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Last Updated: December 19, 2025

Claims for Patent: 7,452,882

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Summary for Patent: 7,452,882

Title:	Thyroid hormone analogs
Abstract:	Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
Inventor(s):	Nancy-Ellen Haynes, Denis J. Kertesz, Sherrie Lynn Pietranico-Cole, Yimin Qian, Nathan Robert Scott, Sung-Sau So, Kshitij Chhabilbhai Thakkar, Jefferson Wright Tilley
Assignee:	Hoffmann La Roche Inc
Application Number:	US11/488,870
Patent Claims:	1. A compound of the formula (I): wherein: A is O, CH2, S, SO or SO2; X and Y are each independently selected from the group consisting of Br, Cl and —CH3; R1 is Z is H, or —C≡N; R2 is lower alkyl; and R3 is H or lower alkyl; or a pharmaceutically acceptable salt thereof. 2. The compound according to claim 1, wherein X and Y are each Br. 3. The compound according to claim 1, wherein X and Y are each Cl. 4. The compound according to claim 1, wherein X and Y are each —CH3. 5. The compound according to claim 1, wherein X is Cl, and Y is —CH3. 6. The compound according to claim 1, wherein R2 is lower alkyl having from 1 to 3 C atoms. 7. The compound according to claim 1, wherein R2 is lower alkyl having 3 C atoms. 8. The compound according to claim 1, wherein R3 is CH3. 9. The compound according to claim 1, which is or a pharmaceutically acceptable salt thereof. 10. The compound according to claim 3, which is or a pharmaceutically acceptable salt thereof. 11. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

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