You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 28, 2024

Claims for Patent: 7,459,554


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 7,459,554
Title:Imidazopyrazine tyrosine kinase inhibitors
Abstract: Compounds of the formula ##STR00001## and pharmaceutically acceptable salts thereof, wherein Q.sup.1 and R.sup.1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.
Inventor(s): Dong; Han-Qing (Syosset, NY), Foreman; Kenneth (Syosset, NY), Mulvihill; Mark Joseph (East Northport, NY), Nigro; Anthony Innocenzo (Westwood, NJ), Steinig; Arno G. (East Northport, NY), Werner; Douglas (Holtsville, NY), Wilkes; Robin (Oxfordshire, GB)
Assignee: OSI Pharmaceuticals, Inc. (Melville, NY)
Application Number:10/965,182
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 7,459,554
Patent Claims: 1. A compound represented by Formula I: ##STR00446## or a pharmaceutically acceptable salt thereof, wherein: Q.sup.1 is aryl.sup.1, heteroaryl.sup.1, cycloalkyl, heterocyclyl, cycloalkenyl, or heterocycloalkenyl, any of which is optionally substituted by one to five independent G.sup.1 substituents; R.sup.1 is alkyl, cycloalkyl, bicycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclyl, or heterobicycloalkyl, any of which is optionally substituted by one or more independent G.sup.11 substituents; G.sup.1 and G.sup.41 are each independently halo, oxo, --CF.sub.3, --OCF.sub.3, --OR.sup.2, --NR.sup.2R.sup.3(R.sup.3a).sub.j1, --C(O)R.sup.2, --CO.sub.2R.sup.2, --CONR.sup.2R.sup.3, --NO.sub.2, --CN, --S(O).sub.j1R.sup.2, --SO.sub.2NR.sup.2R.sup.3, NR.sup.2(C.dbd.O)R.sup.3, NR.sup.2(C.dbd.O)OR.sup.3, NR.sup.2(C.dbd.O)NR.sup.2R.sup.3, NR.sup.2S(O).sub.j1R.sup.3, --(C.dbd.S)OR.sup.2, --(C.dbd.O)SR.sup.2, --NR.sup.2(C.dbd.NR.sup.3)NR.sup.2aR.sup.3a, --NR.sup.2(C.dbd.NR.sup.3)OR.sup.2a, --NR.sup.2(C.dbd.NR.sup.3)SR.sup.3a, --O(C.dbd.O)OR.sup.2, --O(C.dbd.O)NR.sup.2R.sup.3, --O(C.dbd.O)SR.sup.2, --S(C.dbd.O)OR.sup.2, --S(C.dbd.O)NR.sup.2R.sup.3, C.sub.0-10alkyl, C.sub.2-10alkenyl, C.sub.2-10alkynyl, C.sub.1-10alkoxyC.sub.1-10alkyl, C.sub.1-10alkoxyC.sub.2-10alkenyl, C.sub.1-10alkoxyC.sub.2-10alkynyl, C.sub.1-10alkylthioC.sub.1-10alkyl, C.sub.1-10alkylthioC.sub.2-10alkenyl, C.sub.1-10alkylthioC.sub.2-10alkynyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, cycloC.sub.3-8alkylC.sub.1-10alkyl, cycloC.sub.3-8alkenylC.sub.1-10alkyl, cycloC.sub.3-8alkylC.sub.2-10alkenyl, cycloC.sub.3-8alkenylC.sub.2-10alkenyl, cycloC.sub.3-8alkylC.sub.2-10alkynyl, cycloC.sub.3-8alkenylC.sub.2-10alkynyl, heterocyclyl-C.sub.0-10alkyl, heterocyclyl-C.sub.2-10alkenyl, or heterocyclyl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, oxo, --CF.sub.3, --OCF.sub.3, --OR.sup.222, --NR.sup.222R.sup.333(R.sup.333a).sub.j1a, --C(O)R.sup.222, --CO.sub.2R.sup.222, --CONR.sup.222R.sup.333, --NO.sub.2, --CN, --S(O).sub.j1aR.sup.222, --SO.sub.2NR.sup.222R.sup.333, NR.sup.222(C.dbd.O)R.sup.333, NR.sup.222(C.dbd.O)OR.sup.333, NR.sup.222(C.dbd.O)NR.sup.222R.sup.333, NR.sup.222S(O).sub.j1aR.sup.333, --(C.dbd.S)OR.sup.222, --(C.dbd.O)SR.sup.222, --NR.sup.222(C.dbd.NR.sup.333)NR.sup.222aR.sup.333a, --NR.sup.222(C.dbd.NR.sup.333)OR.sup.222a, --NR.sup.222(C.dbd.NR.sup.333)SR.sup.333a, --O(C.dbd.O)OR.sup.222, --O(C.dbd.O)NR.sup.222R.sup.333, --O(C.dbd.O)SR.sup.222, --S(C.dbd.O)OR.sup.222, or --S(C.dbd.O)NR.sup.222R.sup.333 substituents; or --(X.sup.1).sub.n--(Y.sup.1).sub.m--R.sup.4; or aryl-C.sub.0-10alkyl, aryl-C.sub.2-10alkenyl, or aryl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, --CF.sub.3, --OCF.sub.3, --OR.sup.222, --NR.sup.222R.sup.333(R.sup.333a).sub.j2a, --C(O)R.sup.222, --CO.sub.2R.sup.222, --CONR.sup.222R.sup.333, --NO.sub.2, --CN, --S(O).sub.j2aR.sup.222, --SO.sub.2NR.sup.222R.sup.333, NR.sup.222(C.dbd.O)R.sup.333, NR.sup.222(C.dbd.O)OR.sup.333, NR.sup.222(C.dbd.O)NR.sup.222R.sup.333, NR.sup.222S(O).sub.j2aR.sup.333, --(C.dbd.S)OR.sup.222, --(C.dbd.O)SR.sup.222, --NR.sup.222(C.dbd.NR.sup.333)NR.sup.222aR.sup.333a, --NR.sup.222(C.dbd.NR.sup.333)OR.sup.222a, --NR.sup.222(C.dbd.NR.sup.333)SR.sup.333a, --O(C.dbd.O)OR.sup.222, --O(C.dbd.O)NR.sup.222R.sup.333, --O(C.dbd.O)SR.sup.222, --S(C.dbd.O)OR.sup.222, or --S(C.dbd.O)NR.sup.222R.sup.333 substituents; or hetaryl-C.sub.0-10alkyl, hetaryl-C.sub.2-10alkenyl, or hetaryl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, --CF.sub.3, --OCF.sub.3, --OR.sup.222, --NR.sup.222R.sup.333(R.sup.333a).sub.j3a, --C(O)R.sup.222, --CO.sub.2R.sup.222, --CONR.sup.222R.sup.333, --NO.sub.2, --CN, --S(O).sub.j3aR.sup.222, --SO.sub.2NR.sup.222R.sup.333, NR.sup.222(C.dbd.O)R.sup.333, NR.sup.222(C.dbd.O)OR.sup.333, NR.sup.222(C.dbd.O)NR.sup.222R.sup.333, NR.sup.222S(O).sub.j3aR.sup.333, --(C.dbd.S)OR.sup.222, --(C.dbd.O)SR.sup.222, --NR.sup.222(C.dbd.NR.sup.333)NR.sup.222aR.sup.333a, --NR.sup.222(C.dbd.NR.sup.333)OR.sup.222a, --NR.sup.222(C.dbd.NR.sup.333)SR.sup.333a, --O(C.dbd.O)OR.sup.222, --O(C.dbd.O)NR.sup.222R.sup.333, --O(C.dbd.O)SR.sup.222, --S(C.dbd.O)OR.sup.222, or --S(C.dbd.O)NR.sup.222R.sup.333 substituents; G.sup.11 is halo, oxo, --CF.sub.3, --OCF.sub.3, --OR.sup.21, --NR.sup.21R.sup.31(R.sup.3a1).sub.j4, --C(O)R.sup.21, --CO.sub.2R.sup.21, --CONR.sup.21R.sup.31, --NO.sub.2, --CN, --S(O).sub.j4R.sup.21, --SO.sub.2NR.sup.21R.sup.31, NR.sup.21(C.dbd.O)R.sup.31, NR.sup.21(C.dbd.O)OR.sup.31, NR.sup.21(C.dbd.O)NR.sup.21R.sup.31, NR.sup.21S(O).sub.j4R.sup.31, --(C.dbd.S)OR.sup.21, --(C.dbd.O)SR.sup.21, --NR.sup.21 (C.dbd.NR.sup.31)NR.sup.2a1R.sup.3a1, --NR.sup.21(C.dbd.NR.sup.31)OR.sup.2a1, --NR.sup.21(C.dbd.NR.sup.31)SR.sup.3a1, --O(C.dbd.O)OR.sup.21, --O(C.dbd.O)NR.sup.21R.sup.31, --O(C.dbd.O)SR.sup.21, --S(C.dbd.O)OR.sup.21, --S(C.dbd.O)NR.sup.21R.sup.31, --P(O)OR.sup.21OR.sup.31, C.sub.0-10alkyl, C.sub.2-10alkenyl, C.sub.2-10alkynyl, C.sub.1-10alkoxyC.sub.1-10alkyl, C.sub.1-10alkoxyC.sub.2-10alkenyl, C.sub.1-10alkoxyC.sub.2-10alkynyl, C.sub.1-10alkylthioC.sub.1-10alkyl, C.sub.1-10alkylthioC.sub.2-10alkenyl, C.sub.1-10alkylthioC.sub.2-10alkynyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, cycloC.sub.3-8alkylC.sub.1-10alkyl, cycloC.sub.3-8alkenylC.sub.1-10alkyl, cycloC.sub.3-8alkylC.sub.2-10alkenyl, cycloC.sub.3-8alkenylC.sub.2-10alkenyl, cycloC.sub.3-8alkylC.sub.2-10alkynyl, cycloC.sub.3-8alkenylC.sub.2-10alkynyl, heterocyclyl-C.sub.0-10alkyl, heterocyclyl-C.sub.2-10alkenyl, or heterocyclyl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, oxo, --CF.sub.3, --OCF.sub.3, --OR.sup.2221, --NR.sup.2221R.sup.3331(R.sup.333a1).sub.j4a, --C(O)R.sup.2221, --CO.sub.2R.sup.2221, --CONR.sup.2221R.sup.3331, --NO.sub.2, --CN, --S(O).sub.j4aR.sup.2221, --SO.sub.2NR.sup.2221R.sup.3331, NR.sup.2221(C.dbd.O)R.sup.3331, NR.sup.2221(C.dbd.O)OR.sup.3331, NR.sup.2221(C.dbd.O)NR.sup.2221R.sup.3331, NR.sup.2221S(O).sub.j4aR.sup.3331, --(C.dbd.S)OR.sup.2221, --(C.dbd.O)SR.sup.2221, --NR.sup.2221(C.dbd.NR.sup.3331)NR.sup.222a1R.sup.333a1, --NR.sup.2221(C.dbd.NR.sup.3331)OR.sup.222a1, --NR.sup.2221(C.dbd.NR.sup.3331)SR.sup.333a1, --O(C.dbd.O)OR.sup.2221, --O(C.dbd.O)NR.sup.2221R.sup.3331, --O(C.dbd.O)SR.sup.2221, --S(C.dbd.O)OR.sup.2221, --P(O)OR.sup.2221OR.sup.3331, or --S(C.dbd.O)NR.sup.2221R.sup.3331 substituents; or aryl-C.sub.0-10alkyl, aryl-C.sub.2-10alkenyl, or aryl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, --CF.sub.3, --OCF.sub.3, --OR.sup.2221, --NR.sup.2221R.sup.3331(R.sup.333a1).sub.j5a, --C(O)R.sup.2221, --CO.sub.2R.sup.2221, --CONR.sup.2221R.sup.3331, --NO.sub.2, --CN, --S(O).sub.j5aR.sup.2221, --SO.sub.2NR.sup.2221R.sup.3331, NR.sup.2221(C.dbd.O)R.sup.3331, NR.sup.2221(C.dbd.O)OR.sup.3331, NR.sup.2221(C.dbd.O)NR.sup.2221R.sup.3331, NR.sup.2221S(O).sub.j5aR.sup.3331, --(C.dbd.S)OR.sup.2221, --(C.dbd.O)SR.sup.2221, --NR.sup.2221(C.dbd.NR.sup.3331)NR.sup.222a1R.sup.333a1, --NR.sup.2221(C.dbd.NR.sup.3331)OR.sup.222a1, --NR.sup.2221(C.dbd.NR.sup.3331)SR.sup.333a1, --O(C.dbd.O)OR.sup.2221, --O(C.dbd.O)NR.sup.2221R.sup.3331, --O(C.dbd.O)SR.sup.2221, --S(C.dbd.O)OR.sup.2221, --P(O)OR.sup.2221R.sup.3331, or --S(C.dbd.O)NR.sup.2221R.sup.3331 substituents; or hetaryl-C.sub.0-10alkyl, hetaryl-C.sub.2-10alkenyl, or hetaryl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, --CF.sub.3, --OCF.sub.3, --OR.sup.2221, --NR.sup.2221R.sup.3331(R.sup.333a1).sub.j6a, --C(O)R.sup.2221, --CO.sub.2R.sup.2221, --CONR.sup.2221R.sup.3331, --NO.sub.2, --CN, --S(O).sub.j6aR.sup.2221, --SO.sub.2NR.sup.2221R.sup.3331, NR.sup.2221(C.dbd.O)R.sup.3331, NR.sup.2221(C.dbd.O)OR.sup.3331, NR.sup.2221(C.dbd.O)NR.sup.2221R.sup.3331, NR.sup.2221S(O).sub.j6aR.sup.3331, --(C.dbd.S)OR.sup.2221, --(C.dbd.O)SR.sup.2221, --NR.sup.2221(C.dbd.NR.sup.3331)NR.sup.222a1R.sup.333a1, --NR.sup.2221(C.dbd.NR.sup.3331)OR.sup.222a1, --NR.sup.2221(C.dbd.NR.sup.3331)SR.sup.333a1, --O(C.dbd.O)OR.sup.2221, --O(C.dbd.O)NR.sup.2221R.sup.3331, --O(C.dbd.O)SR.sup.2221, --S(C.dbd.O)OR.sup.2221, --P(O)OR.sup.2221OR.sup.3331, or --S(C.dbd.O)NR.sup.2221R.sup.3331 substituents; or G.sup.11 is taken together with the carbon to which it is attached to form a double bond which is substituted with R.sup.5 and G.sup.111; R.sup.2, R.sup.2a, R.sup.3, R.sup.3a, R.sup.222, R.sup.222a, R.sup.333, R.sup.333a, R.sup.21, R.sup.2a1, R.sup.31, R.sup.3a1, R.sup.2221, R.sup.222a1, R.sup.3331, and R.sup.333a1 are each independently equal to C.sub.0-10alkyl, C.sub.2-10alkenyl, C.sub.2-10alkynyl, C.sub.1-10alkoxyC.sub.1-10alkyl, C.sub.1-10alkoxyC.sub.2-10alkenyl, C.sub.1-10alkoxyC.sub.2-10alkynyl, C.sub.1-10alkylthioC.sub.1-10alkyl, C.sub.1-10alkylthioC.sub.2-10alkenyl, C.sub.1-10alkylthioC.sub.2-10alkynyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, cycloC.sub.3-8alkylC.sub.1-10alkyl, cycloC.sub.3-8alkenylC.sub.1-10alkyl, cycloC.sub.3-8alkylC.sub.2-10alkenyl, cycloC.sub.3-8alkenylC.sub.2-10alkenyl, cycloC.sub.3-8alkylC.sub.2-10alkynyl, cycloC.sub.3-8alkenylC.sub.2-10alkynyl, heterocyclyl-C.sub.0-10alkyl, heterocyclyl-C.sub.2-10alkenyl, or heterocyclyl-C.sub.2-10alkynyl, any of which is optionally substituted by one or more G.sup.111 substituents; or aryl-C.sub.0-10alkyl, aryl-C.sub.2-10alkenyl, or aryl-C.sub.2-10alkynyl, hetaryl-C.sub.0-10alkyl, hetaryl-C.sub.2-10alkenyl, or hetaryl-C.sub.2-10alkynyl, any of which is optionally substituted by one or more G.sup.111 substituents; or in the case of --NR.sup.2R.sup.3(R.sup.3a).sub.j1 or --NR.sup.222R.sup.333(R.sup.333a).sub.j1a or --NR.sup.222R.sup.333(R.sup.333a).sub.j2a or --NR.sup.2221R.sup.3331(R.sup.333a1).sub.j3a or --NR.sup.2221R.sup.3331(R.sup.333a1).sub.j4a or --NR.sup.2221R.sup.3331(R.sup.333a1).sub.j5a or --NR.sup.2221R.sup.3331(R.sup.333a1).sub.j6a, R.sup.2 and R.sup.3 or R.sup.222 and R.sup.3333 or R.sup.2221 and R.sup.3331 taken together with the nitrogen atom to which they are attached form a 3-10 membered saturated ring, unsaturated ring, heterocyclic saturated ring, or heterocyclic unsaturated ring, wherein said ring is optionally substituted by one or more G.sup.111 substituents; X.sup.1 and Y.sup.1 are each independently --O--, --NR.sup.7--, --S(O).sub.j7--, --CR.sup.5R.sup.6--, --N(C(O)OR.sup.7)--, --N(C(O)R.sup.7)--, --N(SO.sub.2R.sup.7)--, --CH.sub.2O--, --CH.sub.2S--, --CH.sub.2N(R.sup.7)--, --CH(NR.sup.7)--, --CH.sub.2N(C(O)R.sup.7)--, --CH.sub.2N(C(O)OR.sup.7)--, --CH.sub.2N(SO.sub.2R.sup.7)--, --CH(NHR.sup.7)--, --CH(NHC(O)R.sup.7)--, --CH(NHSO.sub.2R.sup.7)--, --CH(NHC(O)OR.sup.7)--, --CH(OC(O)R.sup.7)--, --CH(OC(O)NHR.sup.7)--, --CH.dbd.CH--, --C.ident.C--, --C(.dbd.NOR.sup.7)--, --C(O)--, --CH(OR.sup.7)--, --C(O)N(R.sup.7)--, --N(R.sup.7)C(O)--, --N(R.sup.7)S(O)--, --N(R.sup.7)S(O).sub.2-- --OC(O)N(R.sup.7)--, --N(R.sup.7)C(O)N(R.sup.7)--, --NR.sup.7C(O)O--, --S(O)N(R.sup.7)--, --S(O).sub.2N(R.sup.7)--, --N(C(O)R.sup.7)S(O)--, --N(C(O)R.sup.7)S(O).sub.2--, --N(R.sup.7)S(O)N(R.sup.7)--, --N(R.sup.7)S(O).sub.2N(R.sup.7)--, --C(O)N(R.sup.7)C(O)--, --S(O)N(R.sup.7)C(O)--, --S(O).sub.2N(R.sup.7)C(O)--, --OS(O)N(R.sup.7)--, --OS(O).sub.2N(R.sup.7)--, --N(R.sup.7)S(O)O--, --N(R.sup.7)S(O).sub.2O--, --N(R.sup.7)S(O)C(O)--, --N(R.sup.7)S(O).sub.2C(O)--, --SON(C(O)R.sup.7)--, --SO.sub.2N(C(O)R.sup.7)--, --N(R.sup.7)SON(R.sup.7)--, --N(R.sup.7)SO.sub.2N(R.sup.7)--, --C(O)O--, --N(R.sup.7)P(OR.sup.8)O--, --N(R.sup.7)P(OR.sup.8)--, --N(R.sup.7)P(O)(OR.sup.8)O--, --N(R.sup.7)P(O)(OR.sup.8)--, --N(C(O)R.sup.7)P(OR.sup.8)O--, --N(C(O)R.sup.7)P(OR.sup.8)--, --N(C(O)R.sup.7)P(O)(OR.sup.8)O--, --N(C(O)R.sup.7)P(OR.sup.8)--, --CH(R.sup.7)S(O)--, --CH(R.sup.7)S(O).sub.2--, --CH(R.sup.7)N(C(O)OR.sup.7)--, --CH(R.sup.7)N(C(O)R.sup.7)--, --CH(R.sup.7)N(SO.sub.2R.sup.7)--, --CH(R.sup.7)O--, --CH(R.sup.7)S--, --CH(R.sup.7)N(R.sup.7)--, --CH(R.sup.7)N(C(O)R.sup.7)--, --CH(R.sup.7)N(C(O)OR.sup.7)--, --CH(R.sup.7)N(SO.sub.2R.sup.7)--, --CH(R.sup.7)C(.dbd.NOR.sup.7)--, --CH(R.sup.7)C(O)--, --CH(R.sup.7)CH(OR.sup.7)--, --CH(R.sup.7)C(O)N(R.sup.7)--, --CH(R.sup.7)N(R.sup.7)C(O)--, --CH(R.sup.7)N(R.sup.7)S(O)--, --CH(R.sup.7)N(R.sup.7)S(O).sub.2--, --CH(R.sup.7)OC(O)N(R.sup.7)--, --CH(R.sup.7)N(R.sup.7)C(O)N(R.sup.7)--, --CH(R.sup.7)NR.sup.7C(O)O--, --CH(R.sup.7)S(O)N(R.sup.7)--, --CH(R.sup.7)S(O).sub.2N(R.sup.7)--, --CH(R.sup.7)N(C(O)R.sup.7)S(O)--, --CH(R.sup.7)N(C(O)R.sup.7)S(O)--, --CH(R.sup.7)N(R.sup.7)S(O)N(R.sup.7)--, --CH(R.sup.7)N(R.sup.7)S(O).sub.2N(R.sup.7)--, --CH(R.sup.7)C(O)N(R.sup.7)C(O)--, --CH(R.sup.7)S(O)N(R.sup.7)C(O)--, --CH(R.sup.7)S(O).sub.2N(R.sup.7)C(O)--, --CH(R.sup.7)OS(O)N(R.sup.7)--, --CH(R.sup.7)OS(O).sub.2N(R.sup.7)--, --CH(R.sup.7)N(R.sup.7)S(O)O--, --CH(R.sup.7)N(R.sup.7)S(O).sub.2O--, --CH(R.sup.7)N(R.sup.7)S(O)C(O)--, --CH(R.sup.7)N(R.sup.7)S(O).sub.2C(O)--, --CH(R.sup.7)SON(C(O)R.sup.7)--, --CH(R.sup.7)SO.sub.2N(C(O)R.sup.7)--, --CH(R.sup.7)N(R.sup.7)SON(R.sup.7)--, --CH(R.sup.7)N(R.sup.7)SO.sub.2N(R.sup.7)--, --CH(R.sup.7)C(O)O--, --CH(R.sup.7)N(R.sup.7)P(OR.sup.8)O--, --CH(R.sup.7)N(R.sup.7)P(OR.sup.8)--, --CH(R.sup.7)N(R.sup.7)P(O)(OR.sup.8)O--, --CH(R.sup.7)N(R.sup.7)P(O)(OR.sup.8)--, --CH(R.sup.7)N(C(O)R.sup.7)P(OR.sup.8)O--, --CH(R.sup.7)N(C(O)R.sup.7)P(OR.sup.8)--, --CH(R.sup.7)N(C(O)R.sup.7)P(O)(OR.sup.8)O--, or --CH(R.sup.7)N(C(O)R.sup.7)P(OR.sup.8)--; or X.sup.1 and Y.sup.1 are each independently represented by one of the following structural formulas: ##STR00447## R.sup.10, taken together with the phosphinamide or phosphonamide, is a 5-, 6-, or 7-membered aryl, heteroaryl or heterocyclyl ring system; R.sup.5, R.sup.6, and G.sup.111 are each independently a C.sub.0-10alkyl, C.sub.2-10alkenyl, C.sub.2-10alkynyl, C.sub.1-10alkoxyC.sub.1-10alkyl, C.sub.1-10alkoxyC.sub.2-10alkenyl, C.sub.1-10alkoxyC.sub.2-10alkynyl, C.sub.1-10alkylthioC.sub.1-10alkyl, C.sub.1-10alkylthioC.sub.2-10alkenyl, C.sub.1-10alkylthioC.sub.2-10alkynyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, cycloC.sub.3-8alkylC.sub.1-10alkyl, cycloC.sub.3-8alkenylC.sub.1-10alkyl, cycloC.sub.3-8alkylC.sub.2-10alkenyl, cycloC.sub.3-8alkenylC.sub.2-10alkenyl, cycloC.sub.3-8alkylC.sub.2-10alkynyl, cycloC.sub.3-8alkenylC.sub.2-10alkynyl, heterocyclyl-C.sub.0-10alkyl, heterocyclyl-C.sub.2-10alkenyl, or heterocyclyl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, --CF.sub.3, --OCF.sub.3, --OR.sup.77, --NR.sup.77R.sup.87, --C(O)R.sup.77, --CO.sub.2R.sup.77, --CONR.sup.77R.sup.87, --NO.sub.2, --CN, --S(O).sub.j5aR.sup.77, --SO.sub.2NR.sup.77R.sup.87, NR.sup.77(C.dbd.O)R.sup.87, NR.sup.77(C.dbd.O)OR.sup.87, NR.sup.77(C.dbd.O)NR.sup.78R.sup.87, NR.sup.77S(O).sub.j5aR.sup.87,

--(C.dbd.S)OR.sup.77, --(C.dbd.O)SR.sup.77, --NR.sup.77(C.dbd.NR.sup.87)NR.sup.78R.sup.88, --NR.sup.77(C.dbd.NR.sup.87)OR.sup.78, --NR.sup.77(C.dbd.NR.sup.87)SR.sup.78, --O(C.dbd.O)OR.sup.77, --O(C.dbd.O)NR.sup.77R.sup.87, --O(C.dbd.O)SR.sup.77, --S(C.dbd.O)OR.sup.77, --P(O)OR.sup.77OR.sup.87, or --S(C.dbd.O)NR.sup.77R.sup.87 substituents; or aryl-C.sub.0-10alkyl, aryl-C.sub.2-10alkenyl, or aryl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, --CF.sub.3, --OCF.sub.3, --OR.sup.77, --NR.sup.77R.sup.87, --C(O)R.sup.77, --CO.sub.2R.sup.77, --CONR.sup.77R.sup.87, --NO.sub.2, --CN, --S(O).sub.j5aR.sup.77, --SO.sub.2NR.sup.77R.sup.87, NR.sup.77(C.dbd.O)R.sup.87, NR.sup.77(C.dbd.O)OR.sup.87, NR.sup.77(C.dbd.O)NR.sup.78R.sup.87, NR.sup.77S(O).sub.j5aR.sup.87, --(C.dbd.S)OR.sup.77, --(C.dbd.O)SR.sup.77, --NR.sup.77(C.dbd.NR.sup.87)NR.sup.78R.sup.88, --NR.sup.77(C.dbd.NR.sup.87)OR.sup.78, --NR.sup.77(C.dbd.NR.sup.87)SR.sup.78, --O(C.dbd.O)OR.sup.77, --O(C.dbd.O)NR.sup.77R.sup.87, --O(C.dbd.O)SR.sup.77, --S(C.dbd.O)OR.sup.77, --P(O)OR.sup.77R.sup.87, or --S(C.dbd.O)NR.sup.77R.sup.87 substituents; or hetaryl-C.sub.0-10alkyl, hetaryl-C.sub.2-10alkenyl, or hetaryl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, --CF.sub.3, --OCF.sub.3, --OR.sup.77, --NR.sup.77R.sup.87, --C(O)R.sup.77, --CO.sub.2R.sup.77, --CONR.sup.77R.sup.87, --NO.sub.2, --CN, --S(O).sub.j5aR.sup.77, --SO.sub.2NR.sup.77R.sup.87, NR.sup.77(C.dbd.O)R.sup.87, NR.sup.77(C.dbd.O)OR.sup.87, NR.sup.77(C.dbd.O)NR.sup.78R.sup.87, NR.sup.77S(O).sub.j5aR.sup.87, --(C.dbd.S)OR.sup.77, --(C.dbd.O)SR.sup.77, --NR.sup.77(C.dbd.NR.sup.87)NR.sup.78R.sup.88, --NR.sup.77(C.dbd.NR.sup.87)OR.sup.78, --NR.sup.77(C.dbd.NR.sup.87)SR.sup.78, --O(C.dbd.O)OR.sup.77, --O(C.dbd.O)NR.sup.77R.sup.87, --O(C.dbd.O)SR.sup.77, --S(C.dbd.O)OR.sup.77, --P(O)OR.sup.77OR.sup.87, or --S(C.dbd.O)NR.sup.77R.sup.87 substituents; or R.sup.5 with R.sup.6 taken together with the respective carbon atom to which they are attached, form a 3-10 membered saturated or unsaturated ring, wherein said ring is optionally substituted with R.sup.69; or R.sup.5 with R.sup.6 taken together with the respective carbon atom to which they are attached, form a 3-10 membered saturated or unsaturated heterocyclic ring, wherein said ring is optionally substituted with R.sup.69; R.sup.7 and R.sup.8 are each independently H, acyl, alkyl, alkenyl, aryl, heteroaryl, heterocyclyl or cycloalkyl, any of which is optionally substituted by one or more G.sup.111 substituents; R.sup.4 is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, cycloalkenyl, or heterocycloalkenyl, any of which is optionally substituted by one or more G.sup.41 substituents; R.sup.69 is equal to halo, --OR.sup.78, --SH, --NR.sup.78R.sup.88, --CO.sub.2R.sup.78, --CONR.sup.78R.sup.88, --NO.sub.2, --CN, --S(O).sub.j8R.sup.78, --SO.sub.2NR.sup.78R.sup.88, C.sub.0-10alkyl, C.sub.2-10alkenyl, C.sub.2-10alkynyl, C.sub.1-10alkoxyC.sub.1-10alkyl, C.sub.1-10alkoxyC.sub.2-10alkenyl, C.sub.1-10alkoxyC.sub.2-10alkynyl, C.sub.1-10alkylthioC.sub.1-10alkyl, C.sub.1-10alkylthioC.sub.2-10alkenyl, C.sub.1-10alkylthioC.sub.2-10alkynyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, cycloC.sub.3-8alkylC.sub.1-10alkyl, cycloC.sub.3-8alkenylC.sub.1-10alkyl, cycloC.sub.3-8alkylC.sub.2-10alkenyl, cycloC.sub.3-8alkenylC.sub.2-10alkenyl, cycloC.sub.3-8alkylC.sub.2-10alkynyl, cycloC.sub.3-8alkenylC.sub.2-10alkynyl, heterocyclyl-C.sub.0-10alkyl, heterocyclyl-C.sub.2-10alkenyl, or heterocyclyl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, cyano, nitro, --OR.sup.778, --SO.sub.2NR.sup.778R.sup.888, or --NR.sup.778R.sup.888 substituents; or aryl-C.sub.0-10alkyl, aryl-C.sub.2-10alkenyl, or aryl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, cyano, nitro, --OR.sup.778, C.sub.1-10alkyl, C.sub.2-10alkenyl, C.sub.2-10alkynyl, haloC.sub.1-10alkyl, haloC.sub.2-10alkenyl, haloC.sub.2-10alkynyl, --COOH, C.sub.1-4alkoxycarbonyl, --CONR.sup.778R.sup.888, --SO.sub.2NR.sup.778R.sup.888, or --NR.sup.778R.sup.888 substituents; or hetaryl-C.sub.0-10alkyl, hetaryl-C.sub.2-10alkenyl, or hetaryl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, cyano, nitro, --OR.sup.778, C.sub.1-10alkyl, C.sub.2-10alkenyl, C.sub.2-10alkynyl, haloC.sub.1-10alkyl, haloC.sub.2-10alkenyl, haloC.sub.2-10alkynyl, --COOH, C.sub.1-4alkoxycarbonyl, --CONR.sup.778R.sup.888, --SO.sub.2NR.sup.778R.sup.888, or --NR.sup.778R.sup.888 substituents; or mono(C.sub.1-6alkyl)aminoC.sub.1-6alkyl, di(C.sub.1-6alkyl)aminoC.sub.1-6alkyl, mono(aryl)aminoC.sub.1-6alkyl, di(aryl)aminoC.sub.1-6alkyl, or --N(C.sub.1-6alkyl)-C.sub.1-6alkyl-aryl, any of which is optionally substituted with one or more independent halo, cyano, nitro, --OR.sup.778, C.sub.1-10alkyl, C.sub.2-10alkenyl, C.sub.2-10alkynyl, haloC.sub.1-10alkyl, haloC.sub.2-10alkenyl, haloC.sub.2-10alkynyl, --COOH, C.sub.1-4alkoxycarbonyl, --CONR.sup.778R.sup.888 SO.sub.2NR.sup.778R.sup.888, or --NR.sup.778R.sup.888 substituents; or in the case of --NR.sup.78R.sup.88, R.sup.78 and R.sup.88 taken together with the nitrogen atom to which they are attached form a 3-10 membered saturated ring, unsaturated ring, heterocyclic saturated ring, or heterocyclic unsaturated ring, wherein said ring is optionally substituted with one or more independent halo, cyano, hydroxy, nitro, C.sub.1-10alkoxy, --SO.sub.2NR.sup.778R.sup.888, or --NR.sup.778R.sup.888 substituents; R.sup.77, R.sup.78, R.sup.87, R.sup.88, R.sup.778, and R.sup.888 are each independently C.sub.0-10alkyl, C.sub.2-10alkenyl, C.sub.2-10alkynyl, C.sub.1-10alkoxyC.sub.1-10alkyl, C.sub.1-10alkoxyC.sub.2-10alkenyl, C.sub.1-10alkoxyC.sub.2-10alkynyl, C.sub.1-10alkylthioC.sub.1-10alkyl, C.sub.1-10alkylthioC.sub.2-10alkenyl, C.sub.1-10alkylthioC.sub.2-10alkynyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, cycloC.sub.3-8alkylC.sub.1-10alkyl, cycloC.sub.3-8alkenylC.sub.1-10alkyl, cycloC.sub.3-8alkylC.sub.2-10alkenyl, cycloC.sub.3-8alkenylC.sub.2-10alkenyl, cycloC.sub.3-8alkylC.sub.2-10alkynyl, cycloC.sub.3-8alkenylC.sub.2-10alkynyl, heterocyclyl-C.sub.0-10alkyl, heterocyclyl-C.sub.2-10alkenyl, heterocyclyl-C.sub.2-10alkynyl, C.sub.1-10alkylcarbonyl, C.sub.2-10alkenylcarbonyl, C.sub.2-10alkynylcarbonyl, C.sub.1-10alkoxycarbonyl, C.sub.1-10alkoxycarbonylC.sub.1-10alkyl, monoC.sub.1-6alkylaminocarbonyl, diC.sub.1-6alkylaminocarbonyl, mono(aryl)aminocarbonyl, di(aryl)aminocarbonyl, or C.sub.1-10alkyl(aryl)aminocarbonyl, any of which is optionally substituted with one or more independent halo, cyano, hydroxy, nitro, C.sub.1-10alkoxy, --SO.sub.2N(C.sub.0-4alkyl)(C.sub.0-4alkyl), or --N(C.sub.0-4alkyl)(C.sub.0-4alkyl) substituents; or aryl-C.sub.0-10alkyl, aryl-C.sub.2-10alkenyl, or aryl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, cyano, nitro, --O(C.sub.0-4alkyl), C.sub.1-10alkyl, C.sub.2-10alkenyl, C.sub.2-10alkynyl, haloC.sub.1-10alkyl, haloC.sub.2-10alkenyl, haloC.sub.2-10alkynyl, --COOH, C.sub.1-4alkoxycarbonyl, --CON(C.sub.0-4alkyl)(C.sub.0-10alkyl), --SO.sub.2N(C.sub.0-4alkyl)(C.sub.0-4alkyl), or --N(C.sub.0-4alkyl)(C.sub.0-4alkyl) substituents; or hetaryl-C.sub.0-10alkyl, hetaryl-C.sub.2-10alkenyl, or hetaryl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, cyano, nitro, --O(C.sub.0-4alkyl), C.sub.1-10alkyl, C.sub.2-10alkenyl, C.sub.2-10alkynyl, haloC.sub.1-10alkyl, haloC.sub.2-10alkenyl, haloC.sub.2-10alkynyl, --COOH, C.sub.1-4alkoxycarbonyl, --CON(C.sub.0-4alkyl)(C.sub.0-4alkyl), --SO.sub.2N(C.sub.0-4alkyl)(C.sub.0-4alkyl), or --N(C.sub.0-4alkyl)(C.sub.0-4alkyl) substituents; or mono(C.sub.1-6alkyl)aminoC.sub.1-6alkyl, di(C.sub.1-6alkyl)aminoC.sub.1-6alkyl, mono(aryl)aminoC.sub.1-6alkyl, di(aryl)aminoC.sub.1-6alkyl, or --N(C.sub.1-6alkyl)-C.sub.1-6alkyl-aryl, any of which is optionally substituted with one or more independent halo, cyano, nitro, --O(C.sub.0-4alkyl), C.sub.1-10alkyl, C.sub.2-10alkenyl, C.sub.2-10alkynyl, haloC.sub.1-10alkyl, haloC.sub.2-10alkenyl, haloC.sub.2-10alkynyl, --COOH, C.sub.1-4alkoxycarbonyl, --CON(C.sub.0-4alkyl)(C.sub.0-4alkyl), --SO.sub.2N(C.sub.0-4alkyl)(C.sub.0-4alkyl), or --N(C.sub.0-4alkyl)(C.sub.0-4alkyl) substituents; and n, m, j1, j1a, j2a, j3a, j4, j4a, j5a, j6a, j7, and j8 are each independently equal to 0, 1, or 2.

2. The compound or salt of claim 1, wherein Q.sup.1 is aryl.sup.1 or heteroaryl.sup.1, any of which is optionally substituted by one or more independent G.sup.1 substituents.

3. The compound or salt of claim 2, wherein Q.sup.1 is heteroaryl.sup.1, any of which is optionally substituted by one or more independent G.sup.1 substituents.

4. The compound or salt of claim 3, wherein Q.sup.1 is aryl.sup.1, any of which is optionally substituted by one or more independent G.sup.1 substituents.

5. The compound or salt of claim 1, wherein G.sup.1 is halo, --CF.sub.3, --OCF.sub.3, --OR.sup.2, --NR.sup.2R.sup.3, --C(O)R.sup.2, --CO.sub.2R.sup.2, --CONR.sup.2R.sup.3, --S(O).sub.j1R.sup.2, --SO.sub.2NR.sup.2R.sup.3, NR.sup.2(C.dbd.O)R.sup.3, NR.sup.2(C.dbd.O)OR.sup.3, NR.sup.2(C.dbd.O)NR.sup.2R.sup.3, NR.sup.2S(O).sub.j1R.sup.3, --O(C.dbd.O)OR.sup.2, --O(C.dbd.O)NR.sup.2R.sup.3, C.sub.0-10alkyl, C.sub.2-10alkenyl, C.sub.2-10alkynyl, C.sub.1-10alkoxyC.sub.1-10alkyl, C.sub.1-10alkoxyC.sub.2-10alkenyl, C.sub.1-10alkoxyC.sub.2-10alkynyl, C.sub.1-10alkylthioC.sub.1-10alkyl, C.sub.1-10alkylthioC.sub.2-10alkenyl, C.sub.1-10alkylthioC.sub.2-10alkynyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, cycloC.sub.3-8alkylC.sub.1-10alkyl, cycloC.sub.3-8alkenylC.sub.1-10alkyl, cycloC.sub.3-8alkylC.sub.2-10alkenyl, cycloC.sub.3-8alkenylC.sub.2-10alkenyl, cycloC.sub.3-8alkylC.sub.2-10alkynyl, cycloC.sub.3-8alkenylC.sub.2-10alkynyl, heterocyclyl-C.sub.0-10alkyl, heterocyclyl-C.sub.2-10alkenyl, or heterocyclyl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, oxo, --CF.sub.3, --OCF.sub.3, --OR.sup.222, --NR.sup.222R.sup.333(R.sup.333a).sub.j1a, --C(O)R.sup.222, --CO.sub.2R.sup.222, --CONR.sup.222R.sup.333, --NO.sub.2, --CN, --S(O).sub.j1aR.sup.222, --SO.sub.2NR.sup.222R.sup.333, NR.sup.222(C.dbd.O)R.sup.333, NR.sup.222(C.dbd.O)OR.sup.333, NR.sup.222(C.dbd.O)NR.sup.222R.sup.333, NR.sup.222S(O).sub.j1aR.sup.333, --(C.dbd.S)OR.sup.222, --(C.dbd.O)SR.sup.222, --NR.sup.222(C.dbd.NR.sup.333)NR.sup.222aR.sup.333a, --NR.sup.222(C.dbd.NR.sup.333)OR.sup.222a, --NR.sup.222(C.dbd.NR.sup.333)SR.sup.333a, --O(C.dbd.O)OR.sup.222, --O(C.dbd.O)NR.sup.222R.sup.333, --O(C.dbd.O)SR.sup.222, --S(C.dbd.O)OR.sup.222, or --S(C.dbd.O)NR.sup.222R.sup.333 substituents; or --(X.sup.1).sub.n--(Y.sup.1).sub.m--R.sup.4; or aryl-C.sub.0-10alkyl, aryl-C.sub.2-10alkenyl, or aryl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, --CF.sub.3, --OCF.sub.3, --OR.sup.222, --NR.sup.222R.sup.333(R.sup.333a).sub.j2a, --C(O)R.sup.222, --CO.sub.2R.sup.222, --CONR.sup.222R.sup.333, --NO.sub.2, --CN, --S(O).sub.j2aR.sup.222, --SO.sub.2NR.sup.222R.sup.333, NR.sup.222(C.dbd.O)R.sup.333, NR.sup.222(C.dbd.O)OR.sup.333, NR.sup.222(C.dbd.O)NR.sup.222R.sup.333, NR.sup.222S(O).sub.j2aR.sup.333, --(C.dbd.S)OR.sup.222, --(C.dbd.O)SR.sup.222, --NR.sup.222(C.dbd.NR.sup.333)NR.sup.222aR.sup.333a, --NR.sup.222(C.dbd.NR.sup.333)OR.sup.222a, --NR.sup.222(C.dbd.NR.sup.333)SR.sup.333a, --O(C.dbd.O)OR.sup.222, --O(C.dbd.O)NR.sup.222R.sup.333, --O(C.dbd.O)SR.sup.222, --S(C.dbd.O)OR.sup.222, or --S(C.dbd.O)NR.sup.222R.sup.333 substituents; or hetaryl-C.sub.0-10alkyl, hetaryl-C.sub.2-10alkenyl, or hetaryl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, --CF.sub.3, --OCF.sub.3, --OR.sup.222, --NR.sup.222R.sup.333(R.sup.333a).sub.j3a, --C(O)R.sup.222, --CO.sub.2R.sup.222, --CONR.sup.222R.sup.333, --NO.sub.2, --CN, --S(O).sub.j3aR.sup.222, --SO.sub.2NR.sup.222R.sup.333, NR.sup.222(C.dbd.O)R.sup.333, NR.sup.222 (C.dbd.O)OR.sup.333, NR.sup.222(C.dbd.O)NR.sup.222R.sup.333, NR.sup.222S(O).sub.j3aR.sup.333, --(C.dbd.S)OR.sup.222, --(C.dbd.O)SR.sup.222, --NR.sup.222(C.dbd.NR.sup.333)NR.sup.222aR.sup.333a, --NR.sup.222(C.dbd.NR.sup.333)OR.sup.222a, --NR.sup.222(C.dbd.NR.sup.333)SR.sup.333a, --O(C.dbd.O)OR.sup.222, --O(C.dbd.O)NR.sup.222R.sup.333, --O(C.dbd.O)SR.sup.222, --S(C.dbd.O)OR.sup.222, or --S(C.dbd.O)NR.sup.222R.sup.333 substituents.

6. The compound or salt of claim 1, wherein G.sup.1 is halo, --OR.sup.2, --NR.sup.2R.sup.3, --C(O)R.sup.2, --CO.sub.2R.sup.2, --CONR.sup.2R.sup.3, --SO.sub.2NR.sup.2R.sup.3, NR.sup.2(C.dbd.O)R.sup.3, NR.sup.2(C.dbd.O)OR.sup.3, NR.sup.2(C.dbd.O)NR.sup.2R.sup.3, NR.sup.2S(O).sub.j1R.sup.3, --O(C.dbd.O)OR.sup.2, --O(C.dbd.O)NR.sup.2R.sup.3, C.sub.0-10alkyl, C.sub.2-10alkenyl, C.sub.1-10alkoxyC.sub.1-10alkyl, C.sub.1-10alkoxyC.sub.2-10alkenyl, C.sub.1-10alkylthioC.sub.1-10alkyl, C.sub.1-10alkylthioC.sub.2-10alkenyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, cycloC.sub.3-8alkylC.sub.1-10alkyl, cycloC.sub.3-8alkenylC.sub.1-10alkyl, cycloC.sub.3-8alkylC.sub.2-10alkenyl, cycloC.sub.3-8alkenylC.sub.2-10alkenyl, or heterocyclyl-C.sub.0-10alkyl, or heterocyclyl-C.sub.2-10alkenyl, any of which is optionally substituted with one or more independent oxo, --CF.sub.3, --OCF.sub.3, --OR.sup.222, --NR.sup.222R.sup.333, --C(O)R.sup.222, --CO.sub.2R.sup.222, --CONR.sup.222R.sup.333, --SO.sub.2NR.sup.222R.sup.333, NR.sup.222(C.dbd.O)R.sup.333, NR.sup.222(C.dbd.O)OR.sup.333, NR.sup.222(C.dbd.O)NR.sup.222R.sup.333, NR.sup.22S(O).sub.j1aR.sup.333, --NR.sup.222(C.dbd.NR.sup.333)NR.sup.222aR.sup.333a, or --O(C.dbd.O)NR.sup.222R.sup.333 substituents; or --(X.sup.1).sub.n--(Y.sup.1).sub.m--R.sup.4; or aryl-C.sub.0-10alkyl optionally substituted with one or more independent halo, --CF.sub.3, --OCF.sub.3, --OR.sup.222, --NR.sup.222R.sup.333, --C(O)R.sup.222, --CO.sub.2R.sup.222, --CONR.sup.222R.sup.333, --SO.sub.2NR.sup.222R.sup.333, NR.sup.222(C.dbd.O)R.sup.333, NR.sup.222(C.dbd.O)OR.sup.333, NR.sup.222(C.dbd.O)NR.sup.222R.sup.333, NR.sup.222S(O).sub.j2aR.sup.333, --NR.sup.222(C.dbd.NR.sup.333)NR.sup.222aR.sup.333a, or --O(C.dbd.O)NR.sup.222R.sup.333 substituents; or hetaryl-C.sub.0-10alkyl, optionally substituted with one or more independent halo, --CF.sub.3, --OCF.sub.3, --OR.sup.222, --NR.sup.222R.sup.333, --C(O)R.sup.222, --CO.sub.2R.sup.222, --CONR.sup.222R.sup.333, --SO.sub.2NR.sup.222R.sup.333, NR.sup.222(C.dbd.O)R.sup.333, NR.sup.222(C.dbd.O)OR.sup.333, NR.sup.222(C.dbd.O)NR.sup.222R.sup.333, NR.sup.222S(O).sub.j3aR.sup.333, --NR.sup.222(C.dbd.NR.sup.333)NR.sup.222aR.sup.333a, or --O(C.dbd.O)NR.sup.222R.sup.333 substituents.

7. The compound or salt of claim 1, wherein G.sup.1 is halo, --OR.sup.2, --NR.sup.2R.sup.3, --C(O)R.sup.2, --CO.sub.2R.sup.2, --CONR.sup.2R.sup.3, --SO.sub.2NR.sup.2R.sup.3, NR.sup.2(C.dbd.O)R.sup.3, NR.sup.2(C.dbd.O)OR.sup.3, NR.sup.2(C.dbd.O)NR.sup.2R.sup.3, NR.sup.2S(O).sub.j1R.sup.3, --O(C.dbd.O)OR.sup.2, --O(C.dbd.O)NR.sup.2R.sup.3, C.sub.0-10alkyl, C.sub.2-10alkenyl, C.sub.1-10alkoxyC.sub.1-10alkyl, C.sub.1-10alkylthioC.sub.1-10alkyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, or heterocyclyl-C.sub.0-10alkyl, or heterocyclyl-C.sub.2-10alkenyl, any of which is optionally substituted with one or more independent oxo, --CF.sub.3, --OCF.sub.3, --OR.sup.222, --NR.sup.222R.sup.333, --C(O)R.sup.222, --CO.sub.2R.sup.222, --CONR.sup.222R.sup.333, --SO.sub.2NR.sup.222R.sup.333, NR.sup.222(C.dbd.O)R.sup.333, NR.sup.222(C.dbd.O)OR.sup.333, NR.sup.222(C.dbd.O)NR.sup.222R.sup.333, NR.sup.222S(O).sub.j1aR.sup.333, --NR.sup.222(C.dbd.NR.sup.333)NR.sup.222aR.sup.333a, or --O(C.dbd.O)NR.sup.222R.sup.333 substituents; or --(X.sup.1).sub.n--(Y.sup.1).sub.m--R.sup.4; or aryl-C.sub.0-10alkyl, optionally substituted with one or more independent halo, --CF.sub.3, --OCF.sub.3, --OR.sup.222, --NR.sup.222R.sup.333, --C(O)R.sup.222, --CO.sub.2R.sup.222, --CONR.sup.222R.sup.333, --SO.sub.2NR.sup.222R.sup.333, NR.sup.222(C.dbd.O)R.sup.333, NR.sup.222(C.dbd.O)OR.sup.333, NR.sup.222(C.dbd.O)NR.sup.222R.sup.333, NR.sup.222S(O).sub.j2aR.sup.333, --NR.sup.222(C.dbd.NR.sup.333)NR.sup.222aR.sub.333a, or --O(C.dbd.O)NR.sup.222R.sup.333 substituents; or hetaryl-C.sub.0-10alkyl, optionally substituted with one or more independent halo, --CF.sub.3, --OCF.sub.3, --OR.sup.222, --NR.sup.222R.sup.333, --C(O)R.sup.222, --CO.sub.2R.sup.222, --CONR.sup.222R.sup.333, --SO.sub.2NR.sup.222R.sup.333, NR.sup.222(C.dbd.O)R.sup.333, NR.sup.222(C.dbd.O)OR.sup.333, NR.sup.222(C.dbd.O)NR.sup.222R.sup.333, NR.sup.222S(O).sub.j3aR.sup.333, --NR.sup.222(C.dbd.NR.sup.333)NR.sup.222aR.sup.333a, or --O(C.dbd.O)NR.sup.222R.sup.333 substituents.

8. The compound or salt of claim 1, wherein G.sup.1 is halo, --OR.sup.2, --NR.sup.2R.sup.3, --C(O)R.sup.2, --CO.sub.2R.sup.2, --CONR.sup.2R.sup.3, --SO.sub.2NR.sup.2R.sup.3, NR.sup.2(C.dbd.O)R.sup.3, NR.sup.2(C.dbd.O)OR.sup.3, NR.sup.2(C.dbd.O)NR.sup.2R.sup.3, NR.sup.2S(O).sub.j1R.sup.3, --O(C.dbd.O)OR.sup.2, --O(C.dbd.O)NR.sup.2R.sup.3, C.sub.0-10alkyl, C.sub.2-10alkenyl, C.sub.1-10alkoxyC.sub.1-10alkyl, C.sub.1-10alkylthioC.sub.1-10alkyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, or heterocyclyl-C.sub.0-10alkyl, or heterocyclyl-C.sub.2-10alkenyl, any of which is optionally substituted with one or more independent oxo, --CF.sub.3, --OCF.sub.3, --OR.sup.222, --NR.sup.222R.sup.333, --C(O)R.sup.222, --CO.sub.2R.sup.222, --CONR.sup.222R.sup.333, --SO.sub.2 NR.sup.222R.sup.333, NR.sup.222(C.dbd.O)R.sup.333, NR.sup.222(C.dbd.O)OR.sup.333, NR.sup.222(C.dbd.O)NR.sup.222R.sup.333, NR.sup.222S(O).sub.j1aR.sup.333, --NR.sup.222(C.dbd.NR.sup.333)NR.sup.222aR.sup.333a, or --O(C.dbd.O)NR.sup.222R.sup.333 substituents; or --(X.sup.1).sub.n--(Y.sup.1).sub.m--R.sup.4.

9. The compound or salt of claim 1, wherein X.sup.1 and Y.sup.1 are each independently --O--, --NR.sup.7--, --S(O).sub.j7--, --CR.sup.5R.sup.6--, --N(C(O)OR.sup.7)--, --N(C(O)R.sup.7)--, --N(SO.sub.2R.sup.7)--, --CH.sub.2O--, --CH.sub.2S--, --CH.sub.2N(R.sup.7)--, --CH(NR.sup.7)--, --CH.sub.2N(C(O)R.sup.7)--, --CH.sub.2N(C(O)OR.sup.7)--, --CH.sub.2N(SO.sub.2R.sup.7)--, --CH(NHR.sup.7)--, --CH(NHC(O)R.sup.7)--, --CH(NHSO.sub.2R.sup.7)--, --CH(NHC(O)OR.sup.7)--, --CH(OC(O)R.sup.7)--, --CH(OC(O)NHR.sup.7)--, --C(O)--, --CH(OR.sup.7)--, --C(O)N(R.sup.7)--, --N(R.sup.7)C(O)--, --N(R.sup.7)S(O)--, --N(R.sup.7)S(O).sub.2-- --OC(O)N(R.sup.7)--, --N(R.sup.7)C(O)N(R.sup.7)--, --NR.sup.7C(O)O--, --S(O)N(R.sup.7)--, --S(O).sub.2N(R.sup.7)--, --N(C(O)R.sup.7)S(O)--, --N(C(O)R.sup.7)S(O).sub.2--, --N(R.sup.7)S(O)N(R.sup.7)--, --N(R.sup.7)S(O).sub.2N(R.sup.7)--, --C(O)N(R.sup.7)C(O)--, --S(O)N(R.sup.7)C(O)--, --S(O).sub.2N(R.sup.7)C(O)--, --OS(O)N(R.sup.7)--, --OS(O).sub.2N(R.sup.7)--, --N(R.sup.7)S(O)O--, --N(R.sup.7)S(O).sub.2O--, --N(R.sup.7)S(O)C(O)--, --N(R.sup.7)S(O).sub.2C(O)--, --SON(C(O)R.sup.7)--, --SO.sub.2N(C(O)R.sup.7)--, --N(R.sup.7)SON(R.sup.7)--, --N(R.sup.7)SO.sub.2N(R.sup.7)--, --C(O)O--, --CH(R.sup.7)S(O)--, --CH(R.sup.7)S(O).sub.2--, --CH(R.sup.7)N(C(O)OR.sup.7)--, --CH(R.sup.7)N(C(O)R.sup.7)--, --CH(R.sup.7)N(SO.sub.2R.sup.7)--, --CH(R.sup.7)O--, --CH(R.sup.7)S--, --CH(R.sup.7)N(R.sup.7)--, --CH(R.sup.7)N(C(O)R.sup.7)--, --CH(R.sup.7)N(C(O)OR.sup.7)--, --CH(R.sup.7)N(SO.sub.2R.sup.7)--, --CH(R.sup.7)C(.dbd.NOR.sup.7)--, --CH(R.sup.7)C(O)--, --CH(R.sup.7)CH(OR.sup.7)--, --CH(R.sup.7)C(O)N(R.sup.7)--, --CH(R.sup.7)N(R.sup.7)C(O)--, --CH(R.sup.7)N(R.sup.7)S(O)--, --CH(R.sup.7)N(R.sup.7)S(O).sub.2--, --CH(R.sup.7)OC(O)N(R.sup.7)--, --CH(R.sup.7)N(R.sup.7)C(O)N(R.sup.7)--, --CH(R.sup.7)NR.sup.7C(O)O--, --CH(R.sup.7)S(O)N(R.sup.7)--, --CH(R.sup.7)S(O).sub.2N(R.sup.7)--, --CH(R.sup.7)N(C(O)R.sup.7)S(O)--, --CH(R.sup.7)N(C(O)R.sup.7)S(O)--, --CH(R.sup.7)N(R.sup.7)S(O)N(R.sup.7)--, --CH(R.sup.7)N(R.sup.7)S(O).sub.2N(R.sup.7)--, --CH(R.sup.7)C(O)N(R.sup.7)C(O)--, --CH(R.sup.7)S(O)N(R.sup.7)C(O)--, --CH(R.sup.7)S(O).sub.2N(R.sup.7)C(O)--, --CH(R.sup.7)OS(O)N(R.sup.7)--, --CH(R.sup.7)OS(O).sub.2N(R.sup.7)--, --CH(R.sup.7)N(R.sup.7)S(O)O--, --CH(R.sup.7)N(R.sup.7)S(O).sub.2O--, --CH(R.sup.7)N(R.sup.7)S(O)C(O)--, --CH(R.sup.7)N(R.sup.7)S(O).sub.2C(O)--, --CH(R.sup.7)SON(C(O)R.sup.7)--, --CH(R.sup.7)SO.sub.2N(C(O)R.sup.7)--, --CH(R.sup.7)N(R.sup.7)SON(R.sup.7)--, --CH(R.sup.7)N(R.sup.7)SO.sub.2N(R.sup.7)--, or --CH(R.sup.7)C(O)O--.

10. The compound or salt of claim 1 wherein Q.sup.1 is substituted by said one to five independent G.sup.1 substituents wherein at least one of said G.sup.1 substituents is --(X.sup.1).sub.n--(Y.sup.1).sub.m--R.sup.4, and wherein X.sup.1 and Y.sup.1 are each independently equal to --O--, --NR.sup.7--, --CR.sup.5R.sup.6--, --S(O).sub.j7--, or --C(O)--, and wherein n and m are both equal to 1 and j7 is equal to 1 or 2.

11. The compound or salt of claim 1 wherein Q.sup.1 is substituted by said one to five independent G.sup.1 substituents wherein at least one of said G.sup.1 substituents is --(X.sup.1).sub.n--(Y.sup.1).sub.m--R.sup.4, and wherein X.sup.1 and Y.sup.1 are each independently --O-- or --CR.sup.5R.sup.6--, and wherein n and m are equal to 1.

12. The compound or salt of claim 1 wherein R.sup.1 is cycloalkyl, bicycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclyl, or heterobicycloalkyl, any of which is optionally substituted by one or more independent G.sup.11 substituents.

13. The compound or salt of claim 1 wherein R.sup.1 is cycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, or heterocyclyl, any of which is optionally substituted by one or more independent G.sup.11 substituents.

14. The compound or salt of claim 1 wherein R.sup.1 is cycloalkyl or heterocyclyl, any of which is optionally substituted by one or more independent G.sup.11 substituents.

15. The compound or salt of claim 1 wherein R.sup.1 is cycloalkyl optionally substituted by one or more independent G.sup.11 substituents.

16. The compound or salt of claim 1 wherein R.sup.1 is heterocyclyl optionally substituted by one or more independent G.sup.11 substituents.

17. The compound or salt of claim 1 wherein R.sup.1 is aryl, heteroaryl, aralkyl, or heteroaralkyl, any of which is optionally substituted by one or more independent G.sup.11 substituents.

18. The compound or salt of claim 1 wherein R.sup.1 is aryl or heteroaryl, any of which is optionally substituted by one or more independent G.sup.11 substituents.

19. The compound or salt of claim 1 wherein G.sup.11 is --OR.sup.21, --NR.sup.21R.sup.31(R.sup.31a).sub.j4, --C(O)R.sup.21, --CO.sub.2R.sup.21, --CONR.sup.21R.sup.31, NR.sup.21(C.dbd.O)R.sup.31, NR.sup.21(C.dbd.O)OR.sup.31, NR.sup.21(C.dbd.O)NR.sup.21R.sup.31, NR.sup.21S(O).sub.j4R.sup.31, --O(C.dbd.O)OR.sup.21, --O(C.dbd.O)NR.sup.21R.sup.31, C.sub.0-10alkyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, heterocyclyl-C.sub.0-10alkyl, or heterocyclyl-C.sub.2-10alkenyl, any of which is optionally substituted with one or more independent halo, oxo, --CF.sub.3, --OCF.sub.3, --OR.sup.2221, --NR.sup.2221R.sup.3331(R.sup.333a).sub.j4a, --C(O)R.sup.2221, --CO.sub.2R.sup.2221, --CONR.sup.2221R.sup.3331, --NO.sub.2, --CN, --S(O).sub.j4aR.sup.2221, --SO.sub.2NR.sup.2221R.sup.3331, NR.sup.2221(C.dbd.O)R.sup.3331, NR.sup.2221(C.dbd.O)OR.sup.3331, NR.sup.2221(C.dbd.O)NR.sup.2221R.sup.3331, NR.sup.2221S(O).sub.j4aR.sup.3331, --(C.dbd.S)OR.sup.2221, --(C.dbd.O)SR.sup.2221, --NR.sup.2221(C.dbd.NR.sup.3331)NR.sup.222a1R.sup.333a1, --NR.sup.2221(C.dbd.NR.sup.3331)OR.sup.222a1, --NR.sup.2221(C.dbd.NR.sup.3331)SR.sup.333a1, --O(C.dbd.O)OR.sup.2221, --O(C.dbd.O)NR.sup.2221R.sup.3331, --O(C.dbd.O)SR.sup.2221, --S(C.dbd.O)OR.sup.2221, or --S(C.dbd.O)NR.sup.2221R.sup.3331 substituents; or aryl-C.sub.0-10alkyl, aryl-C.sub.2-10alkenyl, or aryl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, --CF.sub.3, --OCF.sub.3, --OR.sup.2221, --NR.sup.2221R.sup.3331(R.sup.333a1).sub.j5a, --C(O)R.sup.2221, --CO.sub.2R.sup.2221, --CONR.sup.2221R.sup.3331, --NO.sub.2, --CN, --S(O).sub.j5aR.sup.2221, --SO.sub.2NR.sup.2221R.sup.3331, NR.sup.2221(C.dbd.O)R.sup.3331, NR.sup.2221(C.dbd.O)OR.sup.3331, NR.sup.2221(C.dbd.O)NR.sup.2221R.sup.3331, NR.sup.2221S(O).sub.j5aR.sup.3331, --(C.dbd.S)OR.sup.2221, --(C.dbd.O)SR.sup.2221, --NR.sup.2221(C.dbd.NR.sup.3331)NR.sup.222a1R.sup.333a1, --NR.sup.2221(C.dbd.NR.sup.3331)OR.sup.222a1, --NR.sup.2221(C.dbd.NR.sup.3331)SR.sup.333a1, --O(C.dbd.O)OR.sup.2221, --O(C.dbd.O)NR.sup.2221R.sup.3331, --O(C.dbd.O)SR.sup.2221, --S(C.dbd.O)OR.sup.2221, or --S(C.dbd.O)NR.sup.2221R.sup.3331 substituents; or hetaryl-C.sub.0-10alkyl, hetaryl-C.sub.2-10alkenyl, or hetaryl-C.sub.2-10alkynyl, any of which is optionally substituted with one or more independent halo, --CF.sub.3, --OCF.sub.3, --OR.sup.2221, --NR.sup.2221R.sup.3331(R.sup.333a1).sub.j6a, --C(O)R.sup.2221, --CO.sub.2R.sup.2221, --CONR.sup.2221R.sup.3331, --NO.sub.2, --CN, --S(O).sub.j6aR.sup.2221, --SO.sub.2NR.sup.2221R.sup.3331, NR.sup.2221(C.dbd.O)R.sup.3331, NR.sup.2221(C.dbd.O)OR.sup.3331, NR.sup.2221(C.dbd.O)NR.sup.2221R.sup.3331, NR.sup.2221S(O).sub.j6aR.sup.3331, --(C.dbd.S)OR.sup.2221, --(C.dbd.O)SR.sup.2221, --NR.sup.2221(C.dbd.NR.sup.3331)NR.sup.222a1R.sup.333a1, --NR.sup.2221(C.dbd.NR.sup.3331)OR.sup.222a1, --NR.sup.2221(C.dbd.NR.sup.3331)SR.sup.333a1, --O(C.dbd.O)OR.sup.2221, --O(C.dbd.O)NR.sup.2221R.sup.3331, --O(C.dbd.O)SR.sup.2221, --S(C.dbd.O)OR.sup.2221, or --S(C.dbd.O)NR.sup.2221R.sup.3331 substituents.

20. The compound or salt of claim 1 wherein G.sup.11 is --OR.sup.21, --NR.sup.21R.sup.31, --CO.sub.2R.sup.21, --C(O)R.sup.21, --CONR.sup.21R.sup.31, NR.sup.21(C.dbd.O)R.sup.31, NR.sup.21(C.dbd.O)OR.sup.31, NR.sup.21(C.dbd.O)NR.sup.21R.sup.31, NR.sup.21S(O).sub.j4R.sup.31, --O(C.dbd.O)OR.sup.21, --O(C.dbd.O)NR.sup.21R.sup.31, C.sub.0-10alkyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, heterocyclyl-C.sub.0-10alkyl, or heterocyclyl-C.sub.2-10alkenyl, any of which is optionally substituted with one or more independent halo, oxo, --CF.sub.3, --OCF.sub.3, --OR.sup.2221, --NR.sup.2221R.sup.3331(R.sup.333a1).sub.j4a, --C(O)R.sup.2221, --CO.sub.2R.sup.2221, --CONR.sup.2221R.sup.3331, --NO.sub.2, --CN, --S(O).sub.j4aR.sup.2221, --SO.sub.2NR.sup.2221R.sup.3331, NR.sup.2221(C.dbd.O)R.sup.3331, NR.sup.2221(C.dbd.O)OR.sup.3331, NR.sup.2221(C.dbd.O)NR.sup.2221R.sup.3331, NR.sup.2221S(O).sub.j4aR.sup.3331, --(C.dbd.S)OR.sup.2221, --(C.dbd.O)SR.sup.2221, --NR.sup.2221(C.dbd.NR.sup.3331)NR.sup.222a1R.sup.333a1, --NR.sup.2221(C.dbd.NR.sup.3331)OR.sup.222a1, --NR.sup.2221(C.dbd.NR.sup.3331)SR.sup.333a1, --O(C.dbd.O)OR.sup.2221, --O(C.dbd.O)NR.sup.2221R.sup.3331, --O(C.dbd.O)SR.sup.2221, --S(C.dbd.O)OR.sup.2221, or --S(C.dbd.O)NR.sup.2221R.sup.3331 substituents.

21. The compound or salt of claim 1 wherein R.sup.4 is H, alkyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, cycloalkenyl, or heterocycloalkenyl, any of which is optionally substituted by one or more independent G.sup.41 substituents.

22. The compound or salt of claim 10 wherein R.sup.4 is alkyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, cycloalkenyl, or heterocycloalkenyl, any of which is optionally substituted by one or more independent G.sup.41 substituents.

23. The compound or salt of claim 11 wherein R.sup.4 is alkyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, cycloalkenyl, or heterocycloalkenyl, any of which is optionally substituted by one or more independent G.sup.41 substituents.

24. The compound or salt of claim 1 wherein Q.sup.1 is phenyl substituted by said one to five independent G.sup.1 substituents wherein at least one of said G.sup.1 substituents is --(X.sup.1).sub.n--(Y.sup.1).sub.m--R.sup.4, and wherein n=1 and X.sup.1 is 3-(--O--), m=1 and Y.sup.1 is --(--CH.sub.2--), and R.sup.4 is aryl optionally substituted by one or more independent G.sup.41 substituents.

25. The compound or salt of claim 24 wherein R.sup.1 is aryl, heteroaryl, cycloalkyl or heterocyclyl, optionally substituted by one or more independent G.sup.11 substituents.

26. The compound or salt of claim 25 wherein R.sup.1 is cycloalkyl or heterocyclyl, optionally substituted by one or more independent G.sup.11 substituents.

27. The compound or salt of claim 26 wherein R.sup.1 is cycloalkyl, optionally substituted by one or more independent G.sup.11 substituents.

28. The compound or salt of claim 27 wherein R.sup.1 is cyclobutyl, cyclopentyl or cyclohexyl, optionally substituted by one or more independent G.sup.11 substituents.

29. The compound or salt of claim 27 wherein G.sup.11 is --OR.sup.21, --NR.sup.21R.sup.31, --CO.sub.2R.sup.21, --C(O)R.sup.21, --CONR.sup.21R.sup.31, NR.sup.21(C.dbd.O)R.sup.31, NR.sup.21(C.dbd.O)OR.sup.31, NR.sup.21(C.dbd.O)NR.sup.21R.sup.31, NR.sup.21S(O).sub.j4R.sup.31, --O(C.dbd.O)OR.sup.21, --O(C.dbd.O)NR.sup.21R.sup.31, C.sub.0-10alkyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, heterocyclyl-C.sub.0-10alkyl, or heterocyclyl-C.sub.2-10alkenyl, any of which is optionally substituted with one or more independent halo, oxo, --CF.sub.3, --OCF.sub.3, --OR.sup.2221, --NR.sup.2221R.sup.3331(R.sup.333a1).sub.j4a, --C(O)R.sup.2221, --CO.sub.2R.sup.2221, --CONR.sup.2221R.sup.3331, --NO.sub.2, --CN, --S(O).sub.j4aR.sup.2221, --SO.sub.2NR.sup.2221R.sup.3331, NR.sup.2221(C.dbd.O)R.sup.3331, NR.sup.2221(C.dbd.O)OR.sup.3331, NR.sup.2221(C.dbd.O)NR.sup.2221R.sup.3331, NR.sup.2221S(O).sub.j4aR.sup.3331, --(C.dbd.S)OR.sup.2221, --(C.dbd.O)SR.sup.2221, --NR.sup.2221(C.dbd.NR.sup.3331)NR.sup.222a1R.sup.333a1, --NR.sup.2221(C.dbd.NR.sup.3331)OR.sup.222a1, --NR.sup.2221(C.dbd.NR.sup.3331)SR.sup.333a1, --O(C.dbd.O)OR.sup.2221, --O(C.dbd.O)NR.sup.2221R.sup.3331, --O(C.dbd.O)SR.sup.2221, --S(C.dbd.O)OR.sup.2221, or --S(C.dbd.O)NR.sup.2221R.sup.3331 substituents.

30. The compound or salt of claim 1 wherein Q.sup.1 is phenyl substituted by said one to five independent G.sup.1 substituents wherein at least one of said G.sup.1 substituents is --(X.sup.1).sub.n--(Y.sup.1).sub.m--R.sup.4, and wherein n=1 and X.sup.1 is 4-(--O--), m=1 and Y.sup.1 is --(--CH.sub.2--), and R.sup.4 is aryl optionally substituted by one or more independent G.sup.41 substituents.

31. The compound or salt of claim 30 wherein R.sup.1 is aryl, heteroaryl, cycloalkyl or heterocyclyl, optionally substituted by one or more independent G.sup.11 substituents.

32. The compound or salt of claim 31 wherein R.sup.1 is cycloalkyl or heterocyclyl, optionally substituted by one or more independent G.sup.11 substituents.

33. The compound or salt of claim 32 wherein R.sup.1 is cycloalkyl, optionally substituted by one or more independent G.sup.11 substituents.

34. The compound or salt of claim 33 wherein R.sup.1 is cyclobutyl, cyclopentyl or cyclohexyl, optionally substituted by one or more independent G.sup.11 substituents.

35. The compound or salt of claim 33 wherein G.sup.11 is --OR.sup.21, --NR.sup.21R.sup.31, --CO.sub.2R.sup.21, --C(O)R.sup.21, --CONR.sup.21R.sup.31, NR.sup.21(C.dbd.O)R.sup.31, NR.sup.21(C.dbd.O)OR.sup.31, NR.sup.21(C.dbd.O)NR.sup.21R.sup.31, NR.sup.21S(O).sub.j4R.sup.31, --O(C.dbd.O)OR.sup.21, --O(C.dbd.O)NR.sup.21R.sup.31, C.sub.0-10alkyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, heterocyclyl-C.sub.0-10alkyl, or heterocyclyl-C.sub.2-10alkenyl, any of which is optionally substituted with one or more independent halo, oxo, --CF.sub.3, --OCF.sub.3, --OR.sup.2221, --NR.sup.2221R.sup.3331(R.sup.333a1).sub.j4a, --C(O)R.sup.2221, --CO.sub.2R.sup.2221, --CONR.sup.2221R.sup.3331, --NO.sub.2, --CN, --S(O).sub.j4aR.sup.2221, --SO.sub.2NR.sup.2221R.sup.3331, NR.sup.2221(C.dbd.O)R.sup.3331, NR.sup.2221(C.dbd.O)OR.sup.3331, NR.sup.2221(C.dbd.O)NR.sup.2221R.sup.3331, NR.sup.2221S(O).sub.j4aR.sup.3331, --(C.dbd.S)OR.sup.2221, --(C.dbd.O)SR.sup.2221, --NR.sup.2221(C.dbd.NR.sup.3331)NR.sup.222a1R.sup.333a1, --NR.sup.2221(C.dbd.NR.sup.3331)OR.sup.222a1, --NR.sup.2221(C.dbd.NR.sup.3331)SR.sup.333a1, --O(C.dbd.O)OR.sup.2221, --O(C.dbd.O)NR.sup.2221R.sup.3331, --O(C.dbd.O)SR.sup.2221, --S(C.dbd.O)OR.sup.2221, or --S(C.dbd.O)NR.sup.2221R.sup.3331 substituents.

36. The compound or salt of claim 1 wherein Q.sup.1 is phenyl substituted by said one to five independent G.sup.1 substituents wherein at least one of said G.sup.1 substituents is --(X.sup.1).sub.n--(Y.sup.1).sub.m--R.sup.4, and wherein n=1 and X.sup.1 is 3-(--O--), m=0, and R.sup.4 is (C.sub.0-C.sub.8)alkyl or cycloalkyl optionally substituted by one or more independent G.sup.41 substituents.

37. The compound or salt of claim 36 wherein R.sup.1 is aryl, heteroaryl, cycloalkyl or heterocyclyl, optionally substituted by one or more independent G.sup.11 substituents.

38. The compound or salt of claim 37 wherein R.sup.1 is cycloalkyl or heterocyclyl, optionally substituted by one or more independent G.sup.11 substituents.

39. The compound or salt of claim 38 wherein R.sup.1 is cycloalkyl, optionally substituted by one or more independent G.sup.11 substituents.

40. The compound or salt of claim 39 wherein R.sup.1 is cyclobutyl, cyclopentyl or cyclohexyl, optionally substituted by one or more independent G.sup.11 substituents.

41. The compound or salt of claim 39 wherein G.sup.11 is --OR.sup.21, --NR.sup.21R.sup.31, --CO.sub.2R.sup.21, --C(O)R.sup.21, --CONR.sup.21R.sup.31, NR.sup.21(C.dbd.O)R.sup.31, NR.sup.21(C.dbd.O)OR.sup.31, NR.sup.21(C.dbd.O)NR.sup.21R.sup.31, NR.sup.21S(O).sub.j4R.sup.31, --O(C.dbd.O)OR.sup.21, --O(C.dbd.O)NR.sup.21R.sup.31, C.sub.0-10alkyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, heterocyclyl-C.sub.0-10alkyl, or heterocyclyl-C.sub.2-10alkenyl, any of which is optionally substituted with one or more independent halo, oxo, --CF.sub.3, --OCF.sub.3, --OR.sup.2221, --NR.sup.2221R.sup.3331(R.sup.333a1).sub.j4a, --C(O)R.sup.2221, --CO.sub.2R.sup.2221, --CONR.sup.2221R.sup.3331, --NO.sub.2, --CN, --S(O).sub.j4aR.sup.2221, --SO.sub.2NR.sup.2221R.sup.3331, NR.sup.2221(C.dbd.O)R.sup.3331, NR.sup.2221(C.dbd.O)OR.sup.3331, NR.sup.2221(C.dbd.O)NR.sup.2221R.sup.3331, NR.sup.2221S(O).sub.j4aR.sup.3331, --(C.dbd.S)OR.sup.2221, --(C.dbd.O)SR.sup.2221, --NR.sup.2221(C.dbd.NR.sup.3331)NR.sup.222a1R.sup.333a1, --NR.sup.2221(C.dbd.NR.sup.3331)OR.sup.222a1, --NR.sup.2221(C.dbd.NR.sup.3331)SR.sup.333a1, --O(C.dbd.O)OR.sup.2221, --O(C.dbd.O)NR.sup.2221R.sup.3331, --O(C.dbd.O)SR.sup.2221, --S(C.dbd.O)OR.sup.2221, or --S(C.dbd.O)NR.sup.2221R.sup.3331 substituents.

42. The compound or salt of claim 36 wherein R.sup.4 is (C.sub.0-C.sub.6)alkyl.

43. The compound or salt of claim 41 wherein R.sup.4 is (C.sub.0-C.sub.6)alkyl.

44. The compounds or salts of claim 36 wherein R.sup.4 is H or methyl.

45. The compound or salt of claim 43 wherein R.sup.4 is H or methyl.

46. The compound or salt of claim 1 wherein Q.sup.1 is phenyl substituted by said one to five independent G.sup.1 substituents wherein at least one of said G.sup.1 substituents is --(X.sup.1).sub.n--(Y.sup.1).sub.m--R.sup.4, and wherein n=1 and X.sup.1 is 3-(--O--), m=0, and R.sup.4 is aryl optionally substituted by one or more independent G.sup.41 substituents.

47. The compound or salt of claim 46 wherein R.sup.1 is aryl, heteroaryl, cycloalkyl or heterocyclyl, optionally substituted by one or more independent G.sup.11 substituents.

48. The compound or salt of claim 46 wherein R.sup.1 is cycloalkyl or heterocyclyl, optionally substituted by one or more independent G.sup.11 substituents.

49. The compound or salt of claim 48 wherein R.sup.1 is cyclobutyl, cyclopentyl or cyclohexyl, optionally substituted by one or more independent G.sup.11 substituents.

50. The compound or salt of claim 48 wherein G.sup.11 is --OR.sup.21, --NR.sup.21R.sup.31, --CO.sub.2R.sup.21, --C(O)R.sup.21, --CONR.sup.21R.sup.31, NR.sup.21(C.dbd.O)R.sup.31, NR.sup.21(C.dbd.O)OR.sup.31, NR.sup.21(C.dbd.O)NR.sup.21R.sup.31, NR.sup.21S(O).sub.j4R.sup.31, --O(C.dbd.O)OR.sup.21, --O(C.dbd.O)NR.sup.21R.sup.31, C.sub.0-10alkyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, heterocyclyl-C.sub.0-10alkyl, or heterocyclyl-C.sub.2-10alkenyl, any of which is optionally substituted with one or more independent halo, oxo, --CF.sub.3, --OCF.sub.3, --OR.sup.2221, --NR.sup.2221R.sup.3331(R.sup.333a1).sub.j4a, --C(O)R.sup.2221, --CO.sub.2R.sup.2221, --CONR.sup.2221R.sup.3331, --NO.sub.2, --CN, --S(O).sub.j4aR.sup.2221, --SO.sub.2NR.sup.2221R.sup.3331, NR.sup.2221(C.dbd.O)R.sup.3331, NR.sup.2221(C.dbd.O)OR.sup.3331, NR.sup.2221(C.dbd.O)NR.sup.2221R.sup.3331, NR.sup.2221S(O).sub.j4aR.sup.3331, --(C.dbd.S)OR.sup.2221, --(C.dbd.O)SR.sup.2221, --NR.sup.2221(C.dbd.NR.sup.3331)NR.sup.222a1R.sup.333a1, --NR.sup.2221(C.dbd.NR.sup.3331)OR.sup.222a1, --NR.sup.2221(C.dbd.NR.sup.3331)SR.sup.333a1, --O(C.dbd.O)OR.sup.2221, --O(C.dbd.O)NR.sup.2221R.sup.3331, --O(C.dbd.O)SR.sup.2221, --S(C.dbd.O)OR.sup.2221, or --S(C.dbd.O)NR.sup.2221R.sup.3331 substituents.

51. The compound or salt of claim 46 wherein R.sup.4 is phenyl optionally substituted with G.sup.41.

52. The compound or salt of claim 1 wherein Q.sup.1 is phenyl substituted by said one to five independent G.sup.1 substituents wherein at least one of said G.sup.1 substituents is --(X.sup.1).sub.n--(Y.sup.1).sub.m--R.sup.4, and wherein n=1 and X.sup.1 is 3- or 4-(--NH--), m=1 and Y.sup.1 is --(--SO.sub.2--), and R.sup.4 is aryl optionally substituted by one or more independent G.sup.41 substituents.

53. The compound or salt of claim 52 wherein R.sup.1 is aryl, heteroaryl, cycloalkyl or heterocyclyl, optionally substituted by one or more independent G.sup.11 substituents.

54. The compound or salt of claim 53 wherein R.sup.1 is cycloalkyl or heterocyclyl, optionally substituted by one or more independent G.sup.11 substituents.

55. The compound or salt of claim 54 wherein R.sup.1 is cyclobutyl, cyclopentyl or cyclohexyl, optionally substituted by one or more independent G.sup.11 substituents.

56. The compound or salt of claim 54 wherein G.sup.11 is --OR.sup.21, --NR.sup.21R.sup.31, --CO.sub.2R.sup.21, --C(O)R.sup.21, --CONR.sup.21R.sup.31, NR.sup.21(C.dbd.O)R.sup.31, NR.sup.21(C.dbd.O)OR.sup.31, NR.sup.21(C.dbd.O)NR.sup.21R.sup.31, NR.sup.21S(O).sub.j4R.sup.31, --O(C.dbd.O)OR.sup.21, --O(C.dbd.O)NR.sup.21R.sup.31, C.sub.0-10alkyl, cycloC.sub.3-8alkyl, cycloC.sub.3-8alkenyl, heterocyclyl-C.sub.0-10alkyl, or heterocyclyl-C.sub.2-10alkenyl, any of which is optionally substituted with one or more independent halo, oxo, --CF.sub.3, --OCF.sub.3, --OR.sup.2221, --NR.sup.2221R.sup.3331(R.sup.333a1).sub.j4a, --C(O)R.sup.2221, --CO.sub.2R.sup.2221, --CONR.sup.2221R.sup.3331, --NO.sub.2, --CN, --S(O).sub.j4aR.sup.2221, --SO.sub.2NR.sup.2221R.sup.3331, NR.sup.2221(C.dbd.O)R.sup.3331, NR.sup.2221(C.dbd.O)R.sup.3331, NR.sup.2221(C.dbd.O)NR.sup.2221R.sup.3331, NR.sup.2221S(O).sub.j4aR.sup.3331, --(C.dbd.S)OR.sup.2221, --(C.dbd.O)SR.sup.2221, --NR.sup.2221(C.dbd.NR.sup.3331)NR.sup.222a1R.sup.333a1, --NR.sup.2221(C.dbd.NR.sup.3331)OR.sup.222a1, --NR.sup.2221(C.dbd.NR.sup.3331)SR.sup.333a1, --O(C.dbd.O)OR.sup.2221, --O(C.dbd.O)NR.sup.2221R.sup.3331, --O(C.dbd.O)SR.sup.2221, --S(C.dbd.O)OR.sup.2221, or --S(C.dbd.O)NR.sup.2221R.sup.3331 substituents.

57. The compound or salt of claim 56 wherein R.sup.1 is cis- or trans-cyclobutyl substituted at the 3-position by G.sup.11 wherein G.sup.11 is --OH, --NH.sub.2, --N(CH.sub.3).sub.2, --NHAc, --NH(CO)NHCH.sub.3, --NH(CO)OCH.sub.3, --CH.sub.2OH, --CH.sub.2NH.sub.2, --CH.sub.2NHAc, CO.sub.2H, CONH.sub.2, --CH.sub.2N(CH.sub.3).sub.2, --CH.sub.2NH(CO)NHMe, --CH.sub.2NH(CO)OCH.sub.3, CO.sub.2CH.sub.3, CONHCH.sub.3, ##STR00448##

58. The compound or salt of claim 56 wherein R.sup.1 is cis- or trans-cyclohexyl substituted at the 4-position by G.sup.11 wherein G.sup.11 is --OH, --NH.sub.2, --N(CH.sub.3).sub.2, --NHAc, --NH(CO)NHCH.sub.3, --NH(CO)OCH.sub.3, --CH.sub.2OH, --CH.sub.2NH.sub.2, --CH.sub.2NHAc, CO.sub.2H, CONH.sub.2, --CH.sub.2N(CH.sub.3).sub.2, --CH.sub.2NH(CO)NHMe, --CH.sub.2NH(CO)OCH.sub.3, CO.sub.2CH.sub.3, CONHCH.sub.3, ##STR00449##

59. A compound selected from the group consisting of: [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine], 1-(3-Benzyloxyphenyl)-3-phenyl-imidazo[1,5-a]pyrazin-8-ylamine, 3-Benzyl-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxyphenyl)-3-naphthalen-1-yl-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxyphenyl)-3-naphthalen-2-yl-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxy-phenyl)-3-cyclopentyl-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxy-phenyl)-3-cyclohexyl-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxy-phenyl)-3-cycloheptyl-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxy-phenyl)-3-(tetrahydro-furan-3-yl)-imidazo[1,5-a]pyrazin-8-- ylamine, trans-3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-y- l]-cyclobutanol, 1-(3-Benzyloxy-phenyl)-3-(1-methyl-piperidin-4-yl)-imidazo[1,5-a]pyrazin-- 8-ylamine, cis-4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-y- l]-cyclohexanecarboxylic acid amide, trans-4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclo- hexanecarboxylic acid amide, cis-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cycloh- exyl}-methanol, trans-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cycl- ohexyl}-methanol, cis-2-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cycl- ohexylmethyl}-isoindole-1,3-dione, trans-2-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cy- clohexylmethyl}-isoindole-1,3-dione, cis-3-(4-Aminomethyl-cyclohexyl)-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyr- azin-8-ylamine, trans-3-(4-Aminomethyl-cyclohexyl)-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]p- yrazin-8-ylamine, cis-N-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cycl- ohexylmethyl}-acetamide, or trans-N-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cy- clohexylmethyl}-acetamide. or pharmaceutically acceptable salts thereof.

60. A compound selected from the group consisting of: trans-N-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cy- clohexylmethyl}-acetamide, 1-Biphenyl-3-yl-3-cyclobutylimidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Bromo-phenyl)-3-cyclobutylimidazo[1,5-a]pyrazin-8-ylamine, 1-(4'-t-Butylbiphenyl-3-yl)-3-cyclobutylimidazo[1,5-a]pyrazin-8-ylamine, 3-Cyclobutyl-1-(4'-methylbiphenyl-3-yl)-imidazo[1,5-a]pyrazin-8-ylamine, 3-Cyclobutyl-1-(4'-methoxybiphenyl-3-yl)-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxyphenyl)-3-cyclopentylmethylimidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxyphenyl)-3-cyclohexylmethylimidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxyphenyl)-3-trifluoromethylimidazo[1,5-a]pyrazin-8-ylamine, 4-[8-Amino-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]-benzamide, 3-Cyclobutyl-1-phenylimidazo[1,5-a]pyrazin-8-ylamine, (trans-3-(4-Azetidin-1-ylmethyl-cyclohexyl)-1-(3-benzyloxy-phenyl)-imidaz- o[1,5-a]pyrazin-8-ylamine, trans-1-(3-Benzyloxy-phenyl)-3-(4-pyrrolidin-1-ylmethyl-cyclohexyl)-imida- zo[1,5-a]pyrazin-8-ylamine), trans-4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclo- hexanecarboxylic acid methyl ester, (trans-4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cycl- ohexanecarboxylic acid, (trans-4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cycl- ohexanecarboxylic acid methylamide, 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexane- carboxylic acid ethylamide, trans-1-(3-Benzyloxy-phenyl)-3-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-imida- zo[1,5-a]pyrazin-8-ylamine, cis-1-(3-Benzyloxy-phenyl)-3-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-imidazo- [1,5-a]pyrazin-8-ylamine, trans-3-(3-Azetidin-1-ylmethylcyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1- ,5-a]pyrazin-8-ylamine, cis-3-(3-Azetidin-1-ylmethylcyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1,5- -a]pyrazin-8-ylamine, toluene-4-sulfonic acid 3-[8-amino-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]cyclobutylmet- hyl ester, {3-[8-Amino-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]cy- clobutyl}methanol, 3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cy- clobutanol, 3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-1-ethyl-cyc- lobutanol, 1-Allyl-3-[8-amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin- -3-yl]-cyclobutanol, 1-(3-Benzyloxyphenyl)-3-tert-butylimidazo[1,5-a]pyrazin-8-ylamine, cis-1-[3-(Benzyloxy)phenyl]-3-[3-(dimethylamino) cyclobutyl]imidazo[1,5-a]pyrazin-8-amine, 3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenol, 3-Cyclobutyl-1-[3-(4-fluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-yl- amine, trans-4-[8-Amino-1-(3-hydroxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]cy- clohexanecarboxylic acid methyl ester, 3-[8-Amino-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]-benzamide, {3-[8-Amino-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]-phenyl}-met- hanol, 3-(3-Aminomethylphenyl)-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin- -8-ylamine, 2-{3-[8-Amino-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]-benzyl}-i- soindole-1,3-dione, 4-{8-Amino-1-[3-(2,6-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-3-- yl}-cyclohexanecarboxylic acid, cis-3-(3-Dimethylaminomethyl-cyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1,- 5-a]pyrazin-8-ylamine, cis-3-(3-Azetidin-1-ylmethylcyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1,5- -a]pyrazin-8-ylamine, cis-3-(3-Pyrrolidin-1-ylmethylcyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1- ,5-a]pyrazin-8-ylamine, cis-3-(3-Azidomethyl-cyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyra- zin-8-ylamine, cis-3-(3-aminomethyl-cyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyra- zin-8-ylamine, cis-3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobu- tane-carboxylic acid amide, trans-3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclo- butane-carboxylic acid amide, 3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-1-hydroxyme- thyl-cyclobutanol, cis-Toluene-4-sulfonic acid 3-[8-amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-1-hydroxy-c- yclobutylmethyl ester, trans-Toluene-4-sulfonic acid 3-[8-amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-1-hydroxy-c- yclobutylmethyl ester, trans-3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-1-aze- tidin-1-ylmethyl-cyclobutanol, cis-3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-1-azeti- din-1-ylmethyl-cyclobutanol, 1-[3-(4-tert-Butoxy-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin- -8-ylamine, 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-ben- zonitrile, 3-Cyclobutyl-1-[3-(2-nitro-benzyloxy)-phenyl]-imidazo[1,5-a]pyr- azin-8-ylamine, 1-[3-(2-Bromo-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yla- mine, 1-[3-(3-Aminomethyl-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]py- razin-8-ylamine, 3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-ben- zoic acid methyl ester, 3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-ben- zamide, {3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymet- hyl]-phenyl}-methanol, 2-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-- benzyl}-isoindole-1,3-dione, 3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-ben- zoic acid, 3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxym- ethyl]-N-methyl-benzamide, 1-(3-Benzyloxy-phenyl)-3-(3-methoxymethylene-cyclobutyl)-imidazo[1,5-a]py- razin-8-ylamine, 3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]cyclobutanec- arbaldehyde, cis-1-(3-Benzyloxy-phenyl)-3-(4-methoxy-cyclohexyl)-imidazo[1,5-a]pyrazin- -8-ylamine, trans-1-(3-Benzyloxy-phenyl)-3-(4-methoxy-cyclohexyl)-imidazo[1,5-a]pyraz- in-8-ylamine, cis-tert-Butyl ({3-[8-amino-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobutyl- }oxy)acetate, cis-2-{3-[8-Amino-1-(3-benzyloxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobu- toxy}ethanol, cis-Toluene-4-sulfonic acid 2-{3-[8-amino-1-(3-benzyloxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutoxy- }ethyl ester, cis-1-(3-Benzyloxyphenyl)-3-[3-(2-dimethylaminoethoxy)-cyclobutyl]imidazo- [1,5-a]pyrazin-8-yl amine, cis-{3-[8-Amino-1-(3-benzyloxyphenyl)imidazo[1,5-a]pyrazin-3-yl]-cyclobut- oxy}acetic acid, cis-2-{3-[8-Amino-1-(3-benzyloxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobu- toxy}-N-methylacetamide, cis-2-{3-[8-Amino-1-(3-benzyloxy-phenyl)imidazo[1,5-a]pyrazin-3-yl]cyclob- utoxy}acetamide, 1-(3-benzyloxy-4-methoxyphenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylam- ine, 1-(3-Benzyloxy-4-fluorophenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-y- lamine, 1-(3-Benzyloxy-4-isopropoxyphenyl)-3-cyclobutylimidazo[1,5-a]pyraz- in-8-ylamine, 1-(3-Benzyloxy-4-ethoxyphenyl)-3-cyclobutylimidazo[1,5-a]pyrazin-8-ylamin- e, 4-(8-Amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)-2-benzyloxyphenol, 4-{8-Amino-1-[3-(2,6-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-3-- yl}-cyclohexanecarboxylic acid amide, 4-{8-Amino-1-[3-(2,6-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-3-- yl}-cyclohexanecarboxylic acid methylamide, N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-- phenyl}-acetamide, or pharmaceutically acceptable salts thereof.

61. A compound selected from the group consisting of: TABLE-US-00010 Structure Name ##STR00450## N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-benzamide ##STR00451## N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-butyramide ##STR00452## N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-2-hydroxy-propionamide ##STR00453## N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-2-morpholin-4-yl-acetamide ##STR00454## N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-2-methoxy-propionamide ##STR00455## Tetrahydro-furan-2-carboxylic acid {3-[3-(8-amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-ph- enyl}-amide ##STR00456## Pyrrolidine-2-carboxylic acid {3-[3-(8-amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-ph- enyl}-amide ##STR00457## N-{3-[3-(8-Amino-3-cyc1obutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-methanesulfonamide ##STR00458## N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-nicotinamide ##STR00459## N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-2-(2-oxo-pyrrolidin-1-yl)-acetamide ##STR00460## N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-2-pyridin-4-yl-acetamide ##STR00461## N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-2-pyridin-2-yl-acetamide ##STR00462## N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-benzenesulfonamide ##STR00463## N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-isonicotinamide ##STR00464## Pyridine-2-carboxylic acid {3-[3-(8-amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-ph- enyl}-amide ##STR00465## 1-Methyl-1H-imidazole-4-sulfonic acid {3-[3-(8-amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-ph- enyl}-amide

or a pharmaceutically acceptable salt thereof.

62. A compound selected from the group consisting of: TABLE-US-00011 Structure Name ##STR00466## N-{2-[3-(8-Amino-3-cyclobutyl-imidazol[1,5-a]pyrazin-1-yl)-phenoxymethyl- ]-phenyl}-benzamide ##STR00467## N-{2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-2-morpholin-4-yl-acetamide ##STR00468## N-{2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-2-methoxy-propionamide ##STR00469## Tetrahydro-furan-2-carboxylic acid {2-[3-(8-amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-ph- enyl}-amide ##STR00470## N-{2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-2-hydroxy-propionamide ##STR00471## N-{2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-nicotinamide ##STR00472## N-{2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-2-pyridin-2-yl-acetamide ##STR00473## N-{2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]- -phenyl}-isonicotmamide

or a pharmaceutically acceptable salt thereof.

63. A compound selected from the group consisting of: TABLE-US-00012 ##STR00474## R1 Name ##STR00475## 1-(3-Benzyloxy-phenyl)-3-(4-phenylaminomethyl-cyclohexyl)-imidazo[1,5-a]- pyrazin-8-ylamine ##STR00476## 1-(3-Benzyloxy-phenyl)-3-(4-morpholin-4-ylmethyl-cyclohexyl)-imidazo[1,5- -a]pyrazin-8-ylamine ##STR00477## 1-(3-Benzyloxy-phenyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-cyclohexyl]-- imidazo[1,5-a]pyrazin-8-ylamine ##STR00478## 1-(3-Benzyloxy-phenyl)-3-(4-diethylaminomethyl-cyclohexyl)-imidazo[1,5-a- ]pyrazin-8-ylamine ##STR00479## 1-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohe- xylmethyl}-piperidin-4-ol ##STR00480## 3-(4-Azepan-1-ylmethyl-cyclohexyl)-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]- pyrazin-8-ylamine ##STR00481## 1-(3-Benzyloxy-phenyl)-3-{4-[(ethyl-methyl-amino)-methyl]-cyclohexyl}-im- idazo[1,5-a]pyrazin-8-ylamine ##STR00482## 1-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohe- xylmethyl}-piperidin-3-ol ##STR00483## N-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohe- xylmethyl}-N,N',N'-trimethyl-ethane-1,2-diamine ##STR00484## 2-({4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cycloh- exylmethyl}-methyl-amino)-ethanol ##STR00485## 4-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohe- xylmethyl}-piperazin-2-one ##STR00486## 1-(3-Benzyloxy-phenyl)-3-[4-(2,5-dihydro-pyrrol-1-ylmethyl)-cyclohexyl]-- imidazo[1,5-a]pyrazin-8-ylamine ##STR00487## 1-(3-Benzyloxy-phenyl)-3-(4-propylaminomethyl-cyclohexyl)-imidazo[1,5-a]- pyrazin-8-ylamine ##STR00488## 3-[4-(Benzylamino-methyl)-cyclohexyl]-1-(3-benzyloxy-phenyl)-imidazo[1,5- -a]pyrazin-8-ylamine ##STR00489## 1-(3-Benzyloxy-phenyl)-3-[4-(isopropylamino-methyl)-cyclohexyl]-imidazo[- 1,5-a]pyrazin-8-ylamine ##STR00490## 1-(3-Benzyloxy-phenyl)-3-(4-butylaminomethyl-cyclohexyl)-imidazo[1,5-a]p- yrazin-8-ylamine ##STR00491## N-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohe- xylmethyl}-N',N'-dimethyl-ethane-1,2-diamine ##STR00492## 2-({4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cycloh- exylmethyl}-amino)-ethanol ##STR00493## (1-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cycloh- exylmethyl}-piperidin-3-yl)-methanol ##STR00494## (1-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cycloh- exylmethyl}-piperidin-4-yl)-methanol ##STR00495## 1-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohe- xylmethyl}-pyrrolidin-3-ol ##STR00496## 1-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohe- xylmethyl}-pyrrolidin-3-ol ##STR00497## 1-(3-Benzyloxy-phenyl)-3-(4-{[(tetrahydro-furan-2-ylmethyl)-amino]-methy- l}-cyclohexyl)-imidazo[1,5-a]pyrazin-8-ylamine ##STR00498## N-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohe- xylmethyl}-N',N'-dimethyl-propane-1,3-diamine ##STR00499## 1-({4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cycloh- exylmethyl}-amino)-propan-2-ol ##STR00500## 3-({4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cycloh- exylmethyl}-amino)-propan-1-ol ##STR00501## 1-(3-Benzyloxy-phenyl)-3-(4-{[(pyridin-3-ylmethyl)-amino]-methyl}-cycloh- exyl)-imidazo[1,5-a]pyrazin-8-ylamine ##STR00502## 1-(3-Benzyloxy-phenyl)-3-{4-[(2-pyrrolidin-1-yl-ethylamino)-methyl]-cycl- ohexyl}-imidazo[1,5-a]pyrazin-8-ylamine ##STR00503## N-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohe- xylmethyl}-N',N'-diethyl-ethane-1,2-diamine ##STR00504## 1-(3-Benzyloxy-phenyl)-3-{4-[(1-methyl-piperidin-4-ylamino)-methyl]-cycl- ohexyl}-imidazo[1,5-a]pyrazin-8-ylamine ##STR00505## N-[2-({4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyc- lohexylmethyl}-amino)-ethyl]-acetamide ##STR00506## 1-(3-Benzyloxy-phenyl)-3-(4-piperidin-1-ylmethyl-cyclohexyl)-imidazo[I ,5-a]pyrazin-8-ylamine

or a pharmaceutically acceptable salt thereof, wherein * is the point of attachment.

64. A compound selected from the group consisting of: TABLE-US-00013 ##STR00507## R1 Name ##STR00508## 1-(3-Benzyloxy-phenyl)-3-(3-phenylaminomethyl-cyclobutyl)-imidazo[1,5-a]- pyrazin-8-ylamine ##STR00509## 1-(3-Benzyloxy-phenyl)-3-{3-[(ethyl-methyl-amino)-methyl]-cyclobutyl}-im- idazo[1,5-a]pyrazin-8-ylamine ##STR00510## 1-(3-Benzyloxy-phenyl)-3-[3-(2-methyl-pyrrolidin-1-ylmethyl)-cyclobutyl]- -imidazo[1,5-a]pyrazin-8-ylamine ##STR00511## 1-(3-Benzyloxy-phenyl)-3-(3-piperidin-1-ylmethyl-cyclobutyl)-imidazo[1,5- -a]pyrazin-8-ylamine ##STR00512## 1-(3-Benzyloxy-phenyl)-3-(3-butylaminomethyl-cyclobutyl)-imidazo[1,5-a]p- yrazin-8-ylamine ##STR00513## 1-(3-Benzyloxy-phenyl)-3-[3-(2,5-dihydro-pyrrol-1-ylmethyl)-cyclobutyl]-- imidazo[1,5-a]pyrazin-8-ylamine ##STR00514## 3-(3-Azepan-1-ylmethyl-cyclobutyl)-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]- pyrazin-8-ylamine ##STR00515## 1-(3-Benzyloxy-phenyl)-3-(3-propylaminomethyl-cyclobutyl)-imidazo[1,5-a]- pyrazin-8-ylamine ##STR00516## 4-{3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobu- tylmethyl}-piperazin-2-one ##STR00517## 3-[3-(Benzylamino-methyl)-cyclobutyl]-1-(3-benzyloxy-phenyl)-imidazol[1,- 5-a]pyrazin-8-ylamine ##STR00518## 1-(3-Benzyloxy-phenyl)-3-[3-(4-methyl-piperazin-1-ylmethyl)-cyclobutyl]-- imidazo[1,5-a]pyrazin-8-ylamine ##STR00519## 2-({3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclob- utylmethyl}-methyl-amino)-ethanol ##STR00520## 1-{3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobu- tylmethyl}-piperidin-4-ol ##STR00521## 1-(3-Benzyloxy-phenyl)-3-[3-(isopropylamino-methyl)-cyclobutyl]-imidazo[- 1,5-a]pyrazin-8-ylamine ##STR00522## 1-(3-Benzyloxy-phenyl)-3-(3-morpholin-4-ylmethyl-cyclobutyl)-imidazo[1,5- -a]pyrazin-8-ylamine ##STR00523## N-[2-({3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyc- lobutylmethyl}-amino)-ethyl]-acetamide ##STR00524## 1-{3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobu- tylmethyl}-piperidin-3-ol ##STR00525## 2-({3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclob- utylmethyl}-amino)-ethanol ##STR00526## 1-(3-Benzyloxy-phenyl)-3-[3-(4-methyl-piperazin-1-ylmethyl)-cyclobutyl]-- imidazo[1,5-a]pyrazin-8-ylamine

or a pharmaceutically acceptable salt thereof, wherein * is the point of attachment.

65. A compound selected from the group consisting of: TABLE-US-00014 ##STR00527## R1 Name ##STR00528## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid (2-diethylamino-ethyl)-amide ##STR00529## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid (2-methoxy-ethyl)-amide ##STR00530## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid (2-hydroxy-ethyl)-amide ##STR00531## {4-[8-Amino-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexyl}- -morpholin-4-yl-methanone ##STR00532## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid benzylamide ##STR00533## {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexy- l}-(4-hydroxy-piperidin-1-yl)-methanone ##STR00534## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid (2-hydroxy-ethyl)-methyl-amide ##STR00535## {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexy- l}-azepan-1-yl-methanone ##STR00536## {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexy- l}-piperidin-1-yl-methanone ##STR00537## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid butylamide ##STR00538## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid (2-acetylamino-ethyl)-amide ##STR00539## {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexy- l}-(3-hydroxy-piperidin-1-yl)-methanone ##STR00540## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid (2-dimethylamino-ethyl)-methyl-amide ##STR00541## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid ethyl-methyl-amide ##STR00542## {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexy- l}-pyrrolidin-1-yl-methanone ##STR00543## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid cyclopropylamide ##STR00544## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid phenylamide ##STR00545## {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexy- l}-(4-methyl-piperazin-1-yl)-methanone ##STR00546## 4-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohe- xanecarbonyl}-piperazin-2-one ##STR00547## {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexy- l}-(3-hydroxymethyl-piperidin-1-yl)-methanone ##STR00548## {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexy- l}-(4-hydroxymethyl-piperidin-1-yl)-methanone ##STR00549## {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexy- l}-(3-hydroxy-pyrrolidin-1-yl)-methanone ##STR00550## {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexy- l}-(3-hydroxy-pyrrolidin-1-yl)-methanone ##STR00551## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid (pyridin-2-ylmethyl)-amide ##STR00552## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid (tetrahydro-furan-2-ylmethyl)-amide ##STR00553## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid (3-dimethylamino-propyl)-amide ##STR00554## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid (2-hydroxy-propyl)-amide ##STR00555## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazol[1,5-a]pyrazin-3-yl]-cyclohexa- necarboxylic acid (3-hydroxy-propyl)-amide ##STR00556## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid (pyridin-3-ylmethyl)-amide ##STR00557## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid (pyridin-4-ylmethyl)-amide ##STR00558## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide ##STR00559## {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexy- l}-azetidin-1-yl-methanone ##STR00560## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazol[1,5-a]pyrazin-3-yl]-cyclohexa- necarboxylic acid (1-methyl-piperidin-4-yl)-amide ##STR00561## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid [2-(1H-imidazol-4-yl)-ethyl]-amide ##STR00562## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid propylamide ##STR00563## 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexan- ecarboxylic acid isobutyl-amide

or a pharmaceutically acceptable salt thereof, wherein * is the point of attachment.

66. A compound selected from the group consisting of: TABLE-US-00015 ##STR00564## R1 Name ##STR00565## 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-ethanol ##STR00566## 3-Cyclobutyl-1-(3-phenethyloxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylamine ##STR00567## 3-Cyclobutyl-1-(3-isobutoxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylamine ##STR00568## 3-Cyclobutyl-1-[3-(3-morpholin-4-yl-propoxy)-phenyl]-imidazo[1,5-a]pyraz- in-8-ylamine ##STR00569## 3-Cyclobutyl-1-[3-(2-piperidin-1-yl-ethoxy)-phenyl]-imidazo[1,5-a]pyrazi- n-8-ylamine ##STR00570## 3-Cyclobutyl-1-(3-cyclohexylmethoxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylam- ine ##STR00571## 3-Cyclobutyl-1-[3-(2-imidazol-1-yl-ethoxy)-phenyl]-imidazo[1,5-a]pyrazin- -8-ylamine ##STR00572## [3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-acetic acid tert-butyl ester ##STR00573## 1-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-butan-2-- one ##STR00574## [3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-acetic acid methyl ester ##STR00575## 3-Cyclobutyl-1-(3-methoxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylamine ##STR00576## 3-Cyclobutyl-1-[3-(3-methyl-but-2-enyloxy)-phenyl]-imidazo[1,5-a]pyrazin- -8-ylamine ##STR00577## 3-Cyclobutyl-1-[3-(2-diethylamino-ethoxy)-phenyl]-imidazo[1,5-a]pyrazin-- 8-ylamine ##STR00578## [3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-acetonitri- le ##STR00579## 3-Cyclobutyl-1-(3-cyclohexylmethoxy-phenyl)-imidazol[1,5-a]pyrazin-8-yla- mine ##STR00580## 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-acetamid- e ##STR00581## 3-Cyclobutyl-1-(3-cyclopropylmethoxy-phenyl)-imidazo[1,5-a]pyrazin-8-yla- mine ##STR00582## 3-Cyclobutyl-1-(3-cyclopentylmethoxy-phenyl)-imidazo[1,5-a]pyrazin-8-yla- mine ##STR00583## 3-Cyclobutyl-1-[3-(2-methoxy-ethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-yla- mine ##STR00584## 3-Cyclobutyl-1-[3-(3-methyl-butoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylam- ine ##STR00585## 3-Cyclobutyl-1-[3-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-imidazo[1,5-a]pyraz- in-8-ylamine ##STR00586## 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-1-morpho- lin-4-yl-ethanone ##STR00587## 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-1-pyrrol- idin-1-yl-ethanone ##STR00588## 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-N-propyl- -acetamide ##STR00589## 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-N-methyl- -acetamide

or a pharmaceutically acceptable salt thereof, wherein * is the point of attachment.

67. A compound selected from the group consisting of: TABLE-US-00016 ##STR00590## R1 Name ##STR00591## 3-Cyclobutyl-1-[3-(3-methoxy-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-- ylamine ##STR00592## 1-[3-(2-Chloro-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-y- lamine ##STR00593## 1-[3-(3-Chloro-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-y- lamine ##STR00594## 1-[3-(4-Chloro-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-y- lamine ##STR00595## 3-Cyclobutyl-1-[3-(pyridin-3-ylmethoxy)-phenyl]-imidazol[1,5-a]pyrazin-8- -ylamine ##STR00596## 3-Cyclobutyl-1-[3-(5-methyl-isoxazol-3-ylmethoxy)-phenyl]-imidazo[1,5-a]- pyrazin-8-ylamine ##STR00597## 3-Cyclobutyl-1-[3-(2,6-dichloro-pyridin-4-ylmethoxy)-phenyl]-imidazol[1,- 5-a]pyrazin-8-ylamine ##STR00598## 1-[3-(Biphenyl-4-ylmethoxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8- -ylamine ##STR00599## 1-[3-(2-Benzenesulfonyl-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]py- razin-8-ylamine ##STR00600## 3-Cyclobutyl-1-[3-(naphthalen-2-ylmethoxy)-phenyl]-imidazo[1,5-a]pyrazin- -8-ylamine ##STR00601## 3-Cyclobutyl-1-[3-(4-[1,2,4]triazol-1-yl-benzyloxy)-phenyl]-imidazo[1,5-- a]pyrazin-8-ylamine ##STR00602## 3-Cyclobutyl-1-[3-(4-methyl-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-y- lamine ##STR00603## 3-Cyclobutyl-1-[3-(2,6-dichloro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin- -8-ylamine ##STR00604## 3-Cyclobutyl-1-[3-(3-trifluoromethyl-benzyloxy)-phenyl]-imidazo[1,5-a]py- razin-8-ylamine ##STR00605## 1-[3-(4-tert-Butyl-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin- -8-ylamine ##STR00606## 1-[3-(Biphenyl-2-ylmethoxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8- -ylamine ##STR00607## 4-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-be- nzonitrile ##STR00608## 3-Cyclobutyl-1-[3-(2,3-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin- -8-ylamine ##STR00609## 3-Cyclobutyl-1-[3-(3,5-dimethyl-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin- -8-ylamine ##STR00610## 3-Cyclobutyl-1-[3-(3-trifluoromethoxy-benzyloxy)-phenyl]-imidazo[1,5-a]p- yrazin-8-ylamine ##STR00611## 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-be- nzonitrile ##STR00612## 3-Cyclobutyl-1-[3-(4-trifluoromethoxy-benzyloxy)-phenyl]-imidazo[1,5-a]p- yrazin-8-ylamine ##STR00613## 3-Cyclobutyl-1-[3-(3,4-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin- -8-ylamine ##STR00614## 1-[3-(Benzo[1,2,5]oxadiazol-5-ylmethoxy)-phenyl]-3-cyclobutyl-imidazo[1,- 5-a]pyrazin-8-ylamine ##STR00615## 3-Cyclobutyl-1-[3-(3,4,5-trifluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyra- zin-8-ylamine ##STR00616## 3-Cyclobutyl-1-[3-(2-fluoro-5-trifluoromethyl-benzyloxy)-phenyl]-imidazo- [1,5-a]pyrazin-8-ylamine ##STR00617## 3-Cyclobutyl-1-[3-(4-difluoromethoxy-benzyloxy)-phenyl]-imidazo[1,5-a]py- razin-8-ylamine ##STR00618## 1-[3-(5-Chloro-benzo[b]thiophen-3-ylmethoxy)-phenyl]-3-cyclobutyl-imidaz- o[1,5-a]pyrazin-8-ylamine ##STR00619## 1-[3-(4-Chloro-2-fluoro-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]py- razin-8-ylamine ##STR00620## 3-Cyclobutyl-1-[3-(3,5-difluoro-benzyloxy)-phenyl]-imidazol[1,5-a]pyrazi- n-8-ylamine ##STR00621## 3-Cyclobutyl-1-[3-(2,6-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin- -8-ylamine ##STR00622## 3-Cyclobutyl-1-[3-(3-fluoro-benzyloxy)-phenyl]-imidazol[1,5-a]pyrazin-8-- ylamine ##STR00623## 3-Cyclobutyl-1-[3-(naphthalen-1-ylmethoxy)-phenyl]-imidazo[1,5-a]pyrazin- -8-ylamine ##STR00624## 3-Cyclobutyl-1-[3-(2,5-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin- -8-ylamine ##STR00625## 1-[3-(2-Chloro-6-fluoro-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]py- razin-8-ylamine ##STR00626## 3-Cyclobutyl-1-[3-(2,3,6-trifluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyra- zin-8-ylamine ##STR00627## 3-Cyclobutyl-1-[3-(2-fluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-y- lamine ##STR00628## 3-Cyclobutyl-1-[3-(2-difluoromethoxy-benzyloxy)-phenyl]-imidazo[1,5-a]py- razin-8-ylamine ##STR00629## 3-Cyclobutyl-1-[3-(3-difluoromethoxy-benzyloxy)-phenyl]-imidazo[1,5-a]py- razin-8-ylamine ##STR00630## 3-Cyclobutyl-1-[3-(quinolin-8-ylmethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8- -ylamine ##STR00631## 3-Cyclobutyl-1-[3-(1-phenyl-ethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylam- ine ##STR00632## 3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-be- nzoic acid ##STR00633## 3-Cyclobutyl-1-[3-(pyridin-2-ylmethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-- ylamine ##STR00634## 3-Cyclobutyl-1-[3-(3,5-dimethyl-isoxazol-4-ylmethoxy)-phenyl]-imidazo[1,- 5-a]pyrazin-8-ylamine ##STR00635## 3-Cyclobutyl-1-[3-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-phenyl]-imida- zo[1,5-a]pyrazin-8-ylamine

or a pharmaceutically acceptable salt thereof, wherein * is the point of attachment.

68. A compound selected from the group consisting of: TABLE-US-00017 ##STR00636## R1 Name ##STR00637## [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-isoprop- yl-amine ##STR00638## [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-ethyl-a- mine ##STR00639## Allyl-[1-(3-benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-a- mine ##STR00640## [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-prop-2-- ynyl-amine ##STR00641## [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-propyl-- amine ##STR00642## [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-cyclopr- opylmethyl-amine ##STR00643## Benzyl-[1-(3-benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-- amine ##STR00644## [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-phenyl-- amine ##STR00645## [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-methyl-- amine ##STR00646## [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-(2-meth- oxy-ethyl)-amine ##STR00647## 1-(3-Benzyloxy-phenyl)-3-cyclobutyl-8-morpholin-4-yl-imidazo[1,5-a]pyraz- ine ##STR00648## [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-diethyl- -amine ##STR00649## [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-(2-meth- oxy-ethyl)-amine

or a pharmaceutically acceptable salt thereof, wherein * is the point of attachment.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.