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Claims for Patent: 7,592,339

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Claims for Patent: 7,592,339

Title:Substituted oxazolidinones and their use in the field of blood coagulation
Abstract: The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) ##STR00001## processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
Inventor(s): Straub; Alexander (Wuppertal, DE), Lampe; Thomas (Wuppertal, DE), Pohlmann; Jens (Wuppertal, DE), Rohrig; Susanne (Essen, DE), Perzborn; Elisabeth (Wuppertal, DE), Schlemmer; Karl-Heinz (Wuppertal, DE), Pernerstorfer; Joseph (Wuppertal, DE)
Assignee: Bayer Schering Pharma Aktiengesellschaft (Berlin, DE)
Application Number:11/460,529
Patent Claims: 1. A method for inhibiting thrombus formation comprising administering an effective amount of a compound of formula: ##STR00173## or a hydrate thereof, to a patient in need of said method.

2. A method of claim 1, wherein said patient has a thromboembolism.

3. A method of claim 2 wherein said thromboembolism is a venous thromboembolism.

4. A method of claim 3 wherein said venous thromboembolism comprises pulmonary embolism.

5. A method of claim 3 wherein said venous thromboembolism comprises deep vein thrombosis.

6. A method for preventing thromboembolism comprising administering an effective amount of a compound of formula: ##STR00174## or a hydrate thereof, to a patient in need of said method, wherein the compound is present in an amount effective to inhibit thrombus formation.

7. A method of claim 6, wherein said method prevents venous thromboembolism.

8. A method of claim 7, wherein said method prevents pulmonary embolism.

9. A method of claim 7, wherein said method prevents deep vein thrombosis.

10. A method for preventing a disorder due to thrombus formation selected from the group consisting of myocardial infarct, unstable angina, stroke, transitory ischaemic attacks, peripheral arterial occlusive disorders, pulmonary embolisms and deep venous thromboses comprising administering an effective amount of a compound of formula: ##STR00175## or a hydrate thereof, to a patient in need of said method, wherein the compound is present in an amount effective to inhibit thrombus formation.

11. A method of claim 10, wherein said disorder is stroke.

12. A method of claim 10, wherein said disorder is myocardial infarct.

13. A method of claim 10, wherein said disorder is unstable angina.

14. A method of claim 10, wherein said disorder is peripheral arterial occlusive disorder.

15. A method of claim 10, wherein said disorder is pulmonary embolism.

16. A method of claim 10, wherein said disorder is deep venous thrombosis.

17. A method for treating a disorder selected from the group consisting of myocardial infarct, unstable angina, stroke, transitory ischaemic attacks, peripheral arterial occlusive disorders, pulmonary embolisms and deep venous thromboses comprising administering an effective amount of a compound of formula: ##STR00176## or a hydrate thereof, to a patient in need of said method.

18. A method of claim 17 wherein said method treats pulmonary embolism.

19. A method of claim 17 wherein said method treats deep vein thrombosis.

20. A method of claim 17 wherein said method treats myocardial infarct.

21. A method of claim 17 wherein said method treats stroke.
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