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Last Updated: November 26, 2020

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Claims for Patent: 7,560,120

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Summary for Patent: 7,560,120
Title:Vehicles for delivery of biologically active substances
Abstract: A formulation containing one or more biologically active substances dissolved, dispersed, emulsified, or suspended within a vehicle of one or more citric acid esters and/or citric acid ethers. Methods for making and using are disclosed, as are kits for administration of the pharmaceutical formulation.
Inventor(s): Shukla; Atul J. (Cordova, TN), Johnson; James R. (Germantown, TN), Sun; Yichun (Germantown, TN), Cooper; Robert (Starkville, MS), Boring; Gregg (Starkville, MS), Scruggs; Dan (Starkville, MS)
Assignee: University of Tennessee Research Foundation (Knoxville, TN)
Application Number:11/194,885
Patent Claims: 1. A composition comprising a biologically active substance (BAS) and a citric acid ester (CAE) and/or a citric acid ether, wherein the amount of the CAE and/or the ether in the composition is sufficient to dissolve, disperse, emulsify, or suspend the entire amount of the BAS in the composition, and the BAS in the composition is dissolved, dispersed, emulsified, or suspended in the citric acid ester or ether wherein the CAE and/or the citric acid ether is present in the composition in a concentration higher than that of any other constituent of the composition.

2. The composition of claim 1 wherein the CAE is selected from the group consisting of triethyl citrate, acetyl triethyl citrate, tri-n-butyl citrate, acetyl tri-n-butyl citrate, acetyl tri-n-hexyl citrate, and butyryl tri-n-hexyl citrate.

3. The composition of claim 1 wherein the composition comprises a multiplicity of different CAEs and/or citric acid ethers.

4. The composition of claim 1 which frrther contains a polymer,

5. The composition of claim 1 wherein the concentration of the CAE and the citric acid ether in the composition is greater than 3% w/w.

6. The composition of claim 5 wherein the concentration of the CAE and the citric acid ether in the composition is greater than 10% w/w.

7. The composition of claim 6 wherein the concentration of the CAE and the citric acid ether in the composition is greater than 25% w/w.

8. The composition of claim 7 wherein the concentration of the CAE and the citric acid ether in the composition is greater than 50% w/w.

9. The composition of claim 1 which further contains a gelling agent

10. The composition of claim 1 which is a liquid.

11. The composition of claim 1 which is a semi-solid, a gel, a paste, or a solid.

12. The composition of claim 1 wherein the CAE or citric acid ether is hydrophobic.

13. The composition of claim 1 wherein the CAE or citric acid ether is hydrophilic.

14. The composition of claim 1 which further comprises a wax.

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