Find generic entry opportunities
Drug patents …
… from Kazakhstan to Kalamazoo
Anticipate generic drug launch
Deep knowledge on
small-molecule drugs and
the 110,000 global patents
Manage your formulary budget
Proactively manage your pharmacy inventory
|Title:||Compounds and methods for delivery of prostacyclin analogs|
|Abstract:||This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula: ##STR00001##|
|Inventor(s):||Phares; Ken (Chapel Hill, NC), Mottola; David (Cary, NC)|
|Assignee:||United Therapeutics Corporation (Silver Spring, MD)|
1. A compound having the following structure: ##STR00032##
2. The compound of claim 1, wherein the compound melts at about 107.degree. C.
3. The compound of claim 1, wherein the compound has an x-ray powder diffraction pattern having a pattern peak at about 17.2 degrees 2 theta.