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Generated: August 17, 2017

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Title:Cyclosporin galenic forms
Abstract: Pharmaceutical compositions comprising a cyclosporin as active ingredient, a fatty acid triglyceride, a glycerol fatty acid partial ester or propylene glycol or sorbitol complete or partial ester, preferably, and a tenside having an HLB of at least 10.
Inventor(s): Cavanak; Thomas (Biel-Benken, CH), Posanski; Ulrich (Freiburg, DE)
Assignee: Novartis AG (Basel, CH)
Application Number:11/453,504
Patent Claims: 1. A pharmaceutical composition for oral administration comprising: a) a cyclosporin as active ingredient in a carrier medium consisting of b) a fatty acid triglyceride and c) a glycerol fatty acid partial ester or propylene glycol or sorbitol complete or partial ester.

2. A pharmaceutical composition for oral administration comprising: a) a cyclosporin as active ingredient in a carrier medium consisting of b) a fatty acid triglyceride c) a glycerol fatty acid partial ester or propylene glycol or sorbitol complete or partial ester, and e') a tenside having an HLB of at least 10.

3. A pharmaceutical composition comprising: a) a cyclosporin as active ingredient in a carrier medium consisting essentially of b) a fatty acid triglyceride c) a glycerol fatty acid partial ester or propylene glycol or sorbitol complete or partial ester, and e') a tenside having an HLB of at least 10 wherein components (b) and (c) consist or consist essentially of the individual components of a trans-esterification product of a hydrogenated vegetable oil with glycerol, said composition: i) comprising Ciclosporin or [Nva].sup.2-Ciclosporine as component a): or ii) comprising components (a) and (e') in a ratio of 1: at least 1 p.p.w.

4. Composition according to claim 2, wherein (a) is present in an amount of from about 2 to about 20% by weight based on the total weight of components (a) to (c) and (e') inclusive.

5. Composition according to claim 2, wherein (e') comprises the reaction product of a natural or hydrogenated castor oil and ethylene oxide, a polyoxyethylene-sorbitan-fatty acid ester, a polyoxyethylene fatty acid ester, a polyoxyethylene-polyoxypropylene co-polymer or block co-polymer, dioctylsuccinate, di-[2-ethylhexyl]-succinate, a phospholipid, a propylene glycol mono- or di-fatty acid ester or sodium lauryl sulfate.

6. Composition according to claim 2 wherein (a) and (e') are present in a ratio of about 1:1 to 25 p.p.w. [(a):(e)].

7. Composition according to claim 2 comprising a component (a) and a component (e') as defined in claim 2 and [(b)+(c)] a transesterification product of a vegetable oil and glycerol, propylene glycol or sorbitol.

8. Composition according to claim 7 wherein (b) and (c) consist or consist essentially of the individual components (b) and (c) of a component [(b)+(c)] as defined in claim 7.

9. Composition according to claim 8 wherein (a) and [(b)+(c)] are present in a ratio of about 1:0.75 to 35 p.p.w. [(a):[(b)+(c)]].

10. Composition according to claim 2 wherein (b) and (c) are present in a ratio of about 1:0.02 to 3.0 p.p.w. [(b):c)].
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McKinsey
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Medtronic
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Citi
Chubb

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