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Generated: January 20, 2018

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Claims for Patent: 7,429,602

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Summary for Patent: 7,429,602
Title:Treating conjunctivitis by topically administering an epinastine solution to the conjunctiva
Abstract:Treating allergic conjunctivitis by administered aqueous solutions containing epinastine, optionally in the form of its racemate or its enantiomers and optionally, in the form of the pharmacologically acceptable acid addition salts thereof, to the conjunctiva.
Inventor(s): Trach; Volker (Biberach, DE), Duschler; Gerold (Ehingen, DE)
Assignee: Boehringer Ingelheim Pharma GmbH & Co. Kg (Ingelheim, DE)
Application Number:11/863,008
Patent Claims: 1. A method for treating allergic conjunctivitis, comprising topically administering to the conjunctiva of a host in need of such treatment a solution comprising: (a) a pharmaceutically active ingredient consisting essentially of epinastine, optionally in the form of its racemate, or an enantiomer thereof, or a pharmacologically acceptable acid addition salt thereof, in a concentration of 0.005 to 0.5 mg/ml of solution; (b) water or physiologically acceptable saline; and (c) a preservative, optionally also including one or more chelating agents, viscosity agents, penetration promoters, antioxidants, substances to adjust the tonicity of the solution, or a physiologically acceptable buffer.

2. A method for inhibiting the influx of neutrophils and eosinophils into the tissue of the ocular conjunctiva of a host to reduce the occurrence of late phase allergic reactions, comprising: topically administering to the ocular conjunctiva of the host a solution comprising: (a) a pharmaceutically active ingredient consisting essentially of epinastine, optionally in the form of its racemate, an enantiomer thereof, or a pharmacologically acceptable acid addition salt thereof, in a concentration of 0.005 to 0.5 mg/ml of solution; (b) water or physiologically acceptable saline; and (c) a preservative, optionally also including one or more chelating agents, viscosity agents, penetration promoters, antioxidants, substances to adjust the tonicity of the solution or a physiologically acceptable buffer.

3. The method of claim 1, wherein the solution comprises: (a) a pharmaceutically active ingredient consisting essentially of epinastine hydrochloride, in a concentration of about 0.5 mg/ml of solution; (b) water or physiologically acceptable saline; (c) benzalkonium chloride as a preservative; and (d) a buffer to adjust the pH within the range of 6.5 to 7.2.

4. The method of claim 2, wherein the solution comprises: (a) a pharmaceutically active ingredient consisting essentially of epinastine hydrochloride, in a concentration of about 0.5 mg/ml of solution; (b) water or physiologically acceptable saline; (c) benzalkonium chloride as a preservative; and (d) a buffer to adjust the pH within the range of 6.5 to 7.2.

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Serving leading biopharmaceutical companies globally:

Express Scripts
Citi
Chubb
Queensland Health
Johnson and Johnson
Merck
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Cerilliant

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