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Serving hundreds of leading biopharmaceutical companies globally:

Merck
Moodys
Cantor Fitzgerald
Dow
Express Scripts
Harvard Business School
US Department of Justice
Chinese Patent Office
Mallinckrodt

Generated: April 24, 2018

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Claims for Patent: 7,541,350

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Summary for Patent: 7,541,350
Title:Formulation containing anti-inflammatory androstane derivative
Abstract:There is provided a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) ##STR00001## or a solvate thereof.
Inventor(s): Biggadike; Keith (Stevenage, GB), Sayani; Amyn Pyarali (Mississauga, CA), Buxton; Ian Richard (Mississauga, CA), Reed; Kenton Lewis (Mississauga, CA)
Assignee: Glaxo Group Limited (Greenford, Middlesex, GB)
Application Number:10/918,779
Patent Claims: 1. A pharmaceutical formulation comprising an aqueous suspension of particulate unsolvated polymorph Form 1 of compound of formula (I) ##STR00008## one or more suspending agents, one or more preservatives, one or more wetting agents, and one or more isotonicity adjusting agents.

2. The pharmaceutical formulation of claim 1, wherein the compound of formula (I) is present within the formulation in an amount between 0.005% and 1% (w/w), based on the total weight of the formulation.

3. A pharmaceutical formulation according to claim 2 wherein the suspending agent is one or more of microcrystalline cellulose and carboxy methylcellulose sodium, the preservative is one or more of EDTA and benzalkonium chloride, the wetting agent is one or more of polyoxyethylene (20) sorbitan monooleate and the isotonicity adjusting agent is dextrose.

4. A method of treating rhinitis comprising the nasal application of a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) ##STR00009## or a solvate thereof, one or more suspending agents one or more preservatives one or more wetting agents, and one or more isotonicity adjusting agents.

5. A method of claim 4, wherein the compound of formula (I) is used as unsolvated polymorph Form 1.

6. A method of claim 5, wherein the compound of formula (I) is present within the formulation in an amount between 0.005% and 1% (w/w), based on the total weight of the formulation.

7. The method of claim 5, wherein the suspending agent is one or more of microcrystalline cellulose and carboxy methylcellulose sodium, the preservative is one or more of EDTA and benzalkonium chloride, the wetting agent is one or more of polyoxyethylene (20) sorbitan monooleate and the isotonicity adjusting agent is dextrose.

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Serving hundreds of leading biopharmaceutical companies globally:

Fuji
Fish and Richardson
Cipla
Colorcon
Moodys
Deloitte
QuintilesIMS
Farmers Insurance
Accenture

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