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|Title:||Vaginal pharmaceutical compositions and methods for preparing them|
|Abstract:||Vaginal pharmaceutical compositions are described. These compositions contain (i) an active pharmaceutical ingredient selected from the group consisting of antimicrobial imidazoles and mixtures thereof, and (ii) a polysaccharide, wherein the pH of the composition is greater than 4.25 and less than about 8. In particularly preferred compositions, the active pharmaceutical ingredient includes metronidazole and the polysaccharide includes hypromellose. These compositions can be applied to vaginal tissue for treatment of various diseases, such as bacterial vaginosis, or for prophylaxis.|
|Inventor(s):||Bentley; Christine Lynn (Caledonia, MI), Feldtmose; Karen (Pennsburg, PA)|
|Assignee:||Teva Pharmaceuticals USA, Inc. (PA)|
1. A viscous vaginal pharmaceutical composition comprising an aqueous gel consisting essentially of: about 0.75% metronidazole; about 3.5% hypromellose; about 3% propylene
glycol; about 0.05% edetate disodium; and about 0.08% methylparaben; about 0.02% propylparaben; and about 93% water, wherein the pH of the composition is from about 5 to about 6.5.
2. A vaginal insert comprising the composition of claim 1 housed in a medical device having a means for controlling the dose of the active pharmaceutical ingredient to a patient.
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