Claims for Patent: 7,339,053

Summary for Patent: 7,339,053

Title:	4′-C-substituted-2-haloadenosine derivative
Abstract:	The present invention provides a 4′-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]: (wherein X represents a halogen atom, R1 represents an ethynyl group or a cyano group, and R2 represents hydrogen, a phosphate residue, or a phosphate derivative residue). The present invention also provides a pharmaceutical composition containing the derivative and a pharmaceutically acceptable carrier therefor. Such derivative is useful as medicine for the treatment of Acquired Immune Deficiency Syndrome (AIDS).
Inventor(s):	Satoru Kohgo, Hiroshi Ohrui, Eiichi Kodama, Masao Matsuoka, Hiroaki Mitsuya
Assignee:	Yamasa Corp
Application Number:	US11/087,588
Patent Claims:	1. A 4′-C-substituted-2-haloadenosine derivative, which is 2′-deoxy-4′-C-ethynyl-2-fluoroadenosine. 2. A 4′-C-substituted-2-haloadenosine derivative, which is 4′-C-cyano-2′-deoxy-2-fluoroadenosine. 3. A 4′-C-substituted-2-haloadenosine derivative, which is 2-chloro-2′-deoxy-4′-C-ethynyladenosine. 4. A 4′-C-substituted-2-haloadenosine derivative, which is 2′-deoxy-4′-C-ethynyl-2-fluoroadenosine 5′-H-phosphonate. 5. A 4′-C-substituted-2-haloadenosine derivative, which is 2′,3′-didehydro-2′,3′-dideoxy-4′-C-ethynyl-2-fluoroadenosine. 6. A 4′-C-substituted-2-haloadenosine derivative, which is 2′,3′-didehydro-2 ′,3′-dideoxy-4′-C-cyano-2-fluoroadenosine. 7. A 4′-C-substituted-2-haloadenosine derivative, which is 2′,3′-didehydro-2′,3′-dideoxy-4′-C-ethynyl-2-chloroadenosine. 8. A 4′-C-substituted-2-haloadenosine derivative, which is 2′,3′-dideoxy-4′-C-ethynyl-2-fluoroadenosine. 9. A 4′-C-substituted-2-haloadenosine derivative, which is 2′,3′-dideoxy-4′-C-cyano-2-fluoroadenosine. 10. A 4′-C-substituted-2-haloadenosine derivative, which is 2′,3′-dideoxy-4′-C-ethynyl-2-chloroadenosine.