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Serving 500+ biopharmaceutical companies globally:

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Generated: July 26, 2017

DrugPatentWatch Database Preview

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Title:Rasagiline formulations and processes for their preparation
Abstract:The subject invention provides a pharmaceutical composition comprising N-propargyl-1(R)-aminoindan mesylate; a pharmaceutically acceptable carrier; and greater than 0.7 ppm but less than 30 ppm in total of a compound having the structure: ##STR00001## and any salts of the compound.
Inventor(s): Sterling; Jeffrey (Jerusalem, IL), Lerner; David (Jerusalem, IL), Rosen; Harel (Ra'anana, IL), Bronov; Leonid (Netanya, IL), Medini-Green; Dalia (Pardes Hanna, IL), Iosefzon; Berta (Jerusalem, IL), Berger-Peskin; Tirtsah (Ra'anana, IL), Lidor-Hadas; Ramy (Kfar Saba, IL), Bahar; Eliezer (Tel Aviv, IL)
Assignee: Teva Pharmaceutical Industries, Ltd. (Petach-Tikva, IL)
Application Number:11/634,916
Patent Claims: 1. A pharmaceutical composition comprising N-propargyl-1(R)-aminoindan mesylate; a pharmaceutically acceptable carrier; and greater than 0.7 ppm but less than 30 ppm in total of a compound having the structure: ##STR00033## and any salts of the compound, wherein the compound is formed by chlorination of N-propargyl-1(R)-aminoindan in N-propargyl-1(R)-aminoindan mesylate.

2. The pharmaceutical composition of claim 1, comprising greater than 2 ppm in total of the compound and salts of the compound.

3. The pharmaceutical composition of claim 1, comprising greater than 4 ppm in total of the compound and salts of the compound.

4. The pharmaceutical composition of claim 1, comprising greater than 7 ppm of the compound and salts of the compound.

5. The pharmaceutical composition of claim 1, wherein the pharmaceutically acceptable carrier does not include magnesium stearate.

6. The pharmaceutical composition of claim 1, wherein the pharmaceutically acceptable carrier is mannitol, starch, pregelatinized starch, colloidal silicon dioxide, stearic acid or talc.

7. The pharmaceutical composition of claim 1, wherein the pharmaceutically acceptable carrier is mannitol, starch, pregelatinized starch, colloidal silicon dioxide, stearic acid, and talc.

8. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition does not include maltodextrin, croscarmellose sodium, citric acid, lactose, glyceryl behenate, and hydrogenated vegetable oil type I.

9. The pharmaceutical composition of claim 1, comprising less than 20 ppm in total of the compound and salts of the compound.

10. The pharmaceutical composition of any one of claims 2-4 or 9, wherein the pharmaceutically acceptable carrier is mannitol, starch, pregelatinized starch, colloidal silicon dioxide, stearic acid or talc.

11. The pharmaceutical composition of any one of claims 2-4 or 9, comprising mannitol, starch, pregelatinized starch, colloidal silicon dioxide, stearic acid and talc.

12. The pharmaceutical composition of any one of claims 2-4 or 9, wherein the pharmaceutical composition does not include maltodextrin, croscarmellose sodium, citric acid, lactose, glyceryl behenate, and hydrogenated vegetable oil type I.
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Serving 500+ biopharmaceutical companies globally:

Chubb
Federal Trade Commission
Merck
Fish and Richardson
Express Scripts
Fuji
Baxter
Dow
Citi
Julphar

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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