Claims for Patent: 7,459,554

Summary for Patent: 7,459,554

Title:	Imidazopyrazine tyrosine kinase inhibitors
Abstract:	Compounds of the formula and pharmaceutically acceptable salts thereof, wherein Q1 and R1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.
Inventor(s):	Han-Qing Dong, Kenneth Foreman, Mark Joseph Mulvihill, Anthony Innocenzo Nigro, Arno G. Steinig, Douglas Werner, Robin Wilkes
Assignee:	Acerta Pharma BV
Application Number:	US10/965,182
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 7,459,554
Patent Claims:	1. A compound represented by Formula I: or a pharmaceutically acceptable salt thereof, wherein: Q1 is aryl1, heteroaryl1, cycloalkyl, heterocyclyl, cycloalkenyl, or heterocycloalkenyl, any of which is optionally substituted by one to five independent G1 substituents; R1 is alkyl, cycloalkyl, bicycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclyl, or heterobicycloalkyl, any of which is optionally substituted by one or more independent G11 substituents; G1 and G41 are each independently halo, oxo, —CF3, —OCF3, —OR2, —NR2R3(R3a)j1, —C(O)R2, —CO2R2, —CONR2R3, —NO2, —CN, —S(O)j1R2, —SO2NR2R3, NR2(C═O)R3, NR2(C═O)OR3, NR2(C═O)NR2R3, NR2S(O)j1R3, —(C═S)OR2, —(C═O)SR2, —NR2(C═NR3)NR2aR3a, —NR2(C═NR3)OR2a, —NR2(C═NR3)SR3a, —O(C═O)OR2, —O(C═O)NR2R3, —O(C═O)SR2, —S(C═O)OR2, —S(C═O)NR2R3, C0-10alkyl, C2-10alkenyl, C2-10alkynyl, C1-10alkoxyC1-10alkyl, C1-10alkoxyC2-10alkenyl, C1-10alkoxyC2-10alkynyl, C1-10alkylthioC1-10alkyl, C1-10alkylthioC2-10alkenyl, C1-10alkylthioC2-10alkynyl, cycloC3-8alkyl, cycloC3-8alkenyl, cycloC3-8alkylC1-10alkyl, cycloC3-8alkenylC1-10alkyl, cycloC3-8alkylC2-10alkenyl, cycloC3-8alkenylC2-10alkenyl, cycloC3-8alkylC2-10alkynyl, cycloC3-8alkenylC2-10alkynyl, heterocyclyl-C0-10alkyl, heterocyclyl-C2-10alkenyl, or heterocyclyl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, oxo, —CF3, —OCF3, —OR222, —NR222R333(R333a)j1a, —C(O)R222, —CO2R222, —CONR222R333, —NO2, —CN, —S(O)j1aR222, —SO2NR222R333, NR222(C═O)R333, NR222(C═O)OR333, NR222(C═O)NR222R333, NR222S(O)j1aR333, —(C═S)OR222, —(C═O)SR222, —NR222(C═NR333)NR222aR333a, —NR222(C═NR333)OR222a, —NR222(C═NR333)SR333a, —O(C═O)OR222, —O(C═O)NR222R333, —O(C═O)SR222, —S(C═O)OR222, or —S(C═O)NR222R333 substituents; or —(X1)n—(Y1)m—R4; or aryl-C0-10alkyl, aryl-C2-10alkenyl, or aryl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, —CF3, —OCF3, —OR222, —NR222R333(R333a)j2a, —C(O)R222, —CO2R222, —CONR222R333, —NO2, —CN, —S(O)j2aR222, —SO2NR222R333, NR222(C═O)R333, NR222(C═O)OR333, NR222(C═O)NR222R333, NR222S(O)j2aR333, —(C═S)OR222, —(C═O)SR222, —NR222(C═NR333)NR222aR333a, —NR222(C═NR333)OR222a, —NR222(C═NR333)SR333a, —O(C═O)OR222, —O(C═O)NR222R333, —O(C═O)SR222, —S(C═O)OR222, or —S(C═O)NR222R333 substituents; or hetaryl-C0-10alkyl, hetaryl-C2-10alkenyl, or hetaryl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, —CF3, —OCF3, —OR222, —NR222R333(R333a)j3a, —C(O)R222, —CO2R222, —CONR222R333, —NO2, —CN, —S(O)j3aR222, —SO2NR222R333, NR222(C═O)R333, NR222(C═O)OR333, NR222(C═O)NR222R333, NR222S(O)j3aR333, —(C═S)OR222, —(C═O)SR222, —NR222(C═NR333)NR222aR333a, —NR222(C═NR333)OR222a, —NR222(C═NR333)SR333a, —O(C═O)OR222, —O(C═O)NR222R333, —O(C═O)SR222, —S(C═O)OR222, or —S(C═O)NR222R333 substituents; G11 is halo, oxo, —CF3, —OCF3, —OR21, —NR21R31(R3a1)j4, —C(O)R21, —CO2R21, —CONR21R31, —NO2, —CN, —S(O)j4R21, —SO2NR21R31, NR21(C═O)R31, NR21(C═O)OR31, NR21(C═O)NR21R31, NR21S(O)j4R31, —(C═S)OR21, —(C═O)SR21, —NR21 (C═NR31)NR2a1R3a1, —NR21(C═NR31)OR2a1, —NR21(C═NR31)SR3a1, —O(C═O)OR21, —O(C═O)NR21R31, —O(C═O)SR21, —S(C═O)OR21, —S(C═O)NR21R31, —P(O)OR21OR31, C0-10alkyl, C2-10alkenyl, C2-10alkynyl, C1-10alkoxyC1-10alkyl, C1-10alkoxyC2-10alkenyl, C1-10alkoxyC2-10alkynyl, C1-10alkylthioC1-10alkyl, C1-10alkylthioC2-10alkenyl, C1-10alkylthioC2-10alkynyl, cycloC3-8alkyl, cycloC3-8alkenyl, cycloC3-8alkylC1-10alkyl, cycloC3-8alkenylC1-10alkyl, cycloC3-8alkylC2-10alkenyl, cycloC3-8alkenylC2-10alkenyl, cycloC3-8alkylC2-10alkynyl, cycloC3-8alkenylC2-10alkynyl, heterocyclyl-C0-10alkyl, heterocyclyl-C2-10alkenyl, or heterocyclyl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, oxo, —CF3, —OCF3, —OR2221, —NR2221R3331(R333a1)j4a, —C(O)R2221, —CO2R2221, —CONR2221R3331, —NO2, —CN, —S(O)j4aR2221, —SO2NR2221R3331, NR2221(C═O)R3331, NR2221(C═O)OR3331, NR2221(C═O)NR2221R3331, NR2221S(O)j4aR3331, —(C═S)OR2221, —(C═O)SR2221, —NR2221(C═NR3331)NR222a1R333a1, —NR2221(C═NR3331)OR222a1, —NR2221(C═NR3331)SR333a1, —O(C═O)OR2221, —O(C═O)NR2221R3331, —O(C═O)SR2221, —S(C═O)OR2221, —P(O)OR2221OR3331, or —S(C═O)NR2221R3331 substituents; or aryl-C0-10alkyl, aryl-C2-10alkenyl, or aryl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, —CF3, —OCF3, —OR2221, —NR2221R3331(R333a1)j5a, —C(O)R2221, —CO2R2221, —CONR2221R3331, —NO2, —CN, —S(O)j5aR2221, —SO2NR2221R3331, NR2221(C═O)R3331, NR2221(C═O)OR3331, NR2221(C═O)NR2221R3331, NR2221S(O)j5aR3331, —(C═S)OR2221, —(C═O)SR2221, —NR2221(C═NR3331)NR222a1R333a1, —NR2221(C═NR3331)OR222a1, —NR2221(C═NR3331)SR333a1, —O(C═O)OR2221, —O(C═O)NR2221R3331, —O(C═O)SR2221, —S(C═O)OR2221, —P(O)OR2221R3331, or —S(C═O)NR2221R3331 substituents; or hetaryl-C0-10alkyl, hetaryl-C2-10alkenyl, or hetaryl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, —CF3, —OCF3, —OR2221, —NR2221R3331(R333a1)j6a, —C(O)R2221, —CO2R2221, —CONR2221R3331, —NO2, —CN, —S(O)j6aR2221, —SO2NR2221R3331, NR2221(C═O)R3331, NR2221(C═O)OR3331, NR2221(C═O)NR2221R3331, NR2221S(O)j6aR3331, —(C═S)OR2221, —(C═O)SR2221, —NR2221(C═NR3331)NR222a1R333a1, —NR2221(C═NR3331)OR222a1, —NR2221(C═NR3331)SR333a1, —O(C═O)OR2221, —O(C═O)NR2221R3331, —O(C═O)SR2221, —S(C═O)OR2221, —P(O)OR2221OR3331, or —S(C═O)NR2221R3331 substituents; or G11 is taken together with the carbon to which it is attached to form a double bond which is substituted with R5 and G111; R2, R2a, R3, R3a, R222, R222a, R333, R333a, R21, R2a1, R31, R3a1, R2221, R222a1, R3331, and R333a1 are each independently equal to C0-10alkyl, C2-10alkenyl, C2-10alkynyl, C1-10alkoxyC1-10alkyl, C1-10alkoxyC2-10alkenyl, C1-10alkoxyC2-10alkynyl, C1-10alkylthioC1-10alkyl, C1-10alkylthioC2-10alkenyl, C1-10alkylthioC2-10alkynyl, cycloC3-8alkyl, cycloC3-8alkenyl, cycloC3-8alkylC1-10alkyl, cycloC3-8alkenylC1-10alkyl, cycloC3-8alkylC2-10alkenyl, cycloC3-8alkenylC2-10alkenyl, cycloC3-8alkylC2-10alkynyl, cycloC3-8alkenylC2-10alkynyl, heterocyclyl-C0-10alkyl, heterocyclyl-C2-10alkenyl, or heterocyclyl-C2-10alkynyl, any of which is optionally substituted by one or more G111 substituents; or aryl-C0-10alkyl, aryl-C2-10alkenyl, or aryl-C2-10alkynyl, hetaryl-C0-10alkyl, hetaryl-C2-10alkenyl, or hetaryl-C2-10alkynyl, any of which is optionally substituted by one or more G111 substituents; or in the case of —NR2R3(R3a)j1 or —NR222R333(R333a)j1a or —NR222R333(R333a)j2a or —NR2221R3331(R333a1)j3a or —NR2221R3331(R333a1)j4a or —NR2221R3331(R333a1)j5a or —NR2221R3331(R333a1)j6a, R2 and R3 or R222 and R3333 or R2221 and R3331 taken together with the nitrogen atom to which they are attached form a 3-10 membered saturated ring, unsaturated ring, heterocyclic saturated ring, or heterocyclic unsaturated ring, wherein said ring is optionally substituted by one or more G111 substituents; X1 and Y1 are each independently —O—, —NR7—, —S(O)j7—, —CR5R6—, —N(C(O)OR7)—, —N(C(O)R7)—, —N(SO2R7)—, —CH2O—, —CH2S—, —CH2N(R7)—, —CH(NR7)—, —CH2N(C(O)R7)—, —CH2N(C(O)OR7)—, —CH2N(SO2R7)—, —CH(NHR7)—, —CH(NHC(O)R7)—, —CH(NHSO2R7)—, —CH(NHC(O)OR7)—, —CH(OC(O)R7)—, —CH(OC(O)NHR7)—, —CH═CH—, —C≡C—, —C(═NOR7)—, —C(O)—, —CH(OR7)—, —C(O)N(R7)—, —N(R7)C(O)—, —N(R7)S(O)—, —N(R7)S(O)2— —OC(O)N(R7)—, —N(R7)C(O)N(R7)—, —NR7C(O)O—, —S(O)N(R7)—, —S(O)2N(R7)—, —N(C(O)R7)S(O)—, —N(C(O)R7)S(O)2—, —N(R7)S(O)N(R7)—, —N(R7)S(O)2N(R7)—, —C(O)N(R7)C(O)—, —S(O)N(R7)C(O)—, —S(O)2N(R7)C(O)—, —OS(O)N(R7)—, —OS(O)2N(R7)—, —N(R7)S(O)O—, —N(R7)S(O)2O—, —N(R7)S(O)C(O)—, —N(R7)S(O)2C(O)—, —SON(C(O)R7)—, —SO2N(C(O)R7)—, —N(R7)SON(R7)—, —N(R7)SO2N(R7)—, —C(O)O—, —N(R7)P(OR8)O—, —N(R7)P(OR8)—, —N(R7)P(O)(OR8)O—, —N(R7)P(O)(OR8)—, —N(C(O)R7)P(OR8)O—, —N(C(O)R7)P(OR8)—, —N(C(O)R7)P(O)(OR8)O—, —N(C(O)R7)P(OR8)—, —CH(R7)S(O)—, —CH(R7)S(O)2—, —CH(R7)N(C(O)OR7)—, —CH(R7)N(C(O)R7)—, —CH(R7)N(SO2R7)—, —CH(R7)O—, —CH(R7)S—, —CH(R7)N(R7)—, —CH(R7)N(C(O)R7)—, —CH(R7)N(C(O)OR7)—, —CH(R7)N(SO2R7)—, —CH(R7)C(═NOR7)—, —CH(R7)C(O)—, —CH(R7)CH(OR7)—, —CH(R7)C(O)N(R7)—, —CH(R7)N(R7)C(O)—, —CH(R7)N(R7)S(O)—, —CH(R7)N(R7)S(O)2—, —CH(R7)OC(O)N(R7)—, —CH(R7)N(R7)C(O)N(R7)—, —CH(R7)NR7C(O)O—, —CH(R7)S(O)N(R7)—, —CH(R7)S(O)2N(R7)—, —CH(R7)N(C(O)R7)S(O)—, —CH(R7)N(C(O)R7)S(O)—, —CH(R7)N(R7)S(O)N(R7)—, —CH(R7)N(R7)S(O)2N(R7)—, —CH(R7)C(O)N(R7)C(O)—, —CH(R7)S(O)N(R7)C(O)—, —CH(R7)S(O)2N(R7)C(O)—, —CH(R7)OS(O)N(R7)—, —CH(R7)OS(O)2N(R7)—, —CH(R7)N(R7)S(O)O—, —CH(R7)N(R7)S(O)2O—, —CH(R7)N(R7)S(O)C(O)—, —CH(R7)N(R7)S(O)2C(O)—, —CH(R7)SON(C(O)R7)—, —CH(R7)SO2N(C(O)R7)—, —CH(R7)N(R7)SON(R7)—, —CH(R7)N(R7)SO2N(R7)—, —CH(R7)C(O)O—, —CH(R7)N(R7)P(OR8)O—, —CH(R7)N(R7)P(OR8)—, —CH(R7)N(R7)P(O)(OR8)O—, —CH(R7)N(R7)P(O)(OR8)—, —CH(R7)N(C(O)R7)P(OR8)O—, —CH(R7)N(C(O)R7)P(OR8)—, —CH(R7)N(C(O)R7)P(O)(OR8)O—, or —CH(R7)N(C(O)R7)P(OR8)—; or X1 and Y1 are each independently represented by one of the following structural formulas: R10, taken together with the phosphinamide or phosphonamide, is a 5-, 6-, or 7-membered aryl, heteroaryl or heterocyclyl ring system; R5, R6, and G111 are each independently a C0-10alkyl, C2-10alkenyl, C2-10alkynyl, C1-10alkoxyC1-10alkyl, C1-10alkoxyC2-10alkenyl, C1-10alkoxyC2-10alkynyl, C1-10alkylthioC1-10alkyl, C1-10alkylthioC2-10alkenyl, C1-10alkylthioC2-10alkynyl, cycloC3-8alkyl, cycloC3-8alkenyl, cycloC3-8alkylC1-10alkyl, cycloC3-8alkenylC1-10alkyl, cycloC3-8alkylC2-10alkenyl, cycloC3-8alkenylC2-10alkenyl, cycloC3-8alkylC2-10alkynyl, cycloC3-8alkenylC2-10alkynyl, heterocyclyl-C0-10alkyl, heterocyclyl-C2-10alkenyl, or heterocyclyl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, —CF3, —OCF3, —OR77, —NR77R87, —C(O)R77, —CO2R77, —CONR77R87, —NO2, —CN, —S(O)j5aR77, —SO2NR77R87, NR77(C═O)R87, NR77(C═O)OR87, NR77(C═O)NR78R87, NR77S(O)j5aR87, —(C═S)OR77, —(C═O)SR77, —NR77(C═NR87)NR78R88, —NR77(C═NR87)OR78, —NR77(C═NR87)SR78, —O(C═O)OR77, —O(C═O)NR77R87, —O(C═O)SR77, —S(C═O)OR77, —P(O)OR77OR87, or —S(C═O)NR77R87 substituents; or aryl-C0-10alkyl, aryl-C2-10alkenyl, or aryl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, —CF3, —OCF3, —OR77, —NR77R87, —C(O)R77, —CO2R77, —CONR77R87, —NO2, —CN, —S(O)j5aR77, —SO2NR77R87, NR77(C═O)R87, NR77(C═O)OR87, NR77(C═O)NR78R87, NR77S(O)j5aR87, —(C═S)OR77, —(C═O)SR77, —NR77(C═NR87)NR78R88, —NR77(C═NR87)OR78, —NR77(C═NR87)SR78, —O(C═O)OR77, —O(C═O)NR77R87, —O(C═O)SR77, —S(C═O)OR77, —P(O)OR77R87, or —S(C═O)NR77R87 substituents; or hetaryl-C0-10alkyl, hetaryl-C2-10alkenyl, or hetaryl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, —CF3, —OCF3, —OR77, —NR77R87, —C(O)R77, —CO2R77, —CONR77R87, —NO2, —CN, —S(O)j5aR77, —SO2NR77R87, NR77(C═O)R87, NR77(C═O)OR87, NR77(C═O)NR78R87, NR77S(O)j5aR87, —(C═S)OR77, —(C═O)SR77, —NR77(C═NR87)NR78R88, —NR77(C═NR87)OR78, —NR77(C═NR87)SR78, —O(C═O)OR77, —O(C═O)NR77R87, —O(C═O)SR77, —S(C═O)OR77, —P(O)OR77OR87, or —S(C═O)NR77R87 substituents; or R5 with R6 taken together with the respective carbon atom to which they are attached, form a 3-10 membered saturated or unsaturated ring, wherein said ring is optionally substituted with R69; or R5 with R6 taken together with the respective carbon atom to which they are attached, form a 3-10 membered saturated or unsaturated heterocyclic ring, wherein said ring is optionally substituted with R69; R7 and R8 are each independently H, acyl, alkyl, alkenyl, aryl, heteroaryl, heterocyclyl or cycloalkyl, any of which is optionally substituted by one or more G111 substituents; R4 is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, cycloalkenyl, or heterocycloalkenyl, any of which is optionally substituted by one or more G41 substituents; R69 is equal to halo, —OR78, —SH, —NR78R88, —CO2R78, —CONR78R88, —NO2, —CN, —S(O)j8R78, —SO2NR78R88, C0-10alkyl, C2-10alkenyl, C2-10alkynyl, C1-10alkoxyC1-10alkyl, C1-10alkoxyC2-10alkenyl, C1-10alkoxyC2-10alkynyl, C1-10alkylthioC1-10alkyl, C1-10alkylthioC2-10alkenyl, C1-10alkylthioC2-10alkynyl, cycloC3-8alkyl, cycloC3-8alkenyl, cycloC3-8alkylC1-10alkyl, cycloC3-8alkenylC1-10alkyl, cycloC3-8alkylC2-10alkenyl, cycloC3-8alkenylC2-10alkenyl, cycloC3-8alkylC2-10alkynyl, cycloC3-8alkenylC2-10alkynyl, heterocyclyl-C0-10alkyl, heterocyclyl-C2-10alkenyl, or heterocyclyl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, cyano, nitro, —OR778, —SO2NR778R888, or —NR778R888 substituents; or aryl-C0-10alkyl, aryl-C2-10alkenyl, or aryl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, cyano, nitro, —OR778, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, haloC1-10alkyl, haloC2-10alkenyl, haloC2-10alkynyl, —COOH, C1-4alkoxycarbonyl, —CONR778R888, —SO2NR778R888, or —NR778R888 substituents; or hetaryl-C0-10alkyl, hetaryl-C2-10alkenyl, or hetaryl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, cyano, nitro, —OR778, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, haloC1-10alkyl, haloC2-10alkenyl, haloC2-10alkynyl, —COOH, C1-4alkoxycarbonyl, —CONR778R888, —SO2NR778R888, or —NR778R888 substituents; or mono(C1-6alkyl)aminoC1-6alkyl, di(C1-6alkyl)aminoC1-6alkyl, mono(aryl)aminoC1-6alkyl, di(aryl)aminoC1-6alkyl, or —N(C1-6alkyl)-C1-6alkyl-aryl, any of which is optionally substituted with one or more independent halo, cyano, nitro, —OR778, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, haloC1-10alkyl, haloC2-10alkenyl, haloC2-10alkynyl, —COOH, C1-4alkoxycarbonyl, —CONR778R888 SO2NR778R888, or —NR778R888 substituents; or in the case of —NR78R88, R78 and R88 taken together with the nitrogen atom to which they are attached form a 3-10 membered saturated ring, unsaturated ring, heterocyclic saturated ring, or heterocyclic unsaturated ring, wherein said ring is optionally substituted with one or more independent halo, cyano, hydroxy, nitro, C1-10alkoxy, —SO2NR778R888, or —NR778R888 substituents; R77, R78, R87, R88, R778, and R888 are each independently C0-10alkyl, C2-10alkenyl, C2-10alkynyl, C1-10alkoxyC1-10alkyl, C1-10alkoxyC2-10alkenyl, C1-10alkoxyC2-10alkynyl, C1-10alkylthioC1-10alkyl, C1-10alkylthioC2-10alkenyl, C1-10alkylthioC2-10alkynyl, cycloC3-8alkyl, cycloC3-8alkenyl, cycloC3-8alkylC1-10alkyl, cycloC3-8alkenylC1-10alkyl, cycloC3-8alkylC2-10alkenyl, cycloC3-8alkenylC2-10alkenyl, cycloC3-8alkylC2-10alkynyl, cycloC3-8alkenylC2-10alkynyl, heterocyclyl-C0-10alkyl, heterocyclyl-C2-10alkenyl, heterocyclyl-C2-10alkynyl, C1-10alkylcarbonyl, C2-10alkenylcarbonyl, C2-10alkynylcarbonyl, C1-10alkoxycarbonyl, C1-10alkoxycarbonylC1-10alkyl, monoC1-6alkylaminocarbonyl, diC1-6alkylaminocarbonyl, mono(aryl)aminocarbonyl, di(aryl)aminocarbonyl, or C1-10alkyl(aryl)aminocarbonyl, any of which is optionally substituted with one or more independent halo, cyano, hydroxy, nitro, C1-10alkoxy, —SO2N(C0-4alkyl)(C0-4alkyl), or —N(C0-4alkyl)(C0-4alkyl) substituents; or aryl-C0-10alkyl, aryl-C2-10alkenyl, or aryl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, cyano, nitro, —O(C0-4alkyl), C1-10alkyl, C2-10alkenyl, C2-10alkynyl, haloC1-10alkyl, haloC2-10alkenyl, haloC2-10alkynyl, —COOH, C1-4alkoxycarbonyl, —CON(C0-4alkyl)(C0-10alkyl), —SO2N(C0-4alkyl)(C0-4alkyl), or —N(C0-4alkyl)(C0-4alkyl) substituents; or hetaryl-C0-10alkyl, hetaryl-C2-10alkenyl, or hetaryl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, cyano, nitro, —O(C0-4alkyl), C1-10alkyl, C2-10alkenyl, C2-10alkynyl, haloC1-10alkyl, haloC2-10alkenyl, haloC2-10alkynyl, —COOH, C1-4alkoxycarbonyl, —CON(C0-4alkyl)(C0-4alkyl), —SO2N(C0-4alkyl)(C0-4alkyl), or —N(C0-4alkyl)(C0-4alkyl) substituents; or mono(C1-6alkyl)aminoC1-6alkyl, di(C1-6alkyl)aminoC1-6alkyl, mono(aryl)aminoC1-6alkyl, di(aryl)aminoC1-6alkyl, or —N(C1-6alkyl)-C1-6alkyl-aryl, any of which is optionally substituted with one or more independent halo, cyano, nitro, —O(C0-4alkyl), C1-10alkyl, C2-10alkenyl, C2-10alkynyl, haloC1-10alkyl, haloC2-10alkenyl, haloC2-10alkynyl, —COOH, C1-4alkoxycarbonyl, —CON(C0-4alkyl)(C0-4alkyl), —SO2N(C0-4alkyl)(C0-4alkyl), or —N(C0-4alkyl)(C0-4alkyl) substituents; and n, m, j1, j1a, j2a, j3a, j4, j4a, j5a, j6a, j7, and j8 are each independently equal to 0, 1, or 2. 2. The compound or salt of claim 1, wherein Q1 is aryl1 or heteroaryl1, any of which is optionally substituted by one or more independent G1 substituents. 3. The compound or salt of claim 2, wherein Q1 is heteroaryl1, any of which is optionally substituted by one or more independent G1 substituents. 4. The compound or salt of claim 3, wherein Q1 is aryl1, any of which is optionally substituted by one or more independent G1 substituents. 5. The compound or salt of claim 1, wherein G1 is halo, —CF3, —OCF3, —OR2, —NR2R3, —C(O)R2, —CO2R2, —CONR2R3, —S(O)j1R2, —SO2NR2R3, NR2(C═O)R3, NR2(C═O)OR3, NR2(C═O)NR2R3, NR2S(O)j1R3, —O(C═O)OR2, —O(C═O)NR2R3, C0-10alkyl, C2-10alkenyl, C2-10alkynyl, C1-10alkoxyC1-10alkyl, C1-10alkoxyC2-10alkenyl, C1-10alkoxyC2-10alkynyl, C1-10alkylthioC1-10alkyl, C1-10alkylthioC2-10alkenyl, C1-10alkylthioC2-10alkynyl, cycloC3-8alkyl, cycloC3-8alkenyl, cycloC3-8alkylC1-10alkyl, cycloC3-8alkenylC1-10alkyl, cycloC3-8alkylC2-10alkenyl, cycloC3-8alkenylC2-10alkenyl, cycloC3-8alkylC2-10alkynyl, cycloC3-8alkenylC2-10alkynyl, heterocyclyl-C0-10alkyl, heterocyclyl-C2-10alkenyl, or heterocyclyl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, oxo, —CF3, —OCF3, —OR222, —NR222R333(R333a)j1a, —C(O)R222, —CO2R222, —CONR222R333, —NO2, —CN, —S(O)j1aR222, —SO2NR222R333, NR222(C═O)R333, NR222(C═O)OR333, NR222(C═O)NR222R333, NR222S(O)j1aR333, —(C═S)OR222, —(C═O)SR222, —NR222(C═NR333)NR222aR333a, —NR222(C═NR333)OR222a, —NR222(C═NR333)SR333a, —O(C═O)OR222, —O(C═O)NR222R333, —O(C═O)SR222, —S(C═O)OR222, or —S(C═O)NR222R333 substituents; or —(X1)n—(Y1)m—R4; or aryl-C0-10alkyl, aryl-C2-10alkenyl, or aryl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, —CF3, —OCF3, —OR222, —NR222R333(R333a)j2a, —C(O)R222, —CO2R222, —CONR222R333, —NO2, —CN, —S(O)j2aR222, —SO2NR222R333, NR222(C═O)R333, NR222(C═O)OR333, NR222(C═O)NR222R333, NR222S(O)j2aR333, —(C═S)OR222, —(C═O)SR222, —NR222(C═NR333)NR222aR333a, —NR222(C═NR333)OR222a, —NR222(C═NR333)SR333a, —O(C═O)OR222, —O(C═O)NR222R333, —O(C═O)SR222, —S(C═O)OR222, or —S(C═O)NR222R333 substituents; or hetaryl-C0-10alkyl, hetaryl-C2-10alkenyl, or hetaryl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, —CF3, —OCF3, —OR222, —NR222R333(R333a)j3a, —C(O)R222, —CO2R222, —CONR222R333, —NO2, —CN, —S(O)j3aR222, —SO2NR222R333, NR222(C═O)R333, NR222 (C═O)OR333, NR222(C═O)NR222R333, NR222S(O)j3aR333, —(C═S)OR222, —(C═O)SR222, —NR222(C═NR333)NR222aR333a, —NR222(C═NR333)OR222a, —NR222(C═NR333)SR333a, —O(C═O)OR222, —O(C═O)NR222R333, —O(C═O)SR222, —S(C═O)OR222, or —S(C═O)NR222R333 substituents. 6. The compound or salt of claim 1, wherein G1 is halo, —OR2, —NR2R3, —C(O)R2, —CO2R2, —CONR2R3, —SO2NR2R3, NR2(C═O)R3, NR2(C═O)OR3, NR2(C═O)NR2R3, NR2S(O)j1R3, —O(C═O)OR2, —O(C═O)NR2R3, C0-10alkyl, C2-10alkenyl, C1-10alkoxyC1-10alkyl, C1-10alkoxyC2-10alkenyl, C1-10alkylthioC1-10alkyl, C1-10alkylthioC2-10alkenyl, cycloC3-8alkyl, cycloC3-8alkenyl, cycloC3-8alkylC1-10alkyl, cycloC3-8alkenylC1-10alkyl, cycloC3-8alkylC2-10alkenyl, cycloC3-8alkenylC2-10alkenyl, or heterocyclyl-C0-10alkyl, or heterocyclyl-C2-10alkenyl, any of which is optionally substituted with one or more independent oxo, —CF3, —OCF3, —OR222, —NR222R333, —C(O)R222, —CO2R222, —CONR222R333, —SO2NR222R333, NR222(C═O)R333, NR222(C═O)OR333, NR222(C═O)NR222R333, NR22S(O)j1aR333, —NR222(C═NR333)NR222aR333a, or —O(C═O)NR222R333 substituents; or —(X1)n—(Y1)m—R4; or aryl-C0-10alkyl optionally substituted with one or more independent halo, —CF3, —OCF3, —OR222, —NR222R333, —C(O)R222, —CO2R222, —CONR222R333, —SO2NR222R333, NR222(C═O)R333, NR222(C═O)OR333, NR222(C═O)NR222R333, NR222S(O)j2aR333, —NR222(C═NR333)NR222aR333a, or —O(C═O)NR222R333 substituents; or hetaryl-C0-10alkyl, optionally substituted with one or more independent halo, —CF3, —OCF3, —OR222, —NR222R333, —C(O)R222, —CO2R222, —CONR222R333, —SO2NR222R333, NR222(C═O)R333, NR222(C═O)OR333, NR222(C═O)NR222R333, NR222S(O)j3aR333, —NR222(C═NR333)NR222aR333a, or —O(C═O)NR222R333 substituents. 7. The compound or salt of claim 1, wherein G1 is halo, —OR2, —NR2R3, —C(O)R2, —CO2R2, —CONR2R3, —SO2NR2R3, NR2(C═O)R3, NR2(C═O)OR3, NR2(C═O)NR2R3, NR2S(O)j1R3, —O(C═O)OR2, —O(C═O)NR2R3, C0-10alkyl, C2-10alkenyl, C1-10alkoxyC1-10alkyl, C1-10alkylthioC1-10alkyl, cycloC3-8alkyl, cycloC3-8alkenyl, or heterocyclyl-C0-10alkyl, or heterocyclyl-C2-10alkenyl, any of which is optionally substituted with one or more independent oxo, —CF3, —OCF3, —OR222, —NR222R333, —C(O)R222, —CO2R222, —CONR222R333, —SO2NR222R333, NR222(C═O)R333, NR222(C═O)OR333, NR222(C═O)NR222R333, NR222S(O)j1aR333, —NR222(C═NR333)NR222aR333a, or —O(C═O)NR222R333 substituents; or —(X1)n—(Y1)m—R4; or aryl-C0-10alkyl, optionally substituted with one or more independent halo, —CF3, —OCF3, —OR222, —NR222R333, —C(O)R222, —CO2R222, —CONR222R333, —SO2NR222R333, NR222(C═O)R333, NR222(C═O)OR333, NR222(C═O)NR222R333, NR222S(O)j2aR333, —NR222(C═NR333)NR222aR333a, or —O(C═O)NR222R333 substituents; or hetaryl-C0-10alkyl, optionally substituted with one or more independent halo, —CF3, —OCF3, —OR222, —NR222R333, —C(O)R222, —CO2R222, —CONR222R333, —SO2NR222R333, NR222(C═O)R333, NR222(C═O)OR333, NR222(C═O)NR222R333, NR222S(O)j3aR333, —NR222(C═NR333)NR222aR333a, or —O(C═O)NR222R333 substituents. 8. The compound or salt of claim 1, wherein G1 is halo, —OR2, —NR2R3, —C(O)R2, —CO2R2, —CONR2R3, —SO2NR2R3, NR2(C═O)R3, NR2(C═O)OR3, NR2(C═O)NR2R3, NR2S(O)j1R3, —O(C═O)OR2, —O(C═O)NR2R3, C0-10alkyl, C2-10alkenyl, C1-10alkoxyC1-10alkyl, C1-10alkylthioC1-10alkyl, cycloC3-8alkyl, cycloC3-8alkenyl, or heterocyclyl-C0-10alkyl, or heterocyclyl-C2-10alkenyl, any of which is optionally substituted with one or more independent oxo, —CF3, —OCF3, —OR222, —NR222R333, —C(O)R222, —CO2R222, —CONR222R333, —SO2 NR222R333, NR222(C═O)R333, NR222(C═O)OR333, NR222(C═O)NR222R333, NR222S(O)j1aR333, —NR222(C═NR333)NR222aR333a, or —O(C═O)NR222R333 substituents; or —(X1)n—(Y1)m—R4. 9. The compound or salt of claim 1, wherein X1 and Y1 are each independently —O—, —NR7—, —S(O)j7—, —CR5R6—, —N(C(O)OR7)—, —N(C(O)R7)—, —N(SO2R7)—, —CH2O—, —CH2S—, —CH2N(R7)—, —CH(NR7)—, —CH2N(C(O)R7)—, —CH2N(C(O)OR7)—, —CH2N(SO2R7)—, —CH(NHR7)—, —CH(NHC(O)R7)—, —CH(NHSO2R7)—, —CH(NHC(O)OR7)—, —CH(OC(O)R7)—, —CH(OC(O)NHR7)—, —C(O)—, —CH(OR7)—, —C(O)N(R7)—, —N(R7)C(O)—, —N(R7)S(O)—, —N(R7)S(O)2— —OC(O)N(R7)—, —N(R7)C(O)N(R7)—, —NR7C(O)O—, —S(O)N(R7)—, —S(O)2N(R7)—, —N(C(O)R7)S(O)—, —N(C(O)R7)S(O)2—, —N(R7)S(O)N(R7)—, —N(R7)S(O)2N(R7)—, —C(O)N(R7)C(O)—, —S(O)N(R7)C(O)—, —S(O)2N(R7)C(O)—, —OS(O)N(R7)—, —OS(O)2N(R7)—, —N(R7)S(O)O—, —N(R7)S(O)2O—, —N(R7)S(O)C(O)—, —N(R7)S(O)2C(O)—, —SON(C(O)R7)—, —SO2N(C(O)R7)—, —N(R7)SON(R7)—, —N(R7)SO2N(R7)—, —C(O)O—, —CH(R7)S(O)—, —CH(R7)S(O)2—, —CH(R7)N(C(O)OR7)—, —CH(R7)N(C(O)R7)—, —CH(R7)N(SO2R7)—, —CH(R7)O—, —CH(R7)S—, —CH(R7)N(R7)—, —CH(R7)N(C(O)R7)—, —CH(R7)N(C(O)OR7)—, —CH(R7)N(SO2R7)—, —CH(R7)C(═NOR7)—, —CH(R7)C(O)—, —CH(R7)CH(OR7)—, —CH(R7)C(O)N(R7)—, —CH(R7)N(R7)C(O)—, —CH(R7)N(R7)S(O)—, —CH(R7)N(R7)S(O)2—, —CH(R7)OC(O)N(R7)—, —CH(R7)N(R7)C(O)N(R7)—, —CH(R7)NR7C(O)O—, —CH(R7)S(O)N(R7)—, —CH(R7)S(O)2N(R7)—, —CH(R7)N(C(O)R7)S(O)—, —CH(R7)N(C(O)R7)S(O)—, —CH(R7)N(R7)S(O)N(R7)—, —CH(R7)N(R7)S(O)2N(R7)—, —CH(R7)C(O)N(R7)C(O)—, —CH(R7)S(O)N(R7)C(O)—, —CH(R7)S(O)2N(R7)C(O)—, —CH(R7)OS(O)N(R7)—, —CH(R7)OS(O)2N(R7)—, —CH(R7)N(R7)S(O)O—, —CH(R7)N(R7)S(O)2O—, —CH(R7)N(R7)S(O)C(O)—, —CH(R7)N(R7)S(O)2C(O)—, —CH(R7)SON(C(O)R7)—, —CH(R7)SO2N(C(O)R7)—, —CH(R7)N(R7)SON(R7)—, —CH(R7)N(R7)SO2N(R7)—, or —CH(R7)C(O)O—. 10. The compound or salt of claim 1 wherein Q1 is substituted by said one to five independent G1 substituents wherein at least one of said G1 substituents is —(X1)n—(Y1)m—R4, and wherein X1 and Y1 are each independently equal to —O—, —NR7—, —CR5R6—, —S(O)j7—, or —C(O)—, and wherein n and m are both equal to 1 and j7 is equal to 1 or 2. 11. The compound or salt of claim 1 wherein Q1 is substituted by said one to five independent G1 substituents wherein at least one of said G1 substituents is —(X1)n—(Y1)m—R4, and wherein X1 and Y1 are each independently —O— or —CR5R6—, and wherein n and m are equal to 1. 12. The compound or salt of claim 1 wherein R1 is cycloalkyl, bicycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclyl, or heterobicycloalkyl, any of which is optionally substituted by one or more independent G11 substituents. 13. The compound or salt of claim 1 wherein R1 is cycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, or heterocyclyl, any of which is optionally substituted by one or more independent G11 substituents. 14. The compound or salt of claim 1 wherein R1 is cycloalkyl or heterocyclyl, any of which is optionally substituted by one or more independent G11 substituents. 15. The compound or salt of claim 1 wherein R1 is cycloalkyl optionally substituted by one or more independent G11 substituents. 16. The compound or salt of claim 1 wherein R1 is heterocyclyl optionally substituted by one or more independent G11 substituents. 17. The compound or salt of claim 1 wherein R1 is aryl, heteroaryl, aralkyl, or heteroaralkyl, any of which is optionally substituted by one or more independent G11 substituents. 18. The compound or salt of claim 1 wherein R1 is aryl or heteroaryl, any of which is optionally substituted by one or more independent G11 substituents. 19. The compound or salt of claim 1 wherein G11 is —OR21, —NR21R31(R31a)j4, —C(O)R21, —CO2R21, —CONR21R31, NR21(C═O)R31, NR21(C═O)OR31, NR21(C═O)NR21R31, NR21S(O)j4R31, —O(C═O)OR21, —O(C═O)NR21R31, C0-10alkyl, cycloC3-8alkyl, cycloC3-8alkenyl, heterocyclyl-C0-10alkyl, or heterocyclyl-C2-10alkenyl, any of which is optionally substituted with one or more independent halo, oxo, —CF3, —OCF3, —OR2221, —NR2221R3331(R333a)j4a, —C(O)R2221, —CO2R2221, —CONR2221R3331, —NO2, —CN, —S(O)j4aR2221, —SO2NR2221R3331, NR2221(C═O)R3331, NR2221(C═O)OR3331, NR2221(C═O)NR2221R3331, NR2221S(O)j4aR3331, —(C═S)OR2221, —(C═O)SR2221, —NR2221(C═NR3331)NR222a1R333a1, —NR2221(C═NR3331)OR222a1, —NR2221(C═NR3331)SR333a1, —O(C═O)OR2221, —O(C═O)NR2221R3331, —O(C═O)SR2221, —S(C═O)OR2221, or —S(C═O)NR2221R3331 substituents; or aryl-C0-10alkyl, aryl-C2-10alkenyl, or aryl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, —CF3, —OCF3, —OR2221, —NR2221R3331(R333a1)j5a, —C(O)R2221, —CO2R2221, —CONR2221R3331, —NO2, —CN, —S(O)j5aR2221, —SO2NR2221R3331, NR2221(C═O)R3331, NR2221(C═O)OR3331, NR2221(C═O)NR2221R3331, NR2221S(O)j5aR3331, —(C═S)OR2221, —(C═O)SR2221, —NR2221(C═NR3331)NR222a1R333a1, —NR2221(C═NR3331)OR222a1, —NR2221(C═NR3331)SR333a1, —O(C═O)OR2221, —O(C═O)NR2221R3331, —O(C═O)SR2221, —S(C═O)OR2221, or —S(C═O)NR2221R3331 substituents; or hetaryl-C0-10alkyl, hetaryl-C2-10alkenyl, or hetaryl-C2-10alkynyl, any of which is optionally substituted with one or more independent halo, —CF3, —OCF3, —OR2221, —NR2221R3331(R333a1)j6a, —C(O)R2221, —CO2R2221, —CONR2221R3331, —NO2, —CN, —S(O)j6aR2221, —SO2NR2221R3331, NR2221(C═O)R3331, NR2221(C═O)OR3331, NR2221(C═O)NR2221R3331, NR2221S(O)j6aR3331, —(C═S)OR2221, —(C═O)SR2221, —NR2221(C═NR3331)NR222a1R333a1, —NR2221(C═NR3331)OR222a1, —NR2221(C═NR3331)SR333a1, —O(C═O)OR2221, —O(C═O)NR2221R3331, —O(C═O)SR2221, —S(C═O)OR2221, or —S(C═O)NR2221R3331 substituents. 20. The compound or salt of claim 1 wherein G11 is —OR21, —NR21R31, —CO2R21, —C(O)R21, —CONR21R31, NR21(C═O)R31, NR21(C═O)OR31, NR21(C═O)NR21R31, NR21S(O)j4R31, —O(C═O)OR21, —O(C═O)NR21R31, C0-10alkyl, cycloC3-8alkyl, cycloC3-8alkenyl, heterocyclyl-C0-10alkyl, or heterocyclyl-C2-10alkenyl, any of which is optionally substituted with one or more independent halo, oxo, —CF3, —OCF3, —OR2221, —NR2221R3331(R333a1)j4a, —C(O)R2221, —CO2R2221, —CONR2221R3331, —NO2, —CN, —S(O)j4aR2221, —SO2NR2221R3331, NR2221(C═O)R3331, NR2221(C═O)OR3331, NR2221(C═O)NR2221R3331, NR2221S(O)j4aR3331, —(C═S)OR2221, —(C═O)SR2221, —NR2221(C═NR3331)NR222a1R333a1, —NR2221(C═NR3331)OR222a1, —NR2221(C═NR3331)SR333a1, —O(C═O)OR2221, —O(C═O)NR2221R3331, —O(C═O)SR2221, —S(C═O)OR2221, or —S(C═O)NR2221R3331 substituents. 21. The compound or salt of claim 1 wherein R4 is H, alkyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, cycloalkenyl, or heterocycloalkenyl, any of which is optionally substituted by one or more independent G41 substituents. 22. The compound or salt of claim 10 wherein R4 is alkyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, cycloalkenyl, or heterocycloalkenyl, any of which is optionally substituted by one or more independent G41 substituents. 23. The compound or salt of claim 11 wherein R4 is alkyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, cycloalkenyl, or heterocycloalkenyl, any of which is optionally substituted by one or more independent G41 substituents. 24. The compound or salt of claim 1 wherein Q1 is phenyl substituted by said one to five independent G1 substituents wherein at least one of said G1 substituents is —(X1)n—(Y1)m—R4, and wherein n=1 and X1 is 3-(—O—), m=1 and Y1 is —(—CH2—), and R4 is aryl optionally substituted by one or more independent G41 substituents. 25. The compound or salt of claim 24 wherein R1 is aryl, heteroaryl, cycloalkyl or heterocyclyl, optionally substituted by one or more independent G11 substituents. 26. The compound or salt of claim 25 wherein R1 is cycloalkyl or heterocyclyl, optionally substituted by one or more independent G11 substituents. 27. The compound or salt of claim 26 wherein R1 is cycloalkyl, optionally substituted by one or more independent G11 substituents. 28. The compound or salt of claim 27 wherein R1 is cyclobutyl, cyclopentyl or cyclohexyl, optionally substituted by one or more independent G11 substituents. 29. The compound or salt of claim 27 wherein G11 is —OR21, —NR21R31, —CO2R21, —C(O)R21, —CONR21R31, NR21(C═O)R31, NR21(C═O)OR31, NR21(C═O)NR21R31, NR21S(O)j4R31, —O(C═O)OR21, —O(C═O)NR21R31, C0-10alkyl, cycloC3-8alkyl, cycloC3-8alkenyl, heterocyclyl-C0-10alkyl, or heterocyclyl-C2-10alkenyl, any of which is optionally substituted with one or more independent halo, oxo, —CF3, —OCF3, —OR2221, —NR2221R3331(R333a1)j4a, —C(O)R2221, —CO2R2221, —CONR2221R3331, —NO2, —CN, —S(O)j4aR2221, —SO2NR2221R3331, NR2221(C═O)R3331, NR2221(C═O)OR3331, NR2221(C═O)NR2221R3331, NR2221S(O)j4aR3331, —(C═S)OR2221, —(C═O)SR2221, —NR2221(C═NR3331)NR222a1R333a1, —NR2221(C═NR3331)OR222a1, —NR2221(C═NR3331)SR333a1, —O(C═O)OR2221, —O(C═O)NR2221R3331, —O(C═O)SR2221, —S(C═O)OR2221, or —S(C═O)NR2221R3331 substituents. 30. The compound or salt of claim 1 wherein Q1 is phenyl substituted by said one to five independent G1 substituents wherein at least one of said G1 substituents is —(X1)n—(Y1)m—R4, and wherein n=1 and X1 is 4-(—O—), m=1 and Y1 is —(—CH2—), and R4 is aryl optionally substituted by one or more independent G41 substituents. 31. The compound or salt of claim 30 wherein R1 is aryl, heteroaryl, cycloalkyl or heterocyclyl, optionally substituted by one or more independent G11 substituents. 32. The compound or salt of claim 31 wherein R1 is cycloalkyl or heterocyclyl, optionally substituted by one or more independent G11 substituents. 33. The compound or salt of claim 32 wherein R1 is cycloalkyl, optionally substituted by one or more independent G11 substituents. 34. The compound or salt of claim 33 wherein R1 is cyclobutyl, cyclopentyl or cyclohexyl, optionally substituted by one or more independent G11 substituents. 35. The compound or salt of claim 33 wherein G11 is —OR21, —NR21R31, —CO2R21, —C(O)R21, —CONR21R31, NR21(C═O)R31, NR21(C═O)OR31, NR21(C═O)NR21R31, NR21S(O)j4R31, —O(C═O)OR21, —O(C═O)NR21R31, C0-10alkyl, cycloC3-8alkyl, cycloC3-8alkenyl, heterocyclyl-C0-10alkyl, or heterocyclyl-C2-10alkenyl, any of which is optionally substituted with one or more independent halo, oxo, —CF3, —OCF3, —OR2221, —NR2221R3331(R333a1)j4a, —C(O)R2221, —CO2R2221, —CONR2221R3331, —NO2, —CN, —S(O)j4aR2221, —SO2NR2221R3331, NR2221(C═O)R3331, NR2221(C═O)OR3331, NR2221(C═O)NR2221R3331, NR2221S(O)j4aR3331, —(C═S)OR2221, —(C═O)SR2221, —NR2221(C═NR3331)NR222a1R333a1, —NR2221(C═NR3331)OR222a1, —NR2221(C═NR3331)SR333a1, —O(C═O)OR2221, —O(C═O)NR2221R3331, —O(C═O)SR2221, —S(C═O)OR2221, or —S(C═O)NR2221R3331 substituents. 36. The compound or salt of claim 1 wherein Q1 is phenyl substituted by said one to five independent G1 substituents wherein at least one of said G1 substituents is —(X1)n—(Y1)m—R4, and wherein n=1 and X1 is 3-(—O—), m=0, and R4 is (C0-C8)alkyl or cycloalkyl optionally substituted by one or more independent G41 substituents. 37. The compound or salt of claim 36 wherein R1 is aryl, heteroaryl, cycloalkyl or heterocyclyl, optionally substituted by one or more independent G11 substituents. 38. The compound or salt of claim 37 wherein R1 is cycloalkyl or heterocyclyl, optionally substituted by one or more independent G11 substituents. 39. The compound or salt of claim 38 wherein R1 is cycloalkyl, optionally substituted by one or more independent G11 substituents. 40. The compound or salt of claim 39 wherein R1 is cyclobutyl, cyclopentyl or cyclohexyl, optionally substituted by one or more independent G11 substituents. 41. The compound or salt of claim 39 wherein G11 is —OR21, —NR21R31, —CO2R21, —C(O)R21, —CONR21R31, NR21(C═O)R31, NR21(C═O)OR31, NR21(C═O)NR21R31, NR21S(O)j4R31, —O(C═O)OR21, —O(C═O)NR21R31, C0-10alkyl, cycloC3-8alkyl, cycloC3-8alkenyl, heterocyclyl-C0-10alkyl, or heterocyclyl-C2-10alkenyl, any of which is optionally substituted with one or more independent halo, oxo, —CF3, —OCF3, —OR2221, —NR2221R3331(R333a1)j4a, —C(O)R2221, —CO2R2221, —CONR2221R3331, —NO2, —CN, —S(O)j4aR2221, —SO2NR2221R3331, NR2221(C═O)R3331, NR2221(C═O)OR3331, NR2221(C═O)NR2221R3331, NR2221S(O)j4aR3331, —(C═S)OR2221, —(C═O)SR2221, —NR2221(C═NR3331)NR222a1R333a1, —NR2221(C═NR3331)OR222a1, —NR2221(C═NR3331)SR333a1, —O(C═O)OR2221, —O(C═O)NR2221R3331, —O(C═O)SR2221, —S(C═O)OR2221, or —S(C═O)NR2221R3331 substituents. 42. The compound or salt of claim 36 wherein R4 is (C0-C6)alkyl. 43. The compound or salt of claim 41 wherein R4 is (C0-C6)alkyl. 44. The compounds or salts of claim 36 wherein R4 is H or methyl. 45. The compound or salt of claim 43 wherein R4 is H or methyl. 46. The compound or salt of claim 1 wherein Q1 is phenyl substituted by said one to five independent G1 substituents wherein at least one of said G1 substituents is —(X1)n—(Y1)m—R4, and wherein n=1 and X1 is 3-(—O—), m=0, and R4 is aryl optionally substituted by one or more independent G41 substituents. 47. The compound or salt of claim 46 wherein R1 is aryl, heteroaryl, cycloalkyl or heterocyclyl, optionally substituted by one or more independent G11 substituents. 48. The compound or salt of claim 46 wherein R1 is cycloalkyl or heterocyclyl, optionally substituted by one or more independent G11 substituents. 49. The compound or salt of claim 48 wherein R1 is cyclobutyl, cyclopentyl or cyclohexyl, optionally substituted by one or more independent G11 substituents. 50. The compound or salt of claim 48 wherein G11 is —OR21, —NR21R31, —CO2R21, —C(O)R21, —CONR21R31, NR21(C═O)R31, NR21(C═O)OR31, NR21(C═O)NR21R31, NR21S(O)j4R31, —O(C═O)OR21, —O(C═O)NR21R31, C0-10alkyl, cycloC3-8alkyl, cycloC3-8alkenyl, heterocyclyl-C0-10alkyl, or heterocyclyl-C2-10alkenyl, any of which is optionally substituted with one or more independent halo, oxo, —CF3, —OCF3, —OR2221, —NR2221R3331(R333a1)j4a, —C(O)R2221, —CO2R2221, —CONR2221R3331, —NO2, —CN, —S(O)j4aR2221, —SO2NR2221R3331, NR2221(C═O)R3331, NR2221(C═O)OR3331, NR2221(C═O)NR2221R3331, NR2221S(O)j4aR3331, —(C═S)OR2221, —(C═O)SR2221, —NR2221(C═NR3331)NR222a1R333a1, —NR2221(C═NR3331)OR222a1, —NR2221(C═NR3331)SR333a1, —O(C═O)OR2221, —O(C═O)NR2221R3331, —O(C═O)SR2221, —S(C═O)OR2221, or —S(C═O)NR2221R3331 substituents. 51. The compound or salt of claim 46 wherein R4 is phenyl optionally substituted with G41. 52. The compound or salt of claim 1 wherein Q1 is phenyl substituted by said one to five independent G1 substituents wherein at least one of said G1 substituents is —(X1)n—(Y1)m—R4, and wherein n=1 and X1 is 3- or 4-(—NH—), m=1 and Y1 is —(—SO2—), and R4 is aryl optionally substituted by one or more independent G41 substituents. 53. The compound or salt of claim 52 wherein R1 is aryl, heteroaryl, cycloalkyl or heterocyclyl, optionally substituted by one or more independent G11 substituents. 54. The compound or salt of claim 53 wherein R1 is cycloalkyl or heterocyclyl, optionally substituted by one or more independent G11 substituents. 55. The compound or salt of claim 54 wherein R1 is cyclobutyl, cyclopentyl or cyclohexyl, optionally substituted by one or more independent G11 substituents. 56. The compound or salt of claim 54 wherein G11 is —OR21, —NR21R31, —CO2R21, —C(O)R21, —CONR21R31, NR21(C═O)R31, NR21(C═O)OR31, NR21(C═O)NR21R31, NR21S(O)j4R31, —O(C═O)OR21, —O(C═O)NR21R31, C0-10alkyl, cycloC3-8alkyl, cycloC3-8alkenyl, heterocyclyl-C0-10alkyl, or heterocyclyl-C2-10alkenyl, any of which is optionally substituted with one or more independent halo, oxo, —CF3, —OCF3, —OR2221, —NR2221R3331(R333a1)j4a, —C(O)R2221, —CO2R2221, —CONR2221R3331, —NO2, —CN, —S(O)j4aR2221, —SO2NR2221R3331, NR2221(C═O)R3331, NR2221(C═O)R3331, NR2221(C═O)NR2221R3331, NR2221S(O)j4aR3331, —(C═S)OR2221, —(C═O)SR2221, —NR2221(C═NR3331)NR222a1R333a1, —NR2221(C═NR3331)OR222a1, —NR2221(C═NR3331)SR333a1, —O(C═O)OR2221, —O(C═O)NR2221R3331, —O(C═O)SR2221, —S(C═O)OR2221, or —S(C═O)NR2221R3331 substituents. 57. The compound or salt of claim 56 wherein R1 is cis- or trans-cyclobutyl substituted at the 3-position by G11 wherein G11 is —OH, —NH2, —N(CH3)2, —NHAc, —NH(CO)NHCH3, —NH(CO)OCH3, —CH2OH, —CH2NH2, —CH2NHAc, CO2H, CONH2, —CH2N(CH3)2, —CH2NH(CO)NHMe, —CH2NH(CO)OCH3, CO2CH3, CONHCH3, 58. The compound or salt of claim 56 wherein R1 is cis- or trans-cyclohexyl substituted at the 4-position by G11 wherein G11 is —OH, —NH2, —N(CH3)2, —NHAc, —NH(CO)NHCH3, —NH(CO)OCH3, —CH2OH, —CH2NH2, —CH2NHAc, CO2H, CONH2, —CH2N(CH3)2, —CH2NH(CO)NHMe, —CH2NH(CO)OCH3, CO2CH3, CONHCH3, 59. A compound selected from the group consisting of: [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine], 1-(3-Benzyloxyphenyl)-3-phenyl-imidazo[1,5-a]pyrazin-8-ylamine, 3-Benzyl-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxyphenyl)-3-naphthalen-1-yl-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxyphenyl)-3-naphthalen-2-yl-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxy-phenyl)-3-cyclopentyl-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxy-phenyl)-3-cyclohexyl-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxy-phenyl)-3-cycloheptyl-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxy-phenyl)-3-(tetrahydro-furan-3-yl)-imidazo[1,5-a]pyrazin-8-ylamine, trans-3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobutanol, 1-(3-Benzyloxy-phenyl)-3-(1-methyl-piperidin-4-yl)-imidazo[1,5-a]pyrazin-8-ylamine, cis-4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid amide, trans-4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid amide, cis-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexyl}-methanol, trans-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexyl}-methanol, cis-2-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-isoindole-1,3-dione, trans-2-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-isoindole-1,3-dione, cis-3-(4-Aminomethyl-cyclohexyl)-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylamine, trans-3-(4-Aminomethyl-cyclohexyl)-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylamine, cis-N-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-acetamide, or trans-N-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-acetamide. or pharmaceutically acceptable salts thereof. 60. A compound selected from the group consisting of: trans-N-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-acetamide, 1-Biphenyl-3-yl-3-cyclobutylimidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Bromo-phenyl)-3-cyclobutylimidazo[1,5-a]pyrazin-8-ylamine, 1-(4′-t-Butylbiphenyl-3-yl)-3-cyclobutylimidazo[1,5-a]pyrazin-8-ylamine, 3-Cyclobutyl-1-(4′-methylbiphenyl-3-yl)-imidazo[1,5-a]pyrazin-8-ylamine, 3-Cyclobutyl-1-(4′-methoxybiphenyl-3-yl)-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxyphenyl)-3-cyclopentylmethylimidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxyphenyl)-3-cyclohexylmethylimidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxyphenyl)-3-trifluoromethylimidazo[1,5-a]pyrazin-8-ylamine, 4-[8-Amino-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]-benzamide, 3-Cyclobutyl-1-phenylimidazo[1,5-a]pyrazin-8-ylamine, (trans-3-(4-Azetidin-1-ylmethyl-cyclohexyl)-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylamine, trans-1-(3-Benzyloxy-phenyl)-3-(4-pyrrolidin-1-ylmethyl-cyclohexyl)-imidazo[1,5-a]pyrazin-8-ylamine), trans-4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid methyl ester, (trans-4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid, (trans-4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid methylamide, 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid ethylamide, trans-1-(3-Benzyloxy-phenyl)-3-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-imidazo[1,5-a]pyrazin-8-ylamine, cis-1-(3-Benzyloxy-phenyl)-3-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-imidazo[1,5-a]pyrazin-8-ylamine, trans-3-(3-Azetidin-1-ylmethylcyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine, cis-3-(3-Azetidin-1-ylmethylcyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine, toluene-4-sulfonic acid 3-[8-amino-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]cyclobutylmethyl ester, {3-[8-Amino-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]cyclobutyl}methanol, 3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutanol, 3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-1-ethyl-cyclobutanol, 1-Allyl-3-[8-amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobutanol, 1-(3-Benzyloxyphenyl)-3-tert-butylimidazo[1,5-a]pyrazin-8-ylamine, cis-1-[3-(Benzyloxy)phenyl]-3-[3-(dimethylamino) cyclobutyl]imidazo[1,5-a]pyrazin-8-amine, 3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenol, 3-Cyclobutyl-1-[3-(4-fluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine, trans-4-[8-Amino-1-(3-hydroxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]cyclohexanecarboxylic acid methyl ester, 3-[8-Amino-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]-benzamide, {3-[8-Amino-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]-phenyl}-methanol, 3-(3-Aminomethylphenyl)-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine, 2-{3-[8-Amino-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]-benzyl}-isoindole-1,3-dione, 4-{8-Amino-1-[3-(2,6-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-3-yl}-cyclohexanecarboxylic acid, cis-3-(3-Dimethylaminomethyl-cyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine, cis-3-(3-Azetidin-1-ylmethylcyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine, cis-3-(3-Pyrrolidin-1-ylmethylcyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine, cis-3-(3-Azidomethyl-cyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine, cis-3-(3-aminomethyl-cyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine, cis-3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobutane-carboxylic acid amide, trans-3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobutane-carboxylic acid amide, 3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-1-hydroxymethyl-cyclobutanol, cis-Toluene-4-sulfonic acid 3-[8-amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-1-hydroxy-cyclobutylmethyl ester, trans-Toluene-4-sulfonic acid 3-[8-amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-1-hydroxy-cyclobutylmethyl ester, trans-3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-1-azetidin-1-ylmethyl-cyclobutanol, cis-3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-1-azetidin-1-ylmethyl-cyclobutanol, 1-[3-(4-tert-Butoxy-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine, 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-benzonitrile, 3-Cyclobutyl-1-[3-(2-nitro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine, 1-[3-(2-Bromo-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine, 1-[3-(3-Aminomethyl-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine, 3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-benzoic acid methyl ester, 3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-benzamide, {3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-methanol, 2-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-benzyl}-isoindole-1,3-dione, 3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-benzoic acid, 3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-N-methyl-benzamide, 1-(3-Benzyloxy-phenyl)-3-(3-methoxymethylene-cyclobutyl)-imidazo[1,5-a]pyrazin-8-ylamine, 3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]cyclobutanecarbaldehyde, cis-1-(3-Benzyloxy-phenyl)-3-(4-methoxy-cyclohexyl)-imidazo[1,5-a]pyrazin-8-ylamine, trans-1-(3-Benzyloxy-phenyl)-3-(4-methoxy-cyclohexyl)-imidazo[1,5-a]pyrazin-8-ylamine, cis-tert-Butyl ({3-[8-amino-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobutyl}oxy)acetate, cis-2-{3-[8-Amino-1-(3-benzyloxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutoxy}ethanol, cis-Toluene-4-sulfonic acid 2-{3-[8-amino-1-(3-benzyloxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutoxy}ethyl ester, cis-1-(3-Benzyloxyphenyl)-3-[3-(2-dimethylaminoethoxy)-cyclobutyl]imidazo[1,5-a]pyrazin-8-yl amine, cis-{3-[8-Amino-1-(3-benzyloxyphenyl)imidazo[1,5-a]pyrazin-3-yl]-cyclobutoxy}acetic acid, cis-2-{3-[8-Amino-1-(3-benzyloxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutoxy}-N-methylacetamide, cis-2-{3-[8-Amino-1-(3-benzyloxy-phenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutoxy}acetamide, 1-(3-benzyloxy-4-methoxyphenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxy-4-fluorophenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxy-4-isopropoxyphenyl)-3-cyclobutylimidazo[1,5-a]pyrazin-8-ylamine, 1-(3-Benzyloxy-4-ethoxyphenyl)-3-cyclobutylimidazo[1,5-a]pyrazin-8-ylamine, 4-(8-Amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)-2-benzyloxyphenol, 4-{8-Amino-1-[3-(2,6-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-3-yl}-cyclohexanecarboxylic acid amide, 4-{8-Amino-1-[3-(2,6-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-3-yl}-cyclohexanecarboxylic acid methylamide, N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-acetamide, or pharmaceutically acceptable salts thereof. 61. A compound selected from the group consisting of: Structure Name N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-benzamide N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-butyramide N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-2-hydroxy-propionamide N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-2-morpholin-4-yl-acetamide N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-2-methoxy-propionamide Tetrahydro-furan-2-carboxylic acid {3-[3-(8-amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-amide Pyrrolidine-2-carboxylic acid {3-[3-(8-amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-amide N-{3-[3-(8-Amino-3-cyc1obutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-methanesulfonamide N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-nicotinamide N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-2-(2-oxo-pyrrolidin-1-yl)-acetamide N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-2-pyridin-4-yl-acetamide N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-2-pyridin-2-yl-acetamide N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-benzenesulfonamide N-{3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-isonicotinamide Pyridine-2-carboxylic acid {3-[3-(8-amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-amide 1-Methyl-1H-imidazole-4-sulfonic acid {3-[3-(8-amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-amide or a pharmaceutically acceptable salt thereof. 62. A compound selected from the group consisting of: Structure Name N-{2-[3-(8-Amino-3-cyclobutyl-imidazol[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-benzamide N-{2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-2-morpholin-4-yl-acetamide N-{2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-2-methoxy-propionamide Tetrahydro-furan-2-carboxylic acid {2-[3-(8-amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-amide N-{2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-2-hydroxy-propionamide N-{2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-nicotinamide N-{2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-2-pyridin-2-yl-acetamide N-{2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-phenyl}-isonicotmamide or a pharmaceutically acceptable salt thereof. 63. A compound selected from the group consisting of: R1 Name 1-(3-Benzyloxy-phenyl)-3-(4-phenylaminomethyl-cyclohexyl)-imidazo[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-(4-morpholin-4-ylmethyl-cyclohexyl)-imidazo[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-cyclohexyl]-imidazo[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-(4-diethylaminomethyl-cyclohexyl)-imidazo[1,5-a]pyrazin-8-ylamine 1-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-piperidin-4-ol 3-(4-Azepan-1-ylmethyl-cyclohexyl)-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-{4-[(ethyl-methyl-amino)-methyl]-cyclohexyl}-imidazo[1,5-a]pyrazin-8-ylamine 1-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-piperidin-3-ol N-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-N,N′,N′-trimethyl-ethane-1,2-diamine 2-({4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-methyl-amino)-ethanol 4-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-piperazin-2-one 1-(3-Benzyloxy-phenyl)-3-[4-(2,5-dihydro-pyrrol-1-ylmethyl)-cyclohexyl]-imidazo[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-(4-propylaminomethyl-cyclohexyl)-imidazo[1,5-a]pyrazin-8-ylamine 3-[4-(Benzylamino-methyl)-cyclohexyl]-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-[4-(isopropylamino-methyl)-cyclohexyl]-imidazo[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-(4-butylaminomethyl-cyclohexyl)-imidazo[1,5-a]pyrazin-8-ylamine N-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-N′,N′-dimethyl-ethane-1,2-diamine 2-({4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-amino)-ethanol (1-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-piperidin-3-yl)-methanol (1-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-piperidin-4-yl)-methanol 1-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-pyrrolidin-3-ol 1-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-pyrrolidin-3-ol 1-(3-Benzyloxy-phenyl)-3-(4-{[(tetrahydro-furan-2-ylmethyl)-amino]-methyl}-cyclohexyl)-imidazo[1,5-a]pyrazin-8-ylamine N-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-N′,N′-dimethyl-propane-1,3-diamine 1-({4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-amino)-propan-2-ol 3-({4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-amino)-propan-1-ol 1-(3-Benzyloxy-phenyl)-3-(4-{[(pyridin-3-ylmethyl)-amino]-methyl}-cyclohexyl)-imidazo[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-{4-[(2-pyrrolidin-1-yl-ethylamino)-methyl]-cyclohexyl}-imidazo[1,5-a]pyrazin-8-ylamine N-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-N′,N′-diethyl-ethane-1,2-diamine 1-(3-Benzyloxy-phenyl)-3-{4-[(1-methyl-piperidin-4-ylamino)-methyl]-cyclohexyl}-imidazo[1,5-a]pyrazin-8-ylamine N-[2-({4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-amino)-ethyl]-acetamide 1-(3-Benzyloxy-phenyl)-3-(4-piperidin-1-ylmethyl-cyclohexyl)-imidazo[I ,5-a]pyrazin-8-ylamine or a pharmaceutically acceptable salt thereof, wherein * is the point of attachment. 64. A compound selected from the group consisting of: R1 Name 1-(3-Benzyloxy-phenyl)-3-(3-phenylaminomethyl-cyclobutyl)-imidazo[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-{3-[(ethyl-methyl-amino)-methyl]-cyclobutyl}-imidazo[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-[3-(2-methyl-pyrrolidin-1-ylmethyl)-cyclobutyl]-imidazo[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-(3-piperidin-1-ylmethyl-cyclobutyl)-imidazo[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-(3-butylaminomethyl-cyclobutyl)-imidazo[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-[3-(2,5-dihydro-pyrrol-1-ylmethyl)-cyclobutyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-(3-Azepan-1-ylmethyl-cyclobutyl)-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-(3-propylaminomethyl-cyclobutyl)-imidazo[1,5-a]pyrazin-8-ylamine 4-{3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobutylmethyl}-piperazin-2-one 3-[3-(Benzylamino-methyl)-cyclobutyl]-1-(3-benzyloxy-phenyl)-imidazol[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-[3-(4-methyl-piperazin-1-ylmethyl)-cyclobutyl]-imidazo[1,5-a]pyrazin-8-ylamine 2-({3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobutylmethyl}-methyl-amino)-ethanol 1-{3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobutylmethyl}-piperidin-4-ol 1-(3-Benzyloxy-phenyl)-3-[3-(isopropylamino-methyl)-cyclobutyl]-imidazo[1,5-a]pyrazin-8-ylamine 1-(3-Benzyloxy-phenyl)-3-(3-morpholin-4-ylmethyl-cyclobutyl)-imidazo[1,5-a]pyrazin-8-ylamine N-[2-({3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobutylmethyl}-amino)-ethyl]-acetamide 1-{3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobutylmethyl}-piperidin-3-ol 2-({3-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclobutylmethyl}-amino)-ethanol 1-(3-Benzyloxy-phenyl)-3-[3-(4-methyl-piperazin-1-ylmethyl)-cyclobutyl]-imidazo[1,5-a]pyrazin-8-ylamine or a pharmaceutically acceptable salt thereof, wherein * is the point of attachment. 65. A compound selected from the group consisting of: R1 Name 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid (2-diethylamino-ethyl)-amide 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid (2-methoxy-ethyl)-amide 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid (2-hydroxy-ethyl)-amide {4-[8-Amino-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexyl}-morpholin-4-yl-methanone 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid benzylamide {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexyl}-(4-hydroxy-piperidin-1-yl)-methanone 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid (2-hydroxy-ethyl)-methyl-amide {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexyl}-azepan-1-yl-methanone {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexyl}-piperidin-1-yl-methanone 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid butylamide 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid (2-acetylamino-ethyl)-amide {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexyl}-(3-hydroxy-piperidin-1-yl)-methanone 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid (2-dimethylamino-ethyl)-methyl-amide 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid ethyl-methyl-amide {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexyl}-pyrrolidin-1-yl-methanone 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid cyclopropylamide 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid phenylamide {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexyl}-(4-methyl-piperazin-1-yl)-methanone 4-{4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarbonyl}-piperazin-2-one {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexyl}-(3-hydroxymethyl-piperidin-1-yl)-methanone {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexyl}-(4-hydroxymethyl-piperidin-1-yl)-methanone {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexyl}-(3-hydroxy-pyrrolidin-1-yl)-methanone {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexyl}-(3-hydroxy-pyrrolidin-1-yl)-methanone 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid (pyridin-2-ylmethyl)-amide 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid (tetrahydro-furan-2-ylmethyl)-amide 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid (3-dimethylamino-propyl)-amide 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid (2-hydroxy-propyl)-amide 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazol[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid (3-hydroxy-propyl)-amide 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid (pyridin-3-ylmethyl)-amide 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid (pyridin-4-ylmethyl)-amide 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide {4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexyl}-azetidin-1-yl-methanone 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazol[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid (1-methyl-piperidin-4-yl)-amide 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid [2-(1H-imidazol-4-yl)-ethyl]-amide 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid propylamide 4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid isobutyl-amide or a pharmaceutically acceptable salt thereof, wherein * is the point of attachment. 66. A compound selected from the group consisting of: R1 Name 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-ethanol 3-Cyclobutyl-1-(3-phenethyloxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-(3-isobutoxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(3-morpholin-4-yl-propoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(2-piperidin-1-yl-ethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-(3-cyclohexylmethoxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(2-imidazol-1-yl-ethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine [3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-acetic acid tert-butyl ester 1-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-butan-2-one [3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-acetic acid methyl ester 3-Cyclobutyl-1-(3-methoxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(3-methyl-but-2-enyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(2-diethylamino-ethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine [3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-acetonitrile 3-Cyclobutyl-1-(3-cyclohexylmethoxy-phenyl)-imidazol[1,5-a]pyrazin-8-ylamine 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-acetamide 3-Cyclobutyl-1-(3-cyclopropylmethoxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-(3-cyclopentylmethoxy-phenyl)-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(2-methoxy-ethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(3-methyl-butoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-1-morpholin-4-yl-ethanone 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-1-pyrrolidin-1-yl-ethanone 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-N-propyl-acetamide 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxy]-N-methyl-acetamide or a pharmaceutically acceptable salt thereof, wherein * is the point of attachment. 67. A compound selected from the group consisting of: R1 Name 3-Cyclobutyl-1-[3-(3-methoxy-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 1-[3-(2-Chloro-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine 1-[3-(3-Chloro-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine 1-[3-(4-Chloro-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(pyridin-3-ylmethoxy)-phenyl]-imidazol[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(5-methyl-isoxazol-3-ylmethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(2,6-dichloro-pyridin-4-ylmethoxy)-phenyl]-imidazol[1,5-a]pyrazin-8-ylamine 1-[3-(Biphenyl-4-ylmethoxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine 1-[3-(2-Benzenesulfonyl-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(naphthalen-2-ylmethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(4-[1,2,4]triazol-1-yl-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(4-methyl-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(2,6-dichloro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(3-trifluoromethyl-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 1-[3-(4-tert-Butyl-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine 1-[3-(Biphenyl-2-ylmethoxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine 4-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-benzonitrile 3-Cyclobutyl-1-[3-(2,3-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(3,5-dimethyl-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(3-trifluoromethoxy-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 2-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-benzonitrile 3-Cyclobutyl-1-[3-(4-trifluoromethoxy-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(3,4-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 1-[3-(Benzo[1,2,5]oxadiazol-5-ylmethoxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(3,4,5-trifluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(2-fluoro-5-trifluoromethyl-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(4-difluoromethoxy-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 1-[3-(5-Chloro-benzo[b]thiophen-3-ylmethoxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine 1-[3-(4-Chloro-2-fluoro-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(3,5-difluoro-benzyloxy)-phenyl]-imidazol[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(2,6-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(3-fluoro-benzyloxy)-phenyl]-imidazol[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(naphthalen-1-ylmethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(2,5-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 1-[3-(2-Chloro-6-fluoro-benzyloxy)-phenyl]-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(2,3,6-trifluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(2-fluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(2-difluoromethoxy-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(3-difluoromethoxy-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(quinolin-8-ylmethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(1-phenyl-ethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-[3-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-phenoxymethyl]-benzoic acid 3-Cyclobutyl-1-[3-(pyridin-2-ylmethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(3,5-dimethyl-isoxazol-4-ylmethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine 3-Cyclobutyl-1-[3-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine or a pharmaceutically acceptable salt thereof, wherein * is the point of attachment. 68. A compound selected from the group consisting of: R1 Name [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-isopropyl-amine [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-ethyl-amine Allyl-[1-(3-benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-amine [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-prop-2-ynyl-amine [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-propyl-amine [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-cyclopropylmethyl-amine Benzyl-[1-(3-benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-amine [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-phenyl-amine [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-methyl-amine [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-(2-methoxy-ethyl)-amine 1-(3-Benzyloxy-phenyl)-3-cyclobutyl-8-morpholin-4-yl-imidazo[1,5-a]pyrazine [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-diethyl-amine [1-(3-Benzyloxy-phenyl)-3-cyclobutyl-imidazo[1,5-a]pyrazin-8-yl]-(2-methoxy-ethyl)-amine or a pharmaceutically acceptable salt thereof, wherein * is the point of attachment.