Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Delivery of multiple doses of medications|
|Abstract:||Dosage forms for oral administration of a methylphenidate drug are provided. The dosage forms provide a substantially immediate dose of methylphenidate upon ingestion, followed by one or more additional doses at predetermined times. By providing such a drug release profile, the dosage forms eliminate the need for a patient to carry an additional dose for ingestion during the day. The dosage forms and methods provided are useful in administering methylphenidate and pharmaceutically acceptable salts thereof, which generally require one or more doses throughout the day.|
|Inventor(s):||Mehta; Atul M. (Ramsey, NJ), Zeitlin; Andrew L. (Millington, NJ), Dariani; Maghsoud M. (Fanwood, NJ)|
|Assignee:||Celgene Corporation (Warren, NJ)|
1. A solid dosage form comprising d-threo methylphenidate or salt thereof providing a plasma concentration profile of said d-threo methylphenidate or salt thereof comprising two
maxima temporally separated by from about two hours to about seven hours, said solid dosage form comprising: (a) a first group of particles comprising from about 2% to about 99% by weight of d-threo methylphenidate or salt thereof; and (b) a second
group of particles comprising coated particles, said coated particles comprising from about 2% to about 75% by weight of d-threo methylphenidate or salt thereof in admixture with one or more binders and a coating comprising an ammonio methacrylate
2. The solid dosage form of claim 1, wherein said solid dosage form is a tablet.
3. The solid dosage form of claim 1, wherein said solid dosage form is a capsule.
4. The solid dosage form of claim 1, wherein the d-threo methylphenidate or salt thereof is d-threo methylphenidate hydrochloride.
5. The solid dosage form of claim 1, wherein the first group of particles provides a substantially immediate dose of said d-threo methylphenidate upon ingestion by a mammal.
6. The solid dosage form of claim 1, wherein the magnitude of said plasma concentration profile maxima differ by no more than about 30%.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.