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Last Updated: April 16, 2026

Claims for Patent: 7,494,982

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Summary for Patent: 7,494,982

Title:	Modified oligonucleotides for telomerase inhibition
Abstract:	Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
Inventor(s):	Sergei Gryaznov, Krisztina Pongracz
Assignee:	Geron Corp
Application Number:	US10/938,184
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 7,494,982
Patent Claims:	1. A compound having the structure: wherein “nps” represents a thiophosphoramidate linkage —NH—P(═O)(SH)—O—, connecting the 3'-carbon of one nucleoside to the 5'-carbon of the adjacent nucleoside; or a pharmaceutically acceptable salt thereof. 2. A pharmaceutical composition comprising a compound according to claim 1 formulated in a pharmaceutically acceptable excipient.

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