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Serving hundreds of leading biopharmaceutical companies globally:

Harvard Business School
Boehringer Ingelheim
Chinese Patent Office
Johnson and Johnson
Farmers Insurance

Generated: May 23, 2018

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Claims for Patent: 7,553,479

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Summary for Patent: 7,553,479
Title:Heat stable colloidal iron oxides coated with reduced carbohydrates and uses thereof
Abstract:Compositions, methods of making the compositions, and methods of using the compositions are provided for an enhanced magnetic resonance imaging agent and a hematinic agent, the agents comprising carboxyalkylated reduced polysaccharides coated ultrasmall superparamagnetic iron oxides. Methods of use of the carboxymethyl reduced dextran as a plasma extender are provided.
Inventor(s): Groman; Ernest V. (Brookline, MA), Paul; Kenneth G. (Holliston, MA), Frigo; Timothy B. (Waltham, MA), Bengele; Howard (Canton, MA), Lewis; Jerome M. (Newton, MA)
Assignee: AMAG Pharmaceuticals, Inc. (Cambridge, MA)
Application Number:10/386,394
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 7,553,479
Patent Claims: 1. A pharmaceutical composition in a vial comprising an injectable reduced carboxymethylated dextran iron oxide complex, wherein the carboxymethylated reduced dextran comprises at least 750 micromole and less than 1500 micromole of carboxyl groups per gram of dextran and wherein said complex is stable at a temperature of at least about 100.degree. C.

2. A pharmaceutical composition in a vial according to claim 1, wherein the injectable complex is terminally sterilizable within the vial at a temperature of about 121.degree. C.

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Serving hundreds of leading biopharmaceutical companies globally:

US Army
Argus Health
Fish and Richardson

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