.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 7,456,160

« Back to Dashboard

Claims for Patent: 7,456,160

Title:Formulation
Abstract:The invention relates to a novel sustained release pharmaceutical formulation adapted for administration by injection containing the compound 7.alpha.-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1- ,3,5(10)-triene-3,17.beta.-diol, more particularly to a formulation adapted for administration by injection containing the compound 7.alpha.-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-- triene-3,17.beta.-diol in solution in a ricinoleate vehicle which additionally comprises at least one alcohol and a non-aqueous ester solvent which is miscible in the ricinoleate vehicle.
Inventor(s): Evans; John R (Macclesfield, GB), Grundy; Rosalind U (Macclesfield, GB)
Assignee: AstraZeneca AB (Sodertalje, SE)
Application Number:10/872,784
Patent Claims: 1. A method of treating a hormonal dependent benign or malignant disease of the breast or reproductive tract by administration to a human in need of such treatment an intra-muscular injection of a pharmaceutical formulation comprising fulvestrant, a mixture of from 10 to 30% weight of ethanol and benzyl alcohol per volume of formulation and 10 to 25% weight of benzyl benzoate per volume of formulation and a sufficient amount of a castor oil vehicle, whereby a therapeutically significant blood plasma fulvestrant concentration of at least 2.5 ngml.sup.-1 is attained for at least 2 weeks after injection.

2. A method of treating a hormonal dependent benign or malignant disease of the breast or reproductive tract by administration to a human in need of such treatment an intra-muscular injection of a pharmaceutical formulation comprising fulvestrant, a mixture of from 10 to 30% weight of a mixture of ethanol and benzyl alcohol per volume of formulation and from 10 to 25% weight of benzyl benzoate per volume of formulation and a sufficient amount of a castor oil vehicle, whereby the formulation comprises at least 45 mgml.sup.-1 of fulvestrant.

3. The method as claimed in claim 1 or 2 wherein the formulation comprises a mixture of from 15 to 25% weight of a mixture of ethanol and benzyl alcohol per volume of formulation and from 12 to 20% weight of benzyl benzoate per volume of formulation.

4. The method as claimed in claim 1 or 2 wherein the formulation comprises a mixture of from 8.5 to 11.5% weight of ethanol per volume of formulation and from 8.5 to 11.5% weight of benzyl alcohos per volume of formulation an 12 to18% weight of benzyl benzoate per volume of formulation.

5. The method as claimed in claim 1 wherein the blood plasma fulvestrant concentration is attained for at least 3 weeks after injection.

6. The method as claimed in claim 1 wherein the blood plasma fulvestrant concentration is attained for at least 4 weeks after injection.

7. The method as claimed in claim 1 wherein a therapeutically significant blood plasma fulvestrant concentration of at least 3 ngml.sup.-1 is attained for at least 2 weeks after injection.

8. The method as claimed in claim 1 wherein a therapeutically significant blood plasma fulvestrant concentration of at least 8.5 ngml.sup.-1 is attained for at least 2 weeks after injection.

9. The method as claimed in claim 1 wherein a therapeutically significant blood plasma fulvestrant concentration of at least 8.5 ngml.sup.-1 is attained for at least 4 weeks after injection.

10. The method as claimed in claim 1 or 2 wherein the total volume of the formulation administered to said human is 6m1 or less, and the concentration of fulvestrant in said formulation is at least 45 mgml.sup.-1.

11. The method as claimed in claim 1 or 2 wherein the total volume of the formulation administered to said human is 6 ml or less, and the total amount of fulvestrant in said volume of formulation is 250 mg or more.

12. The method as claimed in claim 1 or 2 wherein the benign or malignant disease is breast cancer.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc