassembly receiving cavity situated along the barrel adjacent the muzzle end, adapted to releasably and slidably receive a syringe subassembly for movement toward and away from the muzzle end with a needle of the syringe subassembly being capable of projection through the needle receiving aperture; a syringe subassembly held within the syringe subassembly receiving cavity and movable therein; a syringe driver connected to the barrel, and having a driver bar movable toward the muzzle end against the syringe subassembly and into the syringe subassembly receiving cavity to move the syringe subassembly for administration of medicine therefrom; a penetration controller mounted at the muzzle end of the barrel and having a syringe subassembly abutment spaced from the muzzle end to achieve a desired needle penetration depth position; said penetration controller including a front spring that maintains the syringe subassembly in retracted position within the tubular barrel such that the needle of the syringe subassembly is within the barrel unless the syringe driver is activated to extend the needle of the syringe subassembly projecting it through the needle receiving aperture; a detachable nose cap at the muzzle end of the barrel, which allows a user to gain access to the syringe subassembly for administration of a second or subsequent dose if needed by a user, wherein said detachable nose cap and penetration controller with front spring are connected to form a cap and penetration control assembly, which can be removed by release of the detachable nose cap; the penetration controller having a control sleeve with features to help maintain connection therebetween, the features selected from the group consisting of, the control sleeve connected to the nose cap with at least portions of the front spring therebetween, the control sleeve having a flange with at least one lobe which engages with features of the nose cap, the control sleeve having a flange with lobes which engage with thread features of the nose cap, the control sleeve having a flange and a spring with at least one enlarged end winding that is positioned between the flange and the nose cap, the control sleeve having at least one lobe that engages in the nose cap; a first dose of about 0.3 mL or about 0.15 mL of the epinephrine solution that is injectable by automatic injection and a second dose of about 0.3 mL or about 0.15 mL of the epinephrine solution that is injectable by manual injection, wherein the total amount of the epinephrine delivered between the first and second doses is 0.3 mg or 0.6 mg.

6. The drug delivery device of claim 5, wherein the concentration of the first dose is about 0.5 mg of epinephrine per mL of epinephrine solution or about 1.0 mg of epinephrine per mL of epinephrine solution and the concentration of the second dose is about 0.5 mg epinephrine per mL of epinephrine solution or about 1.0 mg of epinephrine per mL of epinephrine solution.

7. The drug delivery device of claim 5, wherein the device comprises a first dose of about 0.3 mL of the epinephrine solution by automatic injection and means for delivering a second dose of about 0.3 mL of the epinephrine solution by manual injection.

8. The drug delivery device of claim 5, wherein the device comprises a first dose of about 0.15 mL of the epinephrine solution by automatic injection and means for delivering a second dose of about 0.15 mL of the epinephrine solution by manual injection.

9. A drug delivery device containing an epinephrine solution, wherein the device comprises: a tubular barrel having a muzzle end with a needle receiving aperture; a syringe subassembly receiving cavity situated along the barrel adjacent the muzzle end, adapted to releasably and slidably receive a syringe subassembly for movement toward and away from the muzzle end with a needle of the syringe subassembly being capable of projection through the needle receiving aperture; a syringe subassembly held within the syringe subassembly receiving cavity and movable therein; a syringe driver connected to the barrel, and having a driver bar movable toward the muzzle end against the syringe subassembly and into the syringe subassembly receiving cavity to move the syringe subassembly for administration of medicine therefrom; a penetration controller mounted at the muzzle end of the barrel and having a syringe subassembly abutment spaced from the muzzle end to achieve a desired needle penetration depth position; said penetration controller including a front spring that maintains the syringe subassembly in retracted position within the tubular barrel such that the needle of the syringe subassembly is within the barrel unless the syringe driver is activated to extend the needle of the syringe subassembly projecting it through the needle receiving aperture; a detachable nose cap at the muzzle end of the barrel, which allows a user to gain access to the syringe subassembly for administration of a second or subsequent dose if needed by a user, wherein said detachable nose cap and penetration controller with front spring are connected to form a cap and penetration control assembly, which can be removed by release of the detachable nose cap; the penetration controller having a control sleeve with at least one flange which engage with features of the nose cap to help maintain connection therebetween; a first dose of about 0.3 mL or about 0.15 mL of the epinephrine solution that is injectable by automatic injection and a second dose of about 0.3 mL or about 0.15 mL of the epinephrine solution that is injectable by manual injection, wherein the total amount of the epinephrine delivered between the first and second doses is 0.3 mg or 0.6 mg.

10. The drug delivery device of claim 9, wherein the concentration of the first dose is about 0.5 mg of epinephrine per mL of epinephrine solution or about 1.0 mg of epinephrine per mL of epinephrine solution and the concentration of the second dose is about 0.5 mg epinephrine per mL of epinephrine solution or about 1.0 mg of epinephrine per mL of epinephrine solution.

11. The drug delivery device of claim 9, wherein the device comprises a first dose of about 0.3 mL of the epinephrine solution by automatic injection and means for delivering a second dose of about 0.3 mL of the epinephrine solution by manual injection.

12. The drug delivery device of claim 9, wherein the device comprises a first dose of about 0.15 mL of the epinephrine solution by automatic injection and means for delivering a second dose of about 0.15 mL of the epinephrine solution by manual injection.
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