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Claims for Patent: 7,619,001

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Claims for Patent: 7,619,001

Title:Utilization of dialkylfumarates
Abstract: The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.
Inventor(s): Joshi; Rajendra Kumar (Zurich, CH), Strebel; Hans-Peter (Muri, CH)
Assignee: Biogen IDEC International GmbH (Zug, CH)
Application Number:11/765,578
Patent Claims: 1. A method of treating multiple sclerosis comprising administering, to a patient in need of treatment for multiple sclerosis, an amount of a pharmaceutical preparation effective for treating multiple sclerosis, the pharmaceutical preparation comprising at least one excipient or at least one carrier or at least one combination thereof; and dimethyl fumarate, methyl hydrogen fumarate, or a combination thereof.

2. The method of claim 1, wherein the dimethyl fumarate, methyl hydrogen fumarate, or a combination thereof is present in an amount of from 10 to 300 mg in the pharmaceutical preparation.

3. The method of claim 1, wherein the dimethyl fumarate, methyl hydrogen fumarate, or a combination thereof is provided in one or more capsules.

4. The method of claim 1, the pharmaceutical preparation comprising a combination of dimethyl fumarate and methyl hydrogen fumarate.

5. The method of claim 1, the pharmaceutical preparation comprising methyl hydrogen fumarate.

6. The method of claim 1, the pharmaceutical preparation comprising dimethyl fumarate.

7. The method of claim 6, wherein at least 50 mg of dimethyl fumarate is present in the pharmaceutical preparation.

8. The method of claim 6, wherein at least 110 mg of dimethyl fumarate is present in the pharmaceutical preparation.

9. The method of claim 6, wherein at least 120 mg of dimethyl fumarate is present in the pharmaceutical preparation.

10. The method of claim 6, wherein 50 mg of dimethyl fumarate is present in the pharmaceutical preparation.

11. The method of claim 6, wherein 110 mg of dimethyl fumarate is present in the pharmaceutical preparation.

12. The method of claim 6, wherein 120 mg of dimethyl fumarate is present in the pharmaceutical preparation.

13. The method of claim 1, wherein the pharmaceutical preparation is formulated for oral administration.

14. The method of claim 1, wherein the pharmaceutical preparation is formulated as a solid dosage form.

15. The method of claim 1, wherein the pharmaceutical preparation is formulated as microtablets.

16. The method of claim 15, wherein the microtablets are provided in one or more capsules, wherein at least 50 mg of dimethyl fumarate is present in each capsule.

17. The method of claim 16, wherein at least 110 mg of dimethyl fumarate is present in each capsule.

18. The method of claim 17, wherein at least 120 mg of dimethyl fumarate is present in each capsule.

19. The method of claim 15, wherein the microtablets are enteric-coated.

20. The method of claim 19, wherein the microtablets have a mean diameter in the range of 0.3 mm to 2.0 mm, exclusive of any coating on the microtablets.

21. The method of claim 20, wherein the microtablets have a mean diameter of 2.0 mm, exclusive of any coating on the microtablets.

22. The method of claim 1, the pharmaceutical preparation comprising at least one carrier.

23. The method of claim 1, the pharmaceutical preparation comprising at least one excipient.

24. The method of claim 1, the pharmaceutical preparation comprising at least one excipient and at least one carrier.
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