Generated: May 27, 2017
|Title:||Vaginal pharmaceutical compositions and methods for preparing them|
|Abstract:||Vaginal pharmaceutical compositions are described. These compositions contain (i) an active pharmaceutical ingredient selected from the group consisting of antimicrobial imidazoles and mixtures thereof, and (ii) a polysaccharide, wherein the pH of the composition is greater than 4.25 and less than about 8. In particularly preferred compositions, the active pharmaceutical ingredient includes metronidazole and the polysaccharide includes hypromellose. These compositions can be applied to vaginal tissue for treatment of various diseases, such as bacterial vaginosis, or for prophylaxis.|
|Inventor(s):||Bentley; Christine Lynn (Caledonia, MI), Feldtmose; Karen (Pennsburg, PA)|
|Assignee:||Teva Pharmaceuticals USA, Inc. (PA)|
1. A viscous vaginal pharmaceutical composition comprising an aqueous gel consisting essentially of: about 0.75% metronidazole; about 3.5% hypromellose; about 3% propylene
glycol; about 0.05% edetate disodium; and about 0.08% methylparaben; about 0.02% propylparaben; and about 93% water, wherein the pH of the composition is from about 5 to about 6.5.
2. A vaginal insert comprising the composition of claim 1 housed in a medical device having a means for controlling the dose of the active pharmaceutical ingredient to a patient.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.