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|Title:||Solid dispersion pharamaceutical formulations|
|Abstract:||A pharmaceutical composition is disclosed which comprises a solid dispersion of an HIV protease inhibitor in a water soluble carrier, such as PEG, having enhanced bioavailability and improved dissolution properties. The solid dispersion may optionally be encapsulated in hard gelatin capsules, compressed into a tablet, or may be granulated with a pharmaceutically acceptable granulating agent. Also disclosed are methods of making said solid dispersion and methods of treating an HIV infection employing said solid dispersion.|
|Inventor(s):||Fort; James J. (Midlothian, VA), Krill; Steven L. (Chatham, NJ), Law; Devalina (Libertyville, IL), Qiu; Yihong (Gurnee, IL), Porter; William R. (Vernon Hills, IL), Schmitt; Eric A. (Libertyville, IL)|
|Assignee:||Abbott Laboratories (Abbott Park, IL)|
1. A pharmaceutical composition comprising ritonavir, wherein ritonavir in said composition is formulated as a solid dispersion of amorphous ritonavir in a matrix including a
water soluble polymer.
2. A pharmaceutical composition of claim 1, comprising a gelatin capsule which encapsulates said solid dispersion.
3. A pharmaceutical composition of claim 1 which is a tablet comprising said solid dispersion.
4. The pharmaceutical composition of claim 1, wherein said water soluble polymer is PEG.
5. The pharmaceutical composition of claim 1, wherein said water soluble polymer is PEG 8000.
6. The pharmaceutical composition of claim 1, wherein said solid dispersion further comprises (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-[2S-(1-tetrahyd- ro-pyrimid-2-onyl)-3-methylbutanoyl]amino-1,6-diphenylhexane (ABT-378).
7. The pharmaceutical composition of claim 1, further comprising a pharmaceutically-acceptable filler, diluent, lubricant or disintegrant.
8. The pharmaceutical composition of claim 1, wherein said solid dispersion is ground and formulated into a delivery system.
9. A method of treating an HIV infection comprising administering a pharmaceutical composition of claim 1 to a mammal in need of such treatment.
10. A method of treating an HIV infection comprising administering the pharmaceutical composition of claim 6 to a mammal in need of such treatment.
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