Claims for Patent: 7,538,211

Summary for Patent: 7,538,211

Title:	Aptamer therapeutics useful in the treatment of complement-related disorders
Abstract:	The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
Inventor(s):	Claude Benedict, John Diener, David Epstein, Dilara Grate, Sara Chesworth Keene, Jeffrey Kurz, Markus Kurz, Thomas Greene McCauley, James Rottman, Kristin Thompson, Charles Wilson, Anna J. Zoltoski
Assignee:	Astellas US LLC, Archemix LLC
Application Number:	US11/318,227
Patent Claims:	1. An aptamer comprising: wherein fC and fU=2′-fluoro nucleotides, mG and mA=2′-OMe nucleotides, all other nucleotides are 2′-OH, and 3T indicates an inverted thymidine cap. 2. The aptamer of claim 1, wherein the linker is an alkyl linker. 3. The aptamer of claim 2, wherein the alkyl linker comprises 2 to 18 consecutive CH2 groups. 4. The aptamer of claim 3, wherein the alkyl linker comprises 2 to 12 consecutive CH2 groups. 5. The aptamer of claim 4, wherein the alkyl linker comprises 3 to 6 consecutive CH2 groups. 6. The aptamer of claim 2, wherein the alkyl linker comprises 6 consecutive CH2 groups. 7. An aptamer comprising: wherein fC and fU=2′-fluoro nucleotides, and mG and mA=2′-OMe nucleotides and all other nucleotides are 2′-OH and 3T indicates an inverted deoxy thymidine.