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Claims for Patent: 7,544,364

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Claims for Patent: 7,544,364

Title:Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
Abstract:Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.
Inventor(s): Judice; J. Kevin (El Granada, CA), Shaw; Jeng-Pyng (Saratoga, CA), Mu; YongQi (Los Altos, CA), Conner; Michael W. (Half Moon Bay, CA), Pace; John L. (San Anselmo, CA)
Assignee: Theravance, Inc. (South San Francisco, CA)
Application Number:11/410,597
Patent Claims: 1. A pharmaceutical composition comprising: (a) a cyclodextrin; and (b) a glycopeptide antibiotic or a pharmaceutically acceptable salt thereof; wherein the glycopeptide antibiotic has the formula: ##STR00008## Wherein R.sup.20 is a lipid substituent containing from 10 to 40 carbon atoms, and optionally containing heteroatoms selected from halo, oxygen, nitrogen, sulfur and phosphorous; and wherein R.sup.19 is hydrogen, and R.sup.5 is a substituent of the formula: --CH.sub.2--NH--R.sup.a--P(O)(OH).sub.2 wherein R.sup.a is alkylene.

2. The pharmaceutical composition of claim 1, wherein the cyclodextrin is hydroxypropyl-.beta.-cyclodextrin.

3. The pharmaceutical composition of claim 1, wherein the cyclodextrin is sulfobutyl ether .beta.-cyclodextrin.

4. The pharmaceutical composition of claim 1, wherein the composition is a lyophilized powder.

5. The pharmaceutical composition of claim 1, wherein the cyclodextrin comprises about 1 to 40 weight percent of the composition.

6. The pharmaceutical composition of claim 1, wherein the glycopeptide antibiotic is in the form of a pharmaceutically acceptable salt.

7. The pharmaceutical composition of claim 1, wherein the glycopeptide antibiotic is in the form of a hydrochloride salt.
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